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Protein Overview: hif-1

General Information:
Name(s) found: hif-1 / CE38181 [WormBase]
Description(s) found:
Found 16 descriptions.
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  • WBGene00001851 locus:hif-1 Hypoxia-inducible factor 1 status:Confirmed UniProt:G5EGD2 protein_id:CAD54141.2 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 665 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article][IEALink to PubMed article]
    Biological Process: response to hypoxia [IMPLink to PubMed article]
    signal transduction [IEALink to PubMed article]
    regulation of transcription, DNA-dependent [IEALink to PubMed article]
    regulation of transcription [IEALink to PubMed article]
    Molecular Function: transcription factor activity [ISSLink to PubMed article]
    transcription regulator activity [IEALink to PubMed article]
    signal transducer activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEDNRKRNME RRRETSRHAA RDRRSKESDI FDDLKMCVPI VEEGTVTHLD RIALLRVAAT  60
   61 ICRLRKTAGN VLENNLDNEI TNEVWTEDTI AECLDGFVMI VDSDSSILYV TESVAMYLGL 120
  121 TQTDLTGRAL RDFLHPSDYD EFDKQSKMLH KPRGEDTDTT GINMVLRMKT VISPRGRCLN 180
  181 LKSALYKSVS FLVHSKVSTG GHVSFMQGIT IPAGQGTTNA NASAMTKYTE SPMGAFTTRH 240
  241 TCDMRITFVS DKFNYILKSE LKTLMGTSFY ELVHPADMMI VSKSMKELFA KGHIRTPYYR 300
  301 LIAANDTLAW IQTEATTITH TTKGQKGQYV ICVHYVLGIQ GAEESLVVCT DSMPAGMQVD 360
  361 IKKEVDDTRD YIGRQPEIVE CVDFTPLIEP EDPFDTVIEP VVGGEEPVKQ ADMGIYSVTD 420
  421 EYEQRVYGQI SAGNDIEDCD MDSDTESIED SGLAPEFDVD LAPIYNEKME VDGEDEDGGE 480
  481 EEHVRTATMT FCNGFFATSQ ALRRRHATGQ RTASGQPNRR ISVPLWPRRT SWIRHLVPPD 540
  541 RRHHTDEEHK VREVEQLDRL PRQHRPHCHT VPTTRHLQRA SHNVDLTVPR VSNLDKSCTE 600
  601 TLDLWDVAAI RPIRHDAFPP FHHQILSMCR PLEASTQSSE AMMCSPLCLL PILSPLPKGS 660
  661 IRRQH

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..75] FFAS03 3.12 Solution Structure of Max B-HLH-LZ
    2 View Details [76..497] PSI-BLAST 37.522879 Crystal Structure of the PAS repeat region of the Drosophila clock protein PERIOD
    3 View Details [498..665] PSI-BLAST 14.69897 No description for 2r6oA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  5.08855036296174 bayes_pls_golite062009
  • DNA binding
    		•  4.87243318281876 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.77537175825177 bayes_pls_golite062009
  • transcription factor activity
    		•  4.43134840465732 bayes_pls_golite062009
  • binding
    		•  3.63719401349018 bayes_pls_golite062009
  • transcription factor binding
    		•  2.33137487648005 bayes_pls_golite062009
  • transcription activator activity
    		•  2.29259809049377 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.21218632195974 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.06903182404145 bayes_pls_golite062009
  • protein binding
    		•  1.48748521104247 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.30186253699056 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity, enhancer binding
    		•  1.05281795983217 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.828519845330998 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.560586077390024 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.172100901723138 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.86

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle