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Protein Overview: AK2H_ECOLI

General Information:
Name(s) found: AK2H_ECOLI [Swiss-Prot]
Description(s) found:
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  • gi|416596|sp|P00562.3|AK2H_ECOLI RecName: Full=Bifunctional aspartokinase/homoserine dehydrogenase 2; AltName: Full=Aspartokinase II/homoserine dehydrogenase II; Short=AKII-HDII; Includes: RecName: Full=Aspartokinase; Includes: RecName: Full=Homoserine de [NCBI NR]
  • gi|305043|gb|AAB03072.1| aspartokinase II/homoserine dehydrogenase II [Escherichia coli] [NCBI NR]
  • pir||DEECK2 metL bifunctional enzyme - Escherichia coli (strain K-12) [NCBI NR]
  • Bifunctional aspartokinase/homoserine dehydrogenase II (AKII-HDII) [Includes: Aspartokinase II (EC 2.7.2.4); Homoserine dehydrogenase II (EC 1.1.1.3)] - Escherichia coli [Swiss-Prot]
  • aspartokinase II and homoserine dehydrogenase II; bifunctional: aspartokinase II (N-terminal); homoserine dehydrogenase II (C-terminal) [Escherichia coli K12]gi|305043|gb|AAB03072.1| aspartokinase II/homoserine dehydrogenase II [Escherichia coli]gi|1790 [nrdb_11152004_Chlamydomonas]
  • Bifunctional aspartokinase/homoserine dehydrogenase 2 (Aspartokinase II/homoserine dehydrogenase II) (AKII-HDII) [Includes: Aspartokinase ; Homoserine dehydrogenase ] [NCBI-RefSeq_human_na_08-09-2006_reversed.fasta]
  • aspartokinase II/homoserine dehydrogenase II [Escherichia coli] [NCBI-RefSeq_human_na_08-09-2006_reversed.fasta]
  • Bifunctional aspartokinase/homoserine dehydrogenase 2 OS=Escherichia coli (strain K12) GN=metL PE=1 SV=3 [uniprot-Ecoli-reviewed-110511.fasta]
    • Organism: Escherichia coli
    Length: 810 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVIAQAGAK GRQLHKFGGS SLADVKCYLR VAGIMAEYSQ PDDMMVVSAA GSTTNQLINW  60
   61 LKLSQTDRLS AHQVQQTLRR YQCDLISGLL PAEEADSLIS AFVSDLERLA ALLDSGINDA 120
  121 VYAEVVGHGE VWSARLMSAV LNQQGLPAAW LDAREFLRAE RAAQPQVDEG LSYPLLQQLL 180
  181 VQHPGKRLVV TGFISRNNAG ETVLLGRNGS DYSATQIGAL AGVSRVTIWS DVAGVYSADP 240
  241 RKVKDACLLP LLRLDEASEL ARLAAPVLHA RTLQPVSGSE IDLQLRCSYT PDQGSTRIER 300
  301 VLASGTGARI VTSHDDVCLI EFQVPASQDF KLAHKEIDQI LKRAQVRPLA VGVHNDRQLL 360
  361 QFCYTSEVAD SALKILDEAG LPGELRLRQG LALVAMVGAG VTRNPLHCHR FWQQLKGQPV 420
  421 EFTWQSDDGI SLVAVLRTGP TESLIQGLHQ SVFRAEKRIG LVLFGKGNIG SRWLELFARE 480
  481 QSTLSARTGF EFVLAGVVDS RRSLLSYDGL DASRALAFFN DEAVEQDEES LFLWMRAHPY 540
  541 DDLVVLDVTA SQQLADQYLD FASHGFHVIS ANKLAGASDS NKYRQIHDAF EKTGRHWLYN 600
  601 ATVGAGLPIN HTVRDLIDSG DTILSISGIF SGTLSWLFLQ FDGSVPFTEL VDQAWQQGLT 660
  661 EPDPRDDLSG KDVMRKLVIL AREAGYNIEP DQVRVESLVP AHCEGGSIDH FFENGDELNE 720
  721 QMVQRLEAAR EMGLVLRYVA RFDANGKARV GVEAVREDHP LASLLPCDNV FAIESRWYRD 780
  781 NPLVIRGPGA GRDVTAGAIQ SDINRLAQLL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..454] PSI-BLAST 90.221849 No description for 2hmfA was found.
    2 View Details [455..810] PSI-BLAST 68.522879 Homoserine Dehydrogenase in complex with suicide inhibitor complex NAD-5-hydroxy-4-Oxonorvaline

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • acetolactate synthase activity
    		•  6.25735158730374 bayes_pls_golite062009
  • transferase activity, transferring aldehyde or ketonic groups
    		•  5.28856942236052 bayes_pls_golite062009
  • aspartate kinase activity
    		•  3.23731032633773 bayes_pls_golite062009
  • kinase activity
    		•  3.13431949100327 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  2.94061415123563 bayes_pls_golite062009
  • catalytic activity
    		•  2.83338756483354 bayes_pls_golite062009
  • phosphotransferase activity, carboxyl group as acceptor
    		•  2.65970393362911 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.54193538468834 bayes_pls_golite062009
  • amino acid kinase activity
    		•  2.38310367076654 bayes_pls_golite062009
  • transferase activity
    		•  2.34413838821786 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.77420728550693 bayes_pls_golite062009
  • DNA binding
    		•  1.70654139251388 bayes_pls_golite062009
  • binding
    		•  1.61057316956254 bayes_pls_golite062009
  • acetylglutamate kinase activity
    		•  1.28891782911186 bayes_pls_golite062009
  • transcription factor activity
    		•  1.13755026342338 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.61058430787131 bayes_pls_golite062009
  • glutamate 5-kinase activity
    		•  0.416864856459166 bayes_pls_golite062009
  • protein binding
    		•  0.178881469836152 bayes_pls_golite062009
    2
    Term Confidence Notes
  • aspartate-semialdehyde dehydrogenase activity
    		•  2.99580112154281 bayes_pls_golite062009
  • dihydrodipicolinate reductase activity
    		•  2.74085594134831 bayes_pls_golite062009
  • catalytic activity
    		•  2.54843319568228 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.90939908578582 bayes_pls_golite062009
  • oxidoreductase activity
    		•  1.84451425136793 bayes_pls_golite062009
  • DNA binding
    		•  1.61355789916908 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.48478425318425 bayes_pls_golite062009
  • binding
    		•  1.22114607236074 bayes_pls_golite062009
  • transcription factor activity
    		•  0.91090893050278 bayes_pls_golite062009
  • phosphoglycerate dehydrogenase activity
    		•  0.639509916626856 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors
    		•  0.610531769148819 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
    		•  0.610013758225609 bayes_pls_golite062009
  • saccharopine dehydrogenase activity
    		•  0.495113665163626 bayes_pls_golite062009
  • ketol-acid reductoisomerase activity
    		•  0.414784304540676 bayes_pls_golite062009
  • structural molecule activity
    		•  0.160242197882814 bayes_pls_golite062009
  • N-acetyl-gamma-glutamyl-phosphate reductase activity
    		•  0.0651785123513661 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle