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View Structure Prediction Details

Protein: fbl-1
Organism: Caenorhabditis elegans
Length: 728 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for fbl-1.

Description E-value Query
Range		 Subject
Range
gi|68440657 - gi|68440657|ref|XP_688293.1| PREDICTED: similar to secreted protein SST3 [Danio rerio]
 371.0 [0..37] [644..2004]

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Predicted Domain #1
Region A:
Residues: [1-195] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRICFLLLAF LVAETFANEL TRCCAGGTRH FKNSNTCSSI KSEGTSMTCQ RAASICCLRS  60
   61 LLDNACDSGT DIAKEEESCP SNINILGGGL KKECCDCCLL AKDLLNRNEP CVAPVGFSAG 120
  121 CLRSFNKCCN GDIEITHASE IITGRPLNDP HVLHLGDRCA SSHCEHLCHD RGGEKVECSC 180
  181 RSGFDLAPDG MACVD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.09691
Match: 2dtgE
Description: No description for 2dtgE was found.

Predicted functions:

Term Confidence Notes
growth factor binding 4.27465167431259 bayes_pls_golite062009
insulin-like growth factor binding 4.02348040390921 bayes_pls_golite062009
protein binding 3.04595153576805 bayes_pls_golite062009
binding 2.46953677547264 bayes_pls_golite062009
insulin-like growth factor I binding 2.25070305389602 bayes_pls_golite062009
insulin-like growth factor II binding 1.29233483287178 bayes_pls_golite062009
protein tyrosine phosphatase activator activity 0.92638446697292 bayes_pls_golite062009
phosphatase activator activity 0.234175951765568 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [196-570] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RNECLTRQSP CTQSEDCVNT IGGYICQRRI SRLVPHRHRA NRIGNAPRRM RDDPYSRAGE  60
   61 YREASQANTE FGCPMGWLFQ HGHCVDVDEC NLGSHDCGPL YQCRNTQGSY RCDAKKCGDG 120
  121 ELQNPMTGEC TSITCPNGYY PKNGMCNDID ECVTGHNCGA GEECVNTPGS FRCQQKGNLC 180
  181 AHGYEVNGAT GFCEDVNECQ QGVCGSMECI NLPGTYKCKC GPGYEFNDAK KRCEDVDECI 240
  241 KFAGHVCDLS AECINTIGSF ECKCKPGFQL ASDGRRCEDV NECTTGIAAC EQKCVNIPGS 300
  301 YQCICDRGFA LGPDGTKCED IDECSIWAGS GNDLCMGGCI NTKGSYLCQC PPGYKIQPDG 360
  361 RTCVDVDECA MGECA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 19.0
Match: 1n7dA
Description: Low density lipoprotein (LDL) receptor YWTD domain; Low density lipoprotein (LDL) receptor, different EGF domains; Ligand-binding domain of low-density lipoprotein receptor
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
receptor binding 4.33045214660893 bayes_pls_golite062009
extracellular matrix structural constituent 3.98005075037205 bayes_pls_golite062009
growth factor activity 3.53240291240997 bayes_pls_golite062009
protein binding 3.02592228806142 bayes_pls_golite062009
ErbB-2 class receptor binding 2.42443754640644 bayes_pls_golite062009
binding 2.33940742543305 bayes_pls_golite062009
glycosaminoglycan binding 2.04860930279383 bayes_pls_golite062009
ErbB-3 class receptor binding 1.94863441611642 bayes_pls_golite062009
heparin binding 1.68224847671034 bayes_pls_golite062009
polysaccharide binding 1.52943230565474 bayes_pls_golite062009
pattern binding 1.40261567769805 bayes_pls_golite062009
epidermal growth factor receptor binding 1.07113751916821 bayes_pls_golite062009
carbohydrate binding 0.37481112933019 bayes_pls_golite062009
transcription regulator activity 0.282532662545359 bayes_pls_golite062009
transcription factor binding 0.25804698792789 bayes_pls_golite062009
transcription cofactor activity 0.154111600670615 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [571-728] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSDKVCVNTL GSFKCHSIDC PTNYIHDSLN KNQIADGYSC IKVCSTEDTE CLGNHTREVL  60
   61 YQFRAVPSLK TIISPIEVSR IVTHMGVPFS VDYNLDYVGQ RHFRIVQERN IGIVQLVKPI 120
  121 SGPTVETIKV NIHTKSRTGV ILAFNEAIIE ISVSKYPF

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.86
Match: 1autL
Description: Activated protein c (autoprothrombin IIa)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
receptor binding 3.99541876330624 bayes_pls_golite062009
extracellular matrix structural constituent 3.85002956705444 bayes_pls_golite062009
growth factor activity 3.14258960655219 bayes_pls_golite062009
protein binding 2.87649191391668 bayes_pls_golite062009
binding 2.2422088916225 bayes_pls_golite062009
ErbB-2 class receptor binding 1.82603324813818 bayes_pls_golite062009
glycosaminoglycan binding 1.79528213050973 bayes_pls_golite062009
heparin binding 1.40326733979777 bayes_pls_golite062009
ErbB-3 class receptor binding 1.3789475655616 bayes_pls_golite062009
polysaccharide binding 1.29534342979498 bayes_pls_golite062009
pattern binding 1.18858604250595 bayes_pls_golite062009
epidermal growth factor receptor binding 0.551960624416828 bayes_pls_golite062009
carbohydrate binding 0.221914592276874 bayes_pls_golite062009
transcription regulator activity 0.212747699806043 bayes_pls_golite062009
transcription factor binding 0.031856897261354 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle