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View Structure Prediction Details

Protein: Ih-PB
Organism: Drosophila melanogaster
Length: 1290 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Ih-PB.

Description E-value Query
Range
Subject
Range
gi|62288206 - gi|62288206|gb|AAX78393.1| hyperpolarization-activated ion channel variant DMIH-A1B1C1 [Drosophila m...
963.0 [0..1] [1290..1]

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Predicted Domain #1
Region A:
Residues: [1-135]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHVKHTQRRV SGPGAFGTFT NDQRASRDNL CPDNQQQQQQ RHSHSHQHLV RQSLVSLSNG  60
   61 QPAASAAPDS VSLLRAGDDQ QQHPQQPHLQ QQQQQQQHLQ QQQQRHRSSS SRLSTSGISK 120
  121 QNSSDSRSGL RILDS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [136-331]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SHSPVSCGTQ SVSSTGGQSA LYDACHEYSR SLSAAAAEGA ASLLKSHYSD QQLAQTEPDP  60
   61 EPDPERDRDR DRDRDRDRER ERRHLTNLNL NLSSEYDYSG SDKQQLVNET YIFKCIANSP 120
  121 SFLRTNKIKE QSKKLRNLSL KTRTAKKKGQ IISKSNAVSD NSLHPGDKYL NLYLVEKKHS 180
  181 LQPQVASTSS SINTTH

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [332-428]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PQASSAPASS SSTCTKAPQL PALSAVAARQ QQLLLNGSLK GKGQSQSQGQ SRQTLPGHRA  60
   61 SVRSESGSGS SHTIPATGKS PPVPHSLAAK ISSSASG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [429-602]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKNCNLLSAS SNSCHKLNAH AQGSGAGSGS GSGSGSGPPG HSHYAAASPK SSVSSNGHLN  60
   61 KYCLTDLTRR KAEFNRQLSA PTDYTHHSSS NGSQQEGSSE ANEGHEPVGE STITVASAGV 120
  121 SYPHPYSYPY HYAHHASSAT APANLKASLQ LHSFGSHHPC PYPARPTSTS CTNS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [603-713]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FNRRHIRRHK GKLGDRLLSG DSEESVRCSY CSVLNVNDND LRISFENTCT DSLVTAFDDE  60
   61 ALLICDQGTE MVHFDDVSLY GTPKEEPMPN IPIVSEKVSA NFLKSQLQSW F

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [714-750]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QPTDNRLAMK LFGSRKALVK ERIRQKTSGH WVIHPCS

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 33.823909
Match: PF08412.1
Description: No description for PF08412.1 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [751-1090]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SFRFYWDLCM LLLLVANLII LPVAISFFND DLSTRWIAFN CLSDTIFLID IVVNFRTGIM  60
   61 QQDNAEQVIL DPKLIAKHYL RTWFFLDLIS SIPLDYIFLI FNQDFSDSFQ ILHAGRALRI 120
  121 LRLAKLLSLV RLLRLSRLVR YVSQWEEVYF LNMASVFMRI FNLICMMLLI GHWSGCLQFL 180
  181 VPMLQGFPSN SWVSINELQE SYWLEQYSWA LFKAMSHMLC IGYGRFPPQS LTDMWLTMLS 240
  241 MISGATCYAL FLGHATNLIQ SLDSSRRQYR EKVKQVEEYM AYRKLPRDMR QRITEYFEHR 300
  301 YQGKFFDEEL ILGELSEKLR EDVINYNCRS LVASVPFFAN 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 17.69897
Match: 2a79B
Description: Mammalian Shaker Kv1.2 potassium channel- beta subunit complex
Matching Structure (courtesy of the PDB):

Predicted Domain #8
Region A:
Residues: [1091-1290]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ADSNFVSDVV TKLKYEVFQP GDIIIKEGTI GTKMYFIQEG VVDIVMANGE VATSLSDGSY  60
   61 FGEICLLTNA RRVASVRAET YCNLFSLSVD HFNCVLDQYP LMRKTMETVA AERLNKIGKN 120
  121 PNIMHQKDEQ LSNPESNTIT AVVNALAAEA DDCKDDDMDL KENLLHGSES SIAEPVQTIR 180
  181 EGLPRPRSGE FRALFEGNTP 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 37.221849
Match: 1q3eA
Description: HCN2J 443-645 in the presence of cGMP
Matching Structure (courtesy of the PDB):

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