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View Structure Prediction Details

Protein: nhr-12
Organism: Caenorhabditis elegans
Length: 456 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for nhr-12.

Description E-value Query
Range
Subject
Range
gi|73967652 - gi|73967652|ref|XP_548399.2| PREDICTED: similar to Retinoic acid receptor RXR-alpha (Retinoid X rece...
300.0 [0..3] [453..20]

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Predicted Domain #1
Region A:
Residues: [1-102]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEQIPQEQKT EPFLASFTTT EKLGTETPTT SITPNTQFRG RYEKPNCAVC NEVGDGLHFG  60
   61 AEACRACTAF FRRSVALSKK YECRAGRNCE VSSNIRCMCR SC

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 22.09691
Match: 2hanB
Description: No description for 2hanB was found.

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.00967542385368 bayes_pls_golite062009
DNA binding 3.60745514727532 bayes_pls_golite062009
nucleic acid binding 3.47256374293954 bayes_pls_golite062009
binding 2.96409924710655 bayes_pls_golite062009
transcription activator activity 2.9532663930699 bayes_pls_golite062009
transcription factor activity 2.90769972671972 bayes_pls_golite062009
sequence-specific DNA binding 2.72967350701574 bayes_pls_golite062009
protein binding 2.44501340584871 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.40923942043513 bayes_pls_golite062009
ligand-dependent nuclear receptor activity 1.49515149729803 bayes_pls_golite062009
transcription factor binding 1.38523780690867 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.26452462867497 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.68943696300126 bayes_pls_golite062009
transcription cofactor activity 0.58115018700114 bayes_pls_golite062009
transcription repressor activity 0.256420113528322 bayes_pls_golite062009
catalytic activity 0.101795606736461 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [103-456]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RYDKCIEVGM NPECVQNRRE NDTPKADLQF DTSKTEIRRP IPNFNIVPQA SAVPSTSNFM  60
   61 DFSIFKDTPI SNFSAFSPAS LPGLSSSPSL ETMPLLERMR INYDKMENAR NVIHRREGEN 120
  121 IFQQKVPRAI TFREATEVTT KEVSLVADWI EWCFDDFGLL PVDQKTILFQ NFFVFFCMLE 180
  181 RAFMTVKSGR DGIVVMASKD YIDYDNLEGF FKECNSGTGG TPAEIAKLCR LIRPSFELQK 240
  241 RSLINLMRLE NVDSYEFFAL CVMLFWDFGL EGQSDECNEV GRRVKHRVTR EMTFYLRNVK 300
  301 KHEEPLYRMA SVVSILPSLQ RAVRRFQEDI EMANIFNIYA LPENFVNIIN GKFN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 33.0
Match: 1z5xE
Description: hemipteran ecdysone receptor ligand-binding domain complexed with ponasterone A
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle