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Protein Overview: daf-16

General Information:
Name(s) found: daf-16 / CE38723 [WormBase]
Description(s) found:
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  • WBGene00000912 locus:daf-16 status:Partially_confirmed [WormBase]
  • gi|71989794|ref|NP_001021598.1| abnormal DAuer Formation family member (daf-16) [Caenorhabditis elegans] [NCBI NR]
  • gi|239977319|sp|O16850.2|FOXO_CAEEL RecName: Full=Forkhead box protein O; Short=FOXO; AltName: Full=Abnormal dauer formation protein 16 [NCBI NR]
  • Forkhead box protein O OS=Caenorhabditis elegans GN=daf-16 PE=1 SV=2 [Swiss-Prot]
  • CE38723 WBGene00000912 locus:daf-16 status:Partially_confirmed [wormpep150.fasta]
  • 38723 WBGene00000912 locus:daf-16 status:Partially_confirmed [wormpep150-phg-orf-ecoli-rand.fasta]
  • CE38723 WBGene00000912 locus:daf-16 status:Partially_confirmed [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE38723 WBGene00000912 locus:daf-16 status:Partially_confirmed| [wormORF-contam.fasta]
  • abnormal DAuer Formation family member (daf-16) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
    • Organism: Caenorhabditis elegans
    Length: 568 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed articleLink to PubMed article][IEALink to PubMed article]
    cytoplasm [IDALink to PubMed articleLink to PubMed article]
    Biological Process: response to heat [IEPLink to PubMed article]
    dauer larval development [IGILink to PubMed article]
    insulin receptor signaling pathway [IDALink to PubMed article]
    determination of adult lifespan [IGILink to PubMed article][IMPLink to PubMed article]
    regulation of transcription, DNA-dependent [IEALink to PubMed article]
    positive regulation of transcription from RNA polymerase II promoter [IDALink to PubMed article]
    Molecular Function: transcription factor activity [IDALink to PubMed article][IEALink to PubMed article]
    protein binding [IPILink to PubMed article]
    sequence-specific DNA binding [IDALink to PubMed article][IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQAWNCREVW RRIRKHLAHT SRTTVYSQFK FQIFEIFFQS FFPIFLHFAA KNSCFEPDFL  60
   61 DSPLPSDITL HNLEPARPDS GMSFSTDFDD DFFNLDLHQQ ERSASFGGVT QYSQQFLREK 120
  121 CSFSPYFHTS LETVDSGRTS LYGSNEQCGQ LGGASSNGST AMLHTPDGSN SHQTSFPSDF 180
  181 RMSESPDDTV SGKKTTTRRN AWGNMSYAEL ITTAIMASPE KRLTLAQVYE WMVQNVPYFR 240
  241 DKGDSNSSAG WKNSIRHNLS LHSRFMRIQN EGAGKSSWWV INPDAKPGRN PRRTRERSNT 300
  301 IETTTKAQLE KSRRGAKKRI KERALMGSLH STLNGNSIAG SIQTISHDLY DDDSMQGAFD 360
  361 NVPSSFRPRT QSNLSIPGSS SRVSPAIGSD IYDDLEFPSW VGESVPAIPS DIVDRTDQMR 420
  421 IDATTHIGGV QIKQESKPIK TEPIAPPPSY HELNSVRGSC AQNPLLRNPI VPSTNFKPMP 480
  481 LPGAYGNYQN GGITPINWLS TSNSSPLPGI QSCGIVAAQH TVASSSALPI DLENLTLPDQ 540
  541 PLMDTMDVDA LIRHELSQAG GQHIHFDL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..176] MSA 2.293997 View MSA. No confident structure predictions are available.
    2 View Details [177..353] PSI-BLAST 23.39794 Afx (Foxo4)
    3 View Details [354..568] MSA 6.417997 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  0.835523092977445 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.4843036104266 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.37117756729668 bayes_pls_golite062009
  • DNA binding
    		•  0.3118855114645 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.79

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle