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View Structure Prediction Details

Protein: hif-1
Organism: Caenorhabditis elegans
Length: 665 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for hif-1.

Description E-value Query
Range
Subject
Range
gi|114577237 - gi|114577237|ref|XP_001147074.1| PREDICTED: endothelial PAS domain protein 1 isoform 2 [Pan troglody...
301.0 [0..2] [654..5]

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Predicted Domain #1
Region A:
Residues: [1-75]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEDNRKRNME RRRETSRHAA RDRRSKESDI FDDLKMCVPI VEEGTVTHLD RIALLRVAAT  60
   61 ICRLRKTAGN VLENN

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 3.12
Match: 1r05A
Description: Solution Structure of Max B-HLH-LZ
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.08855036296174 bayes_pls_golite062009
DNA binding 4.87243318281876 bayes_pls_golite062009
nucleic acid binding 4.77537175825177 bayes_pls_golite062009
transcription factor activity 4.43134840465732 bayes_pls_golite062009
binding 3.63719401349018 bayes_pls_golite062009
transcription factor binding 2.33137487648005 bayes_pls_golite062009
transcription activator activity 2.29259809049377 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.21218632195974 bayes_pls_golite062009
sequence-specific DNA binding 2.06903182404145 bayes_pls_golite062009
protein binding 1.48748521104247 bayes_pls_golite062009
transcription cofactor activity 1.30186253699056 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 1.05281795983217 bayes_pls_golite062009
transcription repressor activity 0.828519845330998 bayes_pls_golite062009
transcription corepressor activity 0.560586077390024 bayes_pls_golite062009
transcription coactivator activity 0.172100901723138 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [76-497]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LDNEITNEVW TEDTIAECLD GFVMIVDSDS SILYVTESVA MYLGLTQTDL TGRALRDFLH  60
   61 PSDYDEFDKQ SKMLHKPRGE DTDTTGINMV LRMKTVISPR GRCLNLKSAL YKSVSFLVHS 120
  121 KVSTGGHVSF MQGITIPAGQ GTTNANASAM TKYTESPMGA FTTRHTCDMR ITFVSDKFNY 180
  181 ILKSELKTLM GTSFYELVHP ADMMIVSKSM KELFAKGHIR TPYYRLIAAN DTLAWIQTEA 240
  241 TTITHTTKGQ KGQYVICVHY VLGIQGAEES LVVCTDSMPA GMQVDIKKEV DDTRDYIGRQ 300
  301 PEIVECVDFT PLIEPEDPFD TVIEPVVGGE EPVKQADMGI YSVTDEYEQR VYGQISAGND 360
  361 IEDCDMDSDT ESIEDSGLAP EFDVDLAPIY NEKMEVDGED EDGGEEEHVR TATMTFCNGF 420
  421 FA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 37.522879
Match: 1wa9A
Description: Crystal Structure of the PAS repeat region of the Drosophila clock protein PERIOD
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [498-665]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TSQALRRRHA TGQRTASGQP NRRISVPLWP RRTSWIRHLV PPDRRHHTDE EHKVREVEQL  60
   61 DRLPRQHRPH CHTVPTTRHL QRASHNVDLT VPRVSNLDKS CTETLDLWDV AAIRPIRHDA 120
  121 FPPFHHQILS MCRPLEASTQ SSEAMMCSPL CLLPILSPLP KGSIRRQH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 14.69897
Match: 2r6oA
Description: No description for 2r6oA was found.

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