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Protein Overview: acr-21

General Information:
Name(s) found: acr-21 / CE39358 [WormBase]
Description(s) found:
Found 13 descriptions.
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  • WBGene00000060 locus:acr-21 status:Predicted UniProt:Q9N5U8 protein_id:CCD63921.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 469 amino acids

    Gene Ontology:
    Cellular Component: postsynaptic membrane [IEALink to PubMed article]
    membrane [IEALink to PubMed article]
    integral to membrane [IEALink to PubMed article]
    Biological Process: ion transport [IEALink to PubMed article]
    transport [IEALink to PubMed article]
    Molecular Function: neurotransmitter receptor activity [IEALink to PubMed article]
    extracellular ligand-gated ion channel activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRLYRDLLYD YNNEVRPSVH SKEPINVTFV FSLTQIIDVD ERNQILTTNS WIRLHWVDYK  60
   61 LVWDPRLYQN VTRIHIPSDK IWKPDIILYN NADAQYMKSV MSTDVIVDYL GNIHWPLSAI 120
  121 FTSSCPLDVK HYPFDRQTCI LKYASWAYDG TKIDLLLKSE QGDLTNYITN TEWSLIGIRA 180
  181 EKNQVIYSCC PEPYPFIDVH VTIERRAMFY VFNLILPCVL ISLIALMGFY MPTDSGEKVT 240
  241 LGITSLLSTT VFLMMVAEGM PPTAEALPLI GIYFGVTIML VALGTAMTVF TVNIHHTGVH 300
  301 GYPVPPFLQI FAFRYLSKIL FVRIEPYHSI AHHVRYMYQK EHPTECTLSA SVHYKRLHDF 360
  361 DANVAKKEEQ YGLQRDMSNL SVISANVHCN PDDRLLLGSQ SSQKNLNKFD SEKNLRSSLS 420
  421 IRSGSPTAKK KVGSIVTITL NYCLYILTFK ITGSRSCIEY CPKYKNNGD

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..317] PSI-BLAST 76.69897 Refined structure of the nicotinic acetylcholine receptor at 4A resolution.
    2 View Details [318..469] PSI-BLAST 41.0 Acetylcholine receptor protein, delta chain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • acetylcholine binding
    		•  13.9752632471881 bayes_pls_golite062009
  • acetylcholine receptor activity
    		•  13.7533645836795 bayes_pls_golite062009
  • nicotinic acetylcholine-activated cation-selective channel activity
    		•  13.1511875247796 bayes_pls_golite062009
  • extracellular ligand-gated ion channel activity
    		•  11.7813202122163 bayes_pls_golite062009
  • excitatory extracellular ligand-gated ion channel activity
    		•  11.7813202122163 bayes_pls_golite062009
  • cation channel activity
    		•  11.1823056937132 bayes_pls_golite062009
  • ion channel activity
    		•  11.1753684044644 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  11.0903806681397 bayes_pls_golite062009
  • channel activity
    		•  11.0903806681397 bayes_pls_golite062009
  • gated channel activity
    		•  11.0397691626728 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  10.9870635461822 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  10.9375522860542 bayes_pls_golite062009
  • ligand-gated ion channel activity
    		•  9.34902726749692 bayes_pls_golite062009
  • ligand-gated channel activity
    		•  9.34902726749692 bayes_pls_golite062009
  • amine binding
    		•  9.11982124959723 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  7.22265353460749 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  6.7875346065164 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  6.75385972663331 bayes_pls_golite062009
  • chloride channel regulator activity
    		•  6.26397218402661 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  5.4080353535498 bayes_pls_golite062009
  • receptor activity
    		•  5.11329651194787 bayes_pls_golite062009
  • transporter activity
    		•  5.11262082564788 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  5.03439798256257 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  4.91314874981447 bayes_pls_golite062009
  • neurotransmitter binding
    		•  4.25797760547212 bayes_pls_golite062009
  • neurotransmitter receptor activity
    		•  4.15404686068319 bayes_pls_golite062009
  • molecular transducer activity
    		•  4.12549692767753 bayes_pls_golite062009
  • signal transducer activity
    		•  4.12549692767753 bayes_pls_golite062009
  • binding
    		•  2.4916526322278 bayes_pls_golite062009
  • beta-amyloid binding
    		•  1.6057916207188 bayes_pls_golite062009
  • G-protein coupled receptor activity
    		•  1.42422063123689 bayes_pls_golite062009
  • serotonin binding
    		•  1.33584589886834 bayes_pls_golite062009
  • serotonin-activated cation-selective channel activity
    		•  1.31324203158511 bayes_pls_golite062009
    		• 1.15330735898282 bayes_pls_golite062009
  • channel regulator activity
    		•  1.13923307634251 bayes_pls_golite062009
  • toxin binding
    		•  0.79651014283675 bayes_pls_golite062009
  • drug binding
    		•  0.64715018605883 bayes_pls_golite062009
  • protein binding
    		•  0.406954670483187 bayes_pls_golite062009
  • kinase binding
    		•  0.365355763029699 bayes_pls_golite062009
  • protein kinase binding
    		•  0.350601457777817 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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