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Protein Overview: iff-1

General Information:
Name(s) found: iff-1 / CE37787 [WormBase]
Description(s) found:
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  • WBGene00002064 locus:iff-1 Eukaryotic translation initiation factor 5A-1 status:Confirmed UniProt:P34563 protein_id:CAA81597.2 [WormBase]
  • gi|71990399|ref|NP_499152.2| Initiation Factor Five (eIF-5A) homologs family member (iff-1) [Caenorhabditis elegans] [NCBI NR]
  • gi|55785391|emb|CAA81597.2| C. elegans protein T05G5.10, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • CE37787 WBGene00002064 locus:iff-1 Initiation factor 5A status:Partially_confirmed [wormpep150.fasta]
  • 37787 WBGene00002064 locus:iff-1 Initiation factor 5A status:Partially_confirmed [wormpep150-phg-orf-ecoli-rand.fasta]
  • CE37787 WBGene00002064 locus:iff-1 Initiation factor 5A status:Partially_confirmed SW:P34563 protein_id:CAA81597.2 [WormBase_C-elegans_na_01-20-2005_combined_reversed.fasta]
  • CE37787 WBGene00002064 locus:iff-1 Initiation factor 5A status:Confirmed UniProt:P34563 protein_id:CAA81597.2 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE37787 WBGene00002064 locus:iff-1 Initiation factor 5A status:Confirmed UniProt:P34563 protein_id:CAA81597.2| [wormORF-contam.fasta]
  • Initiation Factor Five (eIF-5A) homologs family member (iff-1) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Hypothetical protein T05G5.10 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • CE37787 WBGene00002064 locus:iff-1 Initiation factor 5A status:Confirmed [WormBase_C-elegans_wp180_08-19-2007_reversed.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE37787 WBGene00002064 locus:iff-1 status:Confirmed UniProt:P34563 protein_id:CAA81597.2 Eukaryotic translation initiation factor 5A-1 [wormpep246-ecoli-contam.fasta]
    • Organism: Caenorhabditis elegans
    Length: 195 amino acids

    Gene Ontology:
    Cellular Component: cytosol [ISS]
    Biological Process: embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed article]
    gamete generation [IMPLink to PubMed article]
    translational initiation [IEALink to PubMed article][ISS]
    reproduction [IMPLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed article]
    Molecular Function: translation initiation factor activity [IEALink to PubMed article][ISS]
    translation regulator activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRLPTKLNRV SKKNRNLGFG GWMARVAAPK TIESMSEDHH DEEQFDSAES GAAATFPKQC  60
   61 SALRKNEHVM IRGRPCKIVE MSTSKTGKHG HAKVHMVAID IFTTKKLEDI CPSTHNMDVP 120
  121 VVKRREYILM SIEDGFCSLM DPESCELKDD LKMPEGDLGN TIREALEKDE GSVLVQVVAA 180
  181 CGEEAILGYK ISTKE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..195] PSI-BLAST 32.30103 Structural Analysis of Leishmania mexicana eukaryotic initiation factor 5a

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • U6 snRNA binding
    		•  7.69488393698619 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  6.60650180781768 bayes_pls_golite062009
  • structural molecule activity
    		•  6.0174879876147 bayes_pls_golite062009
  • translation initiation factor activity
    		•  5.09596850944863 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.89165617439497 bayes_pls_golite062009
  • translation elongation factor activity
    		•  3.58178742491041 bayes_pls_golite062009
  • DNA binding
    		•  3.38561002225202 bayes_pls_golite062009
  • binding
    		•  2.83465364476231 bayes_pls_golite062009
  • RNA binding
    		•  1.76502371106766 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.74890841494748 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.69669059514663 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.54386990150255 bayes_pls_golite062009
  • translation regulator activity
    		•  1.46320772716954 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  1.40718318783582 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  1.38349489974693 bayes_pls_golite062009
  • protein binding
    		•  1.20309946451799 bayes_pls_golite062009
  • transcription activator activity
    		•  0.990244702925461 bayes_pls_golite062009
  • mRNA binding
    		•  0.883475899526061 bayes_pls_golite062009
  • transcription factor activity
    		•  0.859071050218437 bayes_pls_golite062009
  • telomeric DNA binding
    		•  0.594907498313479 bayes_pls_golite062009
  • aminoacyl-tRNA ligase activity
    		•  0.474251377131502 bayes_pls_golite062009
  • ligase activity, forming carbon-oxygen bonds
    		•  0.47336621289748 bayes_pls_golite062009
  • ligase activity, forming aminoacyl-tRNA and related compounds
    		•  0.47336621289748 bayes_pls_golite062009
  • RNA polymerase activity
    		•  0.39251242706379 bayes_pls_golite062009
  • DNA-directed RNA polymerase activity
    		•  0.39251242706379 bayes_pls_golite062009
  • ribonuclease activity
    		•  0.35186207828037 bayes_pls_golite062009
  • nuclease activity
    		•  0.26446253803519 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.64

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle