Protein Overview: fbl-1

General Information:
Name(s) found:	fbl-1 / CE38374 [WormBase]
Description(s) found: Found 18 descriptions. SHOW ALL	WBGene00001403 locus:fbl-1 Fibulin-1 status:Confirmed UniProt:O77469 protein_id:CAA92962.2 [WormBase]
Organism:	Caenorhabditis elegans
Length:	728 amino acids
Gene Ontology:
Cellular Component:	extracellular region [IEA] proteinaceous extracellular matrix [IC]
Biological Process:	extracellular matrix organization [ISS] blood coagulation [IEA]
Molecular Function:	calcium ion binding [IEA] serine-type endopeptidase activity [IEA] extracellular matrix structural constituent [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRICFLLLAF LVAETFANEL TRCCAGGTRH FKNSNTCSSI KSEGTSMTCQ RAASICCLRS  60
   61 LLDNACDSGT DIAKEEESCP SNINILGGGL KKECCDCCLL AKDLLNRNEP CVAPVGFSAG 120
  121 CLRSFNKCCN GDIEITHASE IITGRPLNDP HVLHLGDRCA SSHCEHLCHD RGGEKVECSC 180
  181 RSGFDLAPDG MACVDRNECL TRQSPCTQSE DCVNTIGGYI CQRRISRLVP HRHRANRIGN 240
  241 APRRMRDDPY SRAGEYREAS QANTEFGCPM GWLFQHGHCV DVDECNLGSH DCGPLYQCRN 300
  301 TQGSYRCDAK KCGDGELQNP MTGECTSITC PNGYYPKNGM CNDIDECVTG HNCGAGEECV 360
  361 NTPGSFRCQQ KGNLCAHGYE VNGATGFCED VNECQQGVCG SMECINLPGT YKCKCGPGYE 420
  421 FNDAKKRCED VDECIKFAGH VCDLSAECIN TIGSFECKCK PGFQLASDGR RCEDVNECTT 480
  481 GIAACEQKCV NIPGSYQCIC DRGFALGPDG TKCEDIDECS IWAGSGNDLC MGGCINTKGS 540
  541 YLCQCPPGYK IQPDGRTCVD VDECAMGECA GSDKVCVNTL GSFKCHSIDC PTNYIHDSLN 600
  601 KNQIADGYSC IKVCSTEDTE CLGNHTREVL YQFRAVPSLK TIISPIEVSR IVTHMGVPFS 660
  661 VDYNLDYVGQ RHFRIVQERN IGIVQLVKPI SGPTVETIKV NIHTKSRTGV ILAFNEAIIE 720
  721 ISVSKYPF

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..195]	PSI-BLAST	3.09691	No description for 2dtgE was found.
2	View Details	[196..570]	PSI-BLAST	19.0	Low density lipoprotein (LDL) receptor YWTD domain; Low density lipoprotein (LDL) receptor, different EGF domains; Ligand-binding domain of low-density lipoprotein receptor
3	View Details	[571..728]	FFAS03	2.86	Activated protein c (autoprothrombin IIa)

Functions predicted (by domain):

#

Gene Ontology predictions

1

Term	Confidence	Notes
growth factor binding	4.27465167431259	bayes_pls_golite062009
insulin-like growth factor binding	4.02348040390921	bayes_pls_golite062009
protein binding	3.04595153576805	bayes_pls_golite062009
binding	2.46953677547264	bayes_pls_golite062009
insulin-like growth factor I binding	2.25070305389602	bayes_pls_golite062009
insulin-like growth factor II binding	1.29233483287178	bayes_pls_golite062009
protein tyrosine phosphatase activator activity	0.92638446697292	bayes_pls_golite062009
phosphatase activator activity	0.234175951765568	bayes_pls_golite062009

2

Term	Confidence	Notes
receptor binding	4.33045214660893	bayes_pls_golite062009
extracellular matrix structural constituent	3.98005075037205	bayes_pls_golite062009
growth factor activity	3.53240291240997	bayes_pls_golite062009
protein binding	3.02592228806142	bayes_pls_golite062009
ErbB-2 class receptor binding	2.42443754640644	bayes_pls_golite062009
binding	2.33940742543305	bayes_pls_golite062009
glycosaminoglycan binding	2.04860930279383	bayes_pls_golite062009
ErbB-3 class receptor binding	1.94863441611642	bayes_pls_golite062009
heparin binding	1.68224847671034	bayes_pls_golite062009
polysaccharide binding	1.52943230565474	bayes_pls_golite062009
pattern binding	1.40261567769805	bayes_pls_golite062009
epidermal growth factor receptor binding	1.07113751916821	bayes_pls_golite062009
carbohydrate binding	0.37481112933019	bayes_pls_golite062009
transcription regulator activity	0.282532662545359	bayes_pls_golite062009
transcription factor binding	0.25804698792789	bayes_pls_golite062009
transcription cofactor activity	0.154111600670615	bayes_pls_golite062009

3

Term	Confidence	Notes
receptor binding	3.99541876330624	bayes_pls_golite062009
extracellular matrix structural constituent	3.85002956705444	bayes_pls_golite062009
growth factor activity	3.14258960655219	bayes_pls_golite062009
protein binding	2.87649191391668	bayes_pls_golite062009
binding	2.2422088916225	bayes_pls_golite062009
ErbB-2 class receptor binding	1.82603324813818	bayes_pls_golite062009
glycosaminoglycan binding	1.79528213050973	bayes_pls_golite062009
heparin binding	1.40326733979777	bayes_pls_golite062009
ErbB-3 class receptor binding	1.3789475655616	bayes_pls_golite062009
polysaccharide binding	1.29534342979498	bayes_pls_golite062009
pattern binding	1.18858604250595	bayes_pls_golite062009
epidermal growth factor receptor binding	0.551960624416828	bayes_pls_golite062009
carbohydrate binding	0.221914592276874	bayes_pls_golite062009
transcription regulator activity	0.212747699806043	bayes_pls_golite062009
transcription factor binding	0.031856897261354	bayes_pls_golite062009

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

Philius confidence legend

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