Protein Overview: CE46852

General Information:
Name(s) found:	CE46852 [WormBase]
Description(s) found: SHOW ONLY BEST	WBGene00000898 locus:daf-2 Insulin-like receptor status:Confirmed UniProt:Q968Y9 protein_id:CCD72201.2 [WormBase] Insulin-like receptor OS=Caenorhabditis elegans GN=daf-2 PE=1 SV=2 [Swiss-Prot] [wormpep130-phg-ecoli-orf-rand.fasta] [wormORF-contam.fasta] CE46852 WBGene00000898 locus:daf-2 status:Confirmed UniProt:Q968Y9 protein_id:CCD72201.2 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta] CE46852 WBGene00000898 locus:daf-2 status:Confirmed UniProt:Q968Y9 protein_id:CCD72201.2 Insulin-like receptor [wormpep246-ecoli-contam.fasta]
Organism:	Caenorhabditis elegans
Length:	1846 amino acids
Gene Ontology:
Cellular Component:	membrane [IEA] integral to membrane [IEA]
Biological Process:	lipid storage [IMP] dauer larval development [IMP] locomotion [IMP] insulin receptor signaling pathway [ISS] determination of adult lifespan [IMP] positive regulation of growth rate [IMP] transmembrane receptor protein tyrosine kinase signaling pathway [IEA] protein amino acid autophosphorylation [ISS] negative regulation of transcription factor import into nucleus [IGI][IMP] protein amino acid phosphorylation [IEA] reproduction [IMP] response to heat [IMP] dauer entry [IMP] dauer exit [IMP] negative regulation of gene-specific transcription from RNA polymerase II promoter [IMP]
Molecular Function:	ATP binding [IEA][ISS] protein tyrosine kinase activity [IEA] protein binding [IEA] insulin receptor activity [ISS] transmembrane receptor protein tyrosine kinase activity [IEA] protein kinase activity [IEA] peptide hormone binding [ISS] protein serine/threonine kinase activity [IEA] SH2 domain binding [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTRMNIVRCR RRHKILENLE EENLGPSCSS TTSTTAATEA LGTTTEDMRL KQQRSSSRAT  60
   61 EHDIVDGNHH DDEHITMRRL RLVKNSRTRR RTTPDSSMDC YEENPPSQKT SINYSWISKK 120
  121 SSMTSLMLLL LFAFVQPCAS IVEKRCGPID IRNRPWDIKP QWSKLGDPNE KDLAGQRMVN 180
  181 CTVVEGSLTI SFVLKHKTKA QEEMHRSLQP RYSQDEFITF PHLREITGTL LVFETEGLVD 240
  241 LRKIFPNLRV IGGRSLIQHY ALIIYRNPDL EIGLDKLSVI RNGGVRIIDN RKLCYTKTID 300
  301 WKHLITSSIN DVVVDNAAEY AVTETGLMCP RGACEEDKGE SKCHYLEEKN QEQGVERVQS 360
  361 CWSNTTCQKS CAYDRLLPTK EIGPGCDANG DRCHDQCVGG CERVNDATAC HACKNVYHKG 420
  421 KCIEKCDAHL YLLLQRRCVT REQCLQLNPV LSNKTVPIKA TAGLCSDKCP DGYQINPDDH 480
  481 RECRKCVGKC EIVCEINHVI DTFPKAQAIR LCNIIDGNLT IEIRGKQDSG MASELKDIFA 540
  541 NIHTITGYLL VRQSSPFISL NMFRNLRRIE AKSLFRNLYA ITVFENPNLK KLFDSTTDLT 600
  601 LDRGTVSIAN NKMLCFKYIK QLMSKLNIPL DPIDQSEGTN GEKAICEDMA INVSITAVNA 660
  661 DSVFFSWPSF NITDIDQRKF LGYELFFKEV PRIDENMTIE EDRSACVDSW QSVFKQYYET 720
  721 SNGEPTPDIF MDIGPRERIR PNTLYAYYVA TQMVLHAGAK NGVSKIGFVR TSYYTPDPPT 780
  781 LALAQVDSDA IHITWEAPLQ PNGDLTHYTI MWRENEVSPY EEAEKFCTDA STPANRQHTK 840
  841 DPKETIVADK PVDIPSSRTV APTLLTMMGH EDQQKTCAAT PGCCSCSAIE ESSEQNKKKR 900
  901 PDPMSAIESS AFENKLLDEV LMPRDTMRVR RSIEDANRVS EELEKAENLG KAPKTLGGKK 960
  961 PLIHISKKKP SSSSTTSTPA PTIASMYALT RKPTTVPGTR IRLYEIYEPL PGSWAINVSA1020
 1021 LALDNSYVIR NLKHYTLYAI SLSACQNMTV PGASCSISHR AGALKRTKHI TDIDKVLNET1080
 1081 IEWRFMNNSQ QVNVTWDPPT EVNGGIFGYV VKLKSKVDGS IVMTRCVGAK RGYSTRNQGV1140
 1141 LFQNLADGRY FVSVTATSVH GAGPEAESSD PIVVMTPGFF TVEIILGMLL VFLILMSIAG1200
 1201 CIIYYYIQVR YGKKVKALSD FMQLNPEYCV DNKYNADDWE LRQDDVVLGQ QCGEGSFGKV1260
 1261 YLGTGNNVVS LMGDRFGPCA IKINVDDPAS TENLNYLMEA NIMKNFKTNF IVKLYGVIST1320
 1321 VQPAMVVMEM MDLGNLRDYL RSKREDEVFN ETDCNFFDII PRDKFHEWAA QICDGMAYLE1380
 1381 SLKFCHRDLA ARNCMINRDE TVKIGDFGMA RDLFYHDYYK PSGKRMMPVR WMSPESLKDG1440
 1441 KFDSKSDVWS FGVVLYEMVT LGAQPYIGLS NDEVLNYIGM ARKVIKKPEC CENYWYKVMK1500
 1501 MCWRYSPRDR PTFLQLVHLL AAEASPEFRD LSFVLTDNQM ILDDSEALDL DDIDDTDMND1560
 1561 QVVEVAPDVE NVEVQSDSER RNTDSIPLKQ FKTIPPINAT TSHSTISIDE TPMKAKQREG1620
 1621 SLDEEYALMN HSGGPSDAEV RTYAGDGDYV ERDVRENDVP TRRNTGASTS SYTGGGPYCL1680
 1681 TNRGGSNERG AGFGEAVRLT DGVGSGHLND DDYVEKEISS MDTRRSTGAS SSSYGVPQTN1740
 1741 WSGNRGATYY TSKAQQAATA AAAAAAALQQ QQNGGRGDRL TQLPGTGHLQ STRGGQDGDY1800
 1801 IETEPKNYRN NGSPSRNGNS RDIFNGRSAF GENEHLIEDN EHHPLV

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: CE46852

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: