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Protein Overview: unc-49

General Information:
Name(s) found: unc-49 / CE40337 [WormBase]
Description(s) found:
Found 16 descriptions.
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  • WBGene00006784 locus:unc-49 status:Confirmed UniProt:G5EDM9 protein_id:CAL22699.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 264 amino acids

    Gene Ontology:
    Cellular Component: postsynaptic membrane [IEALink to PubMed article]
    membrane [IEALink to PubMed article]
    integral to membrane [IEALink to PubMed article]
    Biological Process: ion transport [IEALink to PubMed article]
    locomotory behavior [IMPLink to PubMed article]
    regulation of backward locomotion [IMPLink to PubMed article]
    transport [IEALink to PubMed article]
    gamma-aminobutyric acid signaling pathway [IMPLink to PubMed article]
    Molecular Function: neurotransmitter receptor activity [IEALink to PubMed article]
    extracellular ligand-gated ion channel activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MCSDAYSTAE IEYKWCTSKE PNCSTAVKAD ANIELSSYKF TKICQKRTLA STSSGTYSRL  60
   61 RVSFIFDRDS GFYFLQIFFP ASLVVVLSWI SFWINRDSAP SRTLIGTMTV LTETHLMTGT 120
  121 NRRLPPVAYV KAVDVFLGFC YLLVILALIE YACVAYSKKK NEDRRRREKK TEHKPAPPTP 180
  181 DILHDVRLAE CTCNAAPTSI IAVIKQSNRF CVSHSHIDIV SRAAFPLVFI LFNTLFWLIL 240
  241 LYKSKRLPYI SEHEGDRCDA PDLH

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..68] PSI-BLAST 34.69897 Refined structure of the nicotinic acetylcholine receptor at 4A resolution.
    2 View Details [69..264] PSI-BLAST 26.522879 Acetylcholine receptor protein, gamma chain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • transporter activity
    		•  0.8634160537398 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.85769987951557 bayes_pls_golite062009
  • channel activity
    		•  0.82494017759356 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  0.82494017759356 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.699135829541381 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.69403270260693 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.68865958955334 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  0.67623695447613 bayes_pls_golite062009
  • ion channel activity
    		•  0.675765443996379 bayes_pls_golite062009
  • gated channel activity
    		•  0.60374435462213 bayes_pls_golite062009
  • ligand-gated ion channel activity
    		•  0.60262355448371 bayes_pls_golite062009
  • ligand-gated channel activity
    		•  0.60262355448371 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.544647628998121 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  0.537135922480839 bayes_pls_golite062009
  • cation channel activity
    		•  0.53391585932077 bayes_pls_golite062009
  • excitatory extracellular ligand-gated ion channel activity
    		•  0.463355765957441 bayes_pls_golite062009
  • extracellular ligand-gated ion channel activity
    		•  0.463355765957441 bayes_pls_golite062009
  • nicotinic acetylcholine-activated cation-selective channel activity
    		•  0.26375810963714 bayes_pls_golite062009
  • binding
    		•  0.227765742225932 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
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