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Protein Overview: nhr-12

General Information:
Name(s) found: nhr-12 / CE40989 [WormBase]
Description(s) found:
Found 10 descriptions.
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  • WBGene00003611 locus:nhr-12 status:Partially_confirmed UniProt:A5JYT1 protein_id:CAN86639.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 456 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEALink to PubMed article]
    Biological Process: regulation of transcription, DNA-dependent [IEALink to PubMed article]
    Molecular Function: transcription factor activity [IEALink to PubMed article]
    zinc ion binding [IEALink to PubMed article]
    steroid hormone receptor activity [IEALink to PubMed article]
    sequence-specific DNA binding [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEQIPQEQKT EPFLASFTTT EKLGTETPTT SITPNTQFRG RYEKPNCAVC NEVGDGLHFG  60
   61 AEACRACTAF FRRSVALSKK YECRAGRNCE VSSNIRCMCR SCRYDKCIEV GMNPECVQNR 120
  121 RENDTPKADL QFDTSKTEIR RPIPNFNIVP QASAVPSTSN FMDFSIFKDT PISNFSAFSP 180
  181 ASLPGLSSSP SLETMPLLER MRINYDKMEN ARNVIHRREG ENIFQQKVPR AITFREATEV 240
  241 TTKEVSLVAD WIEWCFDDFG LLPVDQKTIL FQNFFVFFCM LERAFMTVKS GRDGIVVMAS 300
  301 KDYIDYDNLE GFFKECNSGT GGTPAEIAKL CRLIRPSFEL QKRSLINLMR LENVDSYEFF 360
  361 ALCVMLFWDF GLEGQSDECN EVGRRVKHRV TREMTFYLRN VKKHEEPLYR MASVVSILPS 420
  421 LQRAVRRFQE DIEMANIFNI YALPENFVNI INGKFN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..102] PSI-BLAST 22.09691 No description for 2hanB was found.
    2 View Details [103..456] PSI-BLAST 33.0 hemipteran ecdysone receptor ligand-binding domain complexed with ponasterone A

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  4.00967542385368 bayes_pls_golite062009
  • DNA binding
    		•  3.60745514727532 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.47256374293954 bayes_pls_golite062009
  • binding
    		•  2.96409924710655 bayes_pls_golite062009
  • transcription activator activity
    		•  2.9532663930699 bayes_pls_golite062009
  • transcription factor activity
    		•  2.90769972671972 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.72967350701574 bayes_pls_golite062009
  • protein binding
    		•  2.44501340584871 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.40923942043513 bayes_pls_golite062009
  • ligand-dependent nuclear receptor activity
    		•  1.49515149729803 bayes_pls_golite062009
  • transcription factor binding
    		•  1.38523780690867 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.26452462867497 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.68943696300126 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.58115018700114 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.256420113528322 bayes_pls_golite062009
  • catalytic activity
    		•  0.101795606736461 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle