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Protein Overview: FBpp0298328, FBp...

General Information:
Name(s) found: FBpp0298328 [FlyBase]
FBpp0298327 [FlyBase]
Description(s) found:
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  • gi|85724752|ref|NP_001033808.1| mitf, isoform A [Drosophila melanogaster] [NCBI NR]
  • gi|85724750|ref|NP_001033807.1| mitf, isoform B [Drosophila melanogaster] [NCBI NR]
  • gi|84795117|gb|ABC65835.1| mitf, isoform B [Drosophila melanogaster] [NCBI NR]
  • gi|84795116|gb|ABC65834.1| mitf, isoform A [Drosophila melanogaster] [NCBI NR]
  • gi|39840974|gb|AAR31123.1| RE45331p [Drosophila melanogaster] [NCBI NR]
  • gi|33286725|gb|AAQ01726.1| MITF [Drosophila melanogaster] [NCBI NR]
  • type=protein; loc=4:join(1219641..1219801,1223420..1223750,1223802..1223921,1223986..1224414,1224988..1225008,1225217..1225376,1225434..1225675,1225732..1225890,1225948..1226517); ID=FBpp0298328; name=Mitf-PB; parent=FBgn0263112,FBtr0307327; dbxref=REFSEQ:NP_001033807,GB_protein:ABC65835,FlyBase:FBpp0298328,FlyBase:FBpp0099753,FlyBase_Annotation_IDs:CG17469-PB,FlyBase_Annotation_IDs:CG43369-PB; MD5=ef00b3a47859809f853b0d711e45a3f4; length=730; release=r5.56; species=Dmel; [FlyBase]
  • type=protein; loc=4:join(1219641..1219801,1223420..1223750,1223802..1223921,1223986..1224414,1224988..1225008,1225217..1225376,1225434..1225675,1225732..1225890,1225948..1226517); ID=FBpp0298327; name=Mitf-PA; parent=FBgn0263112,FBtr0307326; dbxref=REFSEQ:NP_001033808,GB_protein:ABC65834,FlyBase:FBpp0298327,FlyBase:FBpp0099752,FlyBase_Annotation_IDs:CG17469-PA,FlyBase_Annotation_IDs:CG43369-PA; MD5=ef00b3a47859809f853b0d711e45a3f4; length=730; release=r5.56; species=Dmel; [FlyBase]
  • The gene Mitf is referred to in FlyBase by the symbol Dmel\Mitf (CG17469, FBgn0067895). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 4:1219484..1228193. It has the cytological map location 102F8. There is experimental evidence that it has the molecular function</span>: transcription regulator activity. There is experimental evidence that it is involved in the biological process</span>: regulation of transcription; compound eye morphogenesis. 3 alleles are reported. The phenotype of these alleles is annotated with: eye disc. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • RE45331p [Drosophila melanogaster]gi|33286725|gb|AAQ01726.1| MITF [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=4:join(1219641..1219801,1223420..1223750,1223802..1223921,1223986..1224414,1224988..1225008,1225217..1225376,1225434..1225675,1225732..1225890,1225948..1226517); ID=FBpp0099752; name=Mitf-PA; parent=FBgn0067895,FBtr0100347; dbxref=FlyBas [fly-100309-contam.fasta]
  • type=protein; loc=4:join(1219641..1219801,1223420..1223750,1223802..1223921,1223986..1224414,1224988..1225008,1225217..1225376,1225434..1225675,1225732..1225890,1225948..1226517); ID=FBpp0099753; name=Mitf-PB; parent=FBgn0067895,FBtr0100348; dbxref=FlyBas [fly-100309-contam.fasta]
  • MITF [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Mitf CG17469-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Mitf CG17469-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG17469-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG17469-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta]
  • RE45331p [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=4:join(1219641..1219801,1223420..1223750,1223802..1223921,1223986..1224414,1224988..1225008,1225217..1225376,1225434..1225675,1225732..1225890,1225948..1226517); ID=FBpp0099752; name=Mitf-PA; parent=FBgn0067895,FBtr0100347; dbxref=FlyBase_Annotation_IDs:CG17469-PA,FlyBase:FBpp0099752,GB_protein:ABC65834.1,REFSEQ:NP_001033808,GB_protein:ABC65834; MD5=ef00b3a47859809f853b0d711e45a3f4; length=730; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=4:join(1219641..1219801,1223420..1223750,1223802..1223921,1223986..1224414,1224988..1225008,1225217..1225376,1225434..1225675,1225732..1225890,1225948..1226517); ID=FBpp0099753; name=Mitf-PB; parent=FBgn0067895,FBtr0100348; dbxref=FlyBase_Annotation_IDs:CG17469-PB,FlyBase:FBpp0099753,GB_protein:ABC65835.1,REFSEQ:NP_001033807,GB_protein:ABC65835; MD5=ef00b3a47859809f853b0d711e45a3f4; length=730; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=4:join(1219641..1219801,1223420..1223750,1223802..1223921,1223986..1224414,1224988..1225008,1225217..1225376,1225434..1225675,1225732..1225890,1225948..1226517); ID=FBpp0099752; name=Mitf-PA; parent=FBgn0067895,FBtr0100347; dbxref=FlyBase_Annotation_IDs:CG17469-PA,FlyBase:FBpp0099752,GB_protein:ABC65834.1,REFSEQ:NP_001033808,GB_protein:ABC65834; MD5=ef00b3a47859809f853b0d711e45a3f4; length=730; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • type=protein; loc=4:join(1219641..1219801,1223420..1223750,1223802..1223921,1223986..1224414,1224988..1225008,1225217..1225376,1225434..1225675,1225732..1225890,1225948..1226517); ID=FBpp0099753; name=Mitf-PB; parent=FBgn0067895,FBtr0100348; dbxref=FlyBase_Annotation_IDs:CG17469-PB,FlyBase:FBpp0099753,GB_protein:ABC65835.1,REFSEQ:NP_001033807,GB_protein:ABC65835; MD5=ef00b3a47859809f853b0d711e45a3f4; length=730; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • MITF OS=Drosophila melanogaster GN=Mitf PE=2 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=4:join(1219641..1219801,1223420..1223750,1223802..1223921,1223986..1224414,1224988..1225008,1225217..1225376,1225434..1225675,1225732..1225890,1225948..1226517); ID=FBpp0298327; name=Mitf-PA; parent=FBgn0263112,FBtr0307326; dbxref=REFSEQ:NP_001033808,GB_protein:ABC65834,FlyBase:FBpp0298327,FlyBase:FBpp0099752,FlyBase_Annotation_IDs:CG17469-PA,FlyBase_Annotation_IDs:CG43369-PA; MD5=ef00b3a47859809f853b0d711e45a3f4; length=730; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=4:join(1219641..1219801,1223420..1223750,1223802..1223921,1223986..1224414,1224988..1225008,1225217..1225376,1225434..1225675,1225732..1225890,1225948..1226517); ID=FBpp0298328; name=Mitf-PB; parent=FBgn0263112,FBtr0307327; dbxref=REFSEQ:NP_001033807,GB_protein:ABC65835,FlyBase:FBpp0298328,FlyBase:FBpp0099753,FlyBase_Annotation_IDs:CG17469-PB,FlyBase_Annotation_IDs:CG43369-PB; MD5=ef00b3a47859809f853b0d711e45a3f4; length=730; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=4:join(1199015..1199175,1219694..1220024,1220076..1220195,1220260..1220688,1221262..1221282,1221491..1221650,1221708..1221949,1222006..1222164,1222222..1222791); ID=FBpp0298327; name=Mitf-PA; parent=FBgn0263112,FBtr0307326; dbxref=REFSEQ:NP_001033808,GB_protein:ABC65834,FlyBase:FBpp0298327,FlyBase:FBpp0099752,FlyBase_Annotation_IDs:CG17469-PA,FlyBase_Annotation_IDs:CG43369-PA; MD5=ef00b3a47859809f853b0d711e45a3f4; length=730; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=4:join(1199015..1199175,1219694..1220024,1220076..1220195,1220260..1220688,1221262..1221282,1221491..1221650,1221708..1221949,1222006..1222164,1222222..1222791); ID=FBpp0298328; name=Mitf-PB; parent=FBgn0263112,FBtr0307327; dbxref=REFSEQ:NP_001033807,GB_protein:ABC65835,FlyBase:FBpp0298328,FlyBase:FBpp0099753,FlyBase_Annotation_IDs:CG17469-PB,FlyBase_Annotation_IDs:CG43369-PB; MD5=ef00b3a47859809f853b0d711e45a3f4; length=730; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=4:join(1199015..1199175,1219694..1220024,1220076..1220195,1220260..1220688,1221262..1221282,1221491..1221650,1221708..1221949,1222006..1222164,1222222..1222791); ID=FBpp0298327; name=Mitf-PA; parent=FBgn0263112,FBtr0307326; dbxref=REFSEQ:NP_001033808,GB_protein:ABC65834,FlyBase:FBpp0298327,FlyBase:FBpp0099752,FlyBase_Annotation_IDs:CG17469-PA,FlyBase_Annotation_IDs:CG43369-PA; MD5=ef00b3a47859809f853b0d711e45a3f4; length=730; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • type=protein; loc=4:join(1199015..1199175,1219694..1220024,1220076..1220195,1220260..1220688,1221262..1221282,1221491..1221650,1221708..1221949,1222006..1222164,1222222..1222791); ID=FBpp0298328; name=Mitf-PB; parent=FBgn0263112,FBtr0307327; dbxref=REFSEQ:NP_001033807,GB_protein:ABC65835,FlyBase:FBpp0298328,FlyBase:FBpp0099753,FlyBase_Annotation_IDs:CG17469-PB,FlyBase_Annotation_IDs:CG43369-PB; MD5=ef00b3a47859809f853b0d711e45a3f4; length=730; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • Isoform of C3KGP2, MITF OS=Drosophila melanogaster GN=Mitf PE=2 SV=1 [DROME.fasta.20160308]
  • FBpp0298327 type=protein; loc=4:join(1199015..1199175,1219694..1220024,1220076..1220195,1220260..1220688,1221262..1221282,1221491..1221650,1221708..1221949,1222006..1222164,1222222..1222791); ID=FBpp0298327; name=Mitf-PA; parent=FBgn0263112,FBtr0307326; dbxref=REFSEQ:NP_001033808,GB_protein:ABC65834,FlyBase:FBpp0298327,FlyBase:FBpp0099752,FlyBase_Annotation_IDs:CG17469-PA,FlyBase_Annotation_IDs:CG43369-PA; MD5=ef00b3a47859809f853b0d711e45a3f4; length=730; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • FBpp0298328 type=protein; loc=4:join(1199015..1199175,1219694..1220024,1220076..1220195,1220260..1220688,1221262..1221282,1221491..1221650,1221708..1221949,1222006..1222164,1222222..1222791); ID=FBpp0298328; name=Mitf-PB; parent=FBgn0263112,FBtr0307327; dbxref=REFSEQ:NP_001033807,GB_protein:ABC65835,FlyBase:FBpp0298328,FlyBase:FBpp0099753,FlyBase_Annotation_IDs:CG17469-PB,FlyBase_Annotation_IDs:CG43369-PB; MD5=ef00b3a47859809f853b0d711e45a3f4; length=730; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=4:join(1199015..1199175,1219694..1220024,1220076..1220195,1220260..1220688,1221262..1221282,1221491..1221650,1221708..1221949,1222006..1222164,1222222..1222791); ID=FBpp0298327; name=Mitf-PA; parent=FBgn0263112,FBtr0307326; dbxref=REFSEQ:NP_001033808,GB_protein:ABC65834,FlyBase:FBpp0298327,FlyBase:FBpp0099752,FlyBase_Annotation_IDs:CG17469-PA,FlyBase_Annotation_IDs:CG43369-PA,UniProt/TrEMBL:Q6WSQ9; MD5=ef00b3a47859809f853b0d711e45a3f4; length=730; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
  • type=protein; loc=4:join(1199015..1199175,1219694..1220024,1220076..1220195,1220260..1220688,1221262..1221282,1221491..1221650,1221708..1221949,1222006..1222164,1222222..1222791); ID=FBpp0298328; name=Mitf-PB; parent=FBgn0263112,FBtr0307327; dbxref=REFSEQ:NP_001033807,GB_protein:ABC65835,FlyBase:FBpp0298328,FlyBase:FBpp0099753,FlyBase_Annotation_IDs:CG17469-PB,FlyBase_Annotation_IDs:CG43369-PB,UniProt/TrEMBL:Q6WSQ9; MD5=ef00b3a47859809f853b0d711e45a3f4; length=730; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 730 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEA]
    Biological Process: compound eye morphogenesis [IMP]
    regulation of transcription [IDA][IEA]
    Molecular Function: transcription regulator activity [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTESGIDLGF DMEFDLNINL LNDNDNMDFL PNVTENMEFY ELKSSSRCIR HNEIPTFKTA  60
   61 TPTSRTQLKL QLQREQQQQM MIQQQTLDTA MDPKMHLLFG SGQGLMESEF IDSGSTSACG 120
  121 SGSSSLEQMS QLVQMDNLID SSSGAKLKVP LQSIGVDVPP QVLQVSTVLE NPTRYHVIQK 180
  181 QKNQVRQYLS ESFKPSMWGS HTSEIKLANN SASTGNLQNS SLQKGICDPL ERTNRFGCDS 240
  241 AVSAKRIMPS DDAMPISPFG GSFVRCDDIN PIEPTVLRPN SHGAGEPENA HRTAQLGLSK 300
  301 ANSSLSSTRS SSGIVNSIRI SSTSSSLQST SAPISPSVSS VATSVSELPS FDSDPDDIFD 360
  361 DILQNDSFNF DKNFNSELSI KQEPQNLTDA EMNALAKDRQ KKDNHNMIER RRRFNINDRI 420
  421 KELGTLLPKG SDAFYEVVRD IRPNKGTILK SSVDYIKCLK HEVTRLRQNE LRQRQVELQN 480
  481 RKLMSRIKEL EMQAKSHGIL LSENHLTSLS APTQPYLKSF SLSPTASRSR RSLFDQPVEK 540
  541 KIQVIDGADG NMGMNQVDEF MEDCKYAVQG GDPMLSSHSH MQSAPQSPSS KTLNSGSFEP 600
  601 KNFSEADESL FRGKSSLASD DCCGINCSTS CYIQHQLTSR EGHPNHSHHT GIREIHSLSD 660
  661 SAQNSEFSRL EHCDDPLLSS SHRSLGTVDE DQHNSVDMSA VMVHDSLSSL VDDNNSETMV 720
  721 LASDTLDIEL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..210] PSI-BLAST 4.045757 Sec24
    2 View Details [211..357] deduced N/A No confident structure predictions are available.
    3 View Details [358..540] PSI-BLAST 9.39794 Solution Structure of Max B-HLH-LZ
    4 View Details [541..730] MSA 5.127993 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • transcription regulator activity
    		•  5.38658950816179 bayes_pls_golite062009
  • DNA binding
    		•  5.18654839258297 bayes_pls_golite062009
  • nucleic acid binding
    		•  5.05768805749761 bayes_pls_golite062009
  • transcription factor activity
    		•  4.78039531631248 bayes_pls_golite062009
  • transcription activator activity
    		•  3.87875547821718 bayes_pls_golite062009
  • binding
    		•  3.81829206350975 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  3.42035985454056 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.39500382187264 bayes_pls_golite062009
  • protein binding
    		•  2.64975291677725 bayes_pls_golite062009
  • transcription factor binding
    		•  2.61163564741984 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity, enhancer binding
    		•  2.42306484786159 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.52770895937238 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.955588849035129 bayes_pls_golite062009
  • promoter binding
    		•  0.8576109846276 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.801830750183111 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.53175615551166 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.3513586903977 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.20674648626116 bayes_pls_golite062009
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle