Protein Overview: TRF5

General Information:
Name(s) found:	TRF5 / YNL299W [SGD]
Description(s) found: Found 17 descriptions. SHOW ALL	Non-canonical poly(A) polymerase, involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Pap2p [SGD]
Organism:	Saccharomyces cerevisiae
Length:	642 amino acids
Gene Ontology:
Cellular Component:	nucleus [ISS] nucleolus [IDA]
Biological Process:	ncRNA polyadenylation [IGI] mitotic sister chromatid cohesion [IGI] rRNA catabolic process [IGI][IMP] snRNA catabolic process [IGI] snoRNA catabolic process [IGI] ncRNA polyadenylation involved in polyadenylation-dependent ncRNA catabolic process [IGI]
Molecular Function:	DNA-directed DNA polymerase activity [IDA][ISS] polynucleotide adenylyltransferase activity [IDA ][IGI ][IMP ][ISS ]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTRLKAKYSP TKGKRKEDKH TKRMRKSSFT RTQKMLEVFN DNRSHFNKYE SLAIDVEDDD  60
   61 TFGNLVLMEN DKSDVDIPVI EEVTSSEDEQ RAESSKRNNS LEDNQDFIAF SDSSEDETEQ 120
  121 IKEDDDERSS FLLTDEHEVS KLTSQQSLNT ESACNVEYPW IRNHCHSKQR RIADWLTSEI 180
  181 KDFVHYISPS KNEIKCRNRT IDKLRRAVKE LWSDADLHVF GSFATDLYLP GSDIDCVVNS 240
  241 RNRDKEDRNY IYELARHLKN KGLAIRMEVI VKTRVPIIKF IEPQSQLHID VSFERTNGLE 300
  301 AAKLIREWLR DSPGLRELVL IIKQFLHSRR LNNVHTGGLG GFTVICLVYS FLNMHPRIKS 360
  361 NDIDVLDNLG VLLIDFFELY GKNFGYDDVA ISISDGYASY IPKSCWRTLE PSRSKFSLAI 420
  421 QDPGDPNNNI SRGSFNMKDI KKAFAGAFEL LVNKCWELNS ATFKDRVGKS ILGNVIKYRG 480
  481 QKRDFNDERD LVQNKAIIEN ERYHKRRTRI VQEDLFINDT EDLPVEEIYK LDEPAKKKQK 540
  541 AKKDKREGEI KKSAIPSPPP DFGVSRSKLK RKVKKTDQGS LLHQNNLSID DLMGLSENDQ 600
  601 ESDQDQKGRD TPSGQDEKSP LETKTVDAQT RRDYWLSKGQ AL

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Krogan NJ, et al. (2006)		AIR1 AIR2 MTR4 PAP2 PSO2 RPL18A, RPL18B STE4 TRF5
View Details	Qiu et al. (2008)		AIR1 NSR1 TGS1 TRF5

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	MLP2	#34 Asynchronous SPB prep	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

	PROTEIN(S)	PUBLICATION
View Data	TRF5	Huh WK, et al. (2003)
View Data	TRF5 and NOP56	Huh WK, et al. (2003)

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.51

Protein Overview: TRF5

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: