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Protein Overview: nas-36

General Information:
Name(s) found: nas-36 / CE38281 [WormBase]
Description(s) found:
Found 15 descriptions.
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  • WBGene00003552 locus:nas-36 Zinc metalloproteinase nas-36 status:Confirmed UniProt:Q18206 protein_id:CAA96596.2 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 617 amino acids

    Gene Ontology:
    Cellular Component: membrane [IEALink to PubMed article]
    Biological Process: molting cycle, protein-based cuticle [IMPLink to PubMed article]
    locomotory behavior [IMPLink to PubMed article]
    proteolysis [IEALink to PubMed article]
    Molecular Function: meprin A activity [IEALink to PubMed article]
    zinc ion binding [IEALink to PubMed article]
    astacin activity [IEALink to PubMed article]
    metallopeptidase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRLCHSIILF NSLISISICS KADDPALLVA SEFKEHFNVE EKQLETVEEL LIKMKKLAHS  60
   61 RSFKGREFGH DAVEDSKKEV AISTQQGTIN KKVSPFLFEG DIFLSRRQAV DILKALSKDK 120
  121 TKRLRRSFVS DKTATWKTMP IKYRFHESID FYTISQIIAA IRFWEDSTCI TFENVSDSPD 180
  181 GDYIEFFSGQ GCYSMIGRNG GRQGISIGES CVKMGVIEHE IGHALGLWHE QSRPDALGYV 240
  241 TIERDFILPS YISDFLQRDD EIDTLGIPYD LGSVMHYGST AFSVDQKSKT VVTRDSLYQQ 300
  301 TIGQREKLSF YDVATINTAY CKDECKSEKT KCENGGYMRP SKCSECLCPD GLGGEKCEKN 360
  361 EDSKNAECGG IIKLTEEWKE IESPNYPDPG YEADQKCSWL LKAEKGKRVE IEFIEDFSFL 420
  421 CTSTCVDFVE LKISDDLRNT GFRFCCYDKP EISFVSQTDT AIIIFRSQLS TDIGFKIQAK 480
  481 STDAEPRTTI APTIITTTLA PITVDAPNVW ADWGEWSMCS RTCGGCGIRS RVRSCRSKKC 540
  541 EGRRQEFGTC NLKACPVDKH CAKLLSNNRL CNGKVCTKND IAISSCDAPQ CCPPFINVDG 600
  601 VCQSDQENQH DELWLSI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..74] deduced N/A No confident structure predictions are available.
    2 View Details [75..324] PSI-BLAST 41.0 STRUCTURE OF ASTACIN AND IMPLICATIONS FOR ACTIVATION OF ASTACINS AND ZINC-LIGATION OF COLLAGENASES
    3 View Details [325..617] PSI-BLAST 10.09691 Low density lipoprotein (LDL) receptor YWTD domain; Low density lipoprotein (LDL) receptor, different EGF domains; Ligand-binding domain of low-density lipoprotein receptor

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • peptidase activity
    		•  3.87713655504947 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  3.50720289959102 bayes_pls_golite062009
  • metallopeptidase activity
    		•  2.55317823694462 bayes_pls_golite062009
  • endopeptidase activity
    		•  2.52973705827479 bayes_pls_golite062009
  • hydrolase activity
    		•  2.30803642767787 bayes_pls_golite062009
  • metalloendopeptidase activity
    		•  1.81132179546381 bayes_pls_golite062009
  • catalytic activity
    		•  1.26162753036584 bayes_pls_golite062009
  • exopeptidase activity
    		•  0.71491631246151 bayes_pls_golite062009
  • binding
    		•  0.210557818016724 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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