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View Structure Prediction Details

Protein: unc-49
Organism: Caenorhabditis elegans
Length: 264 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for unc-49.

Description E-value Query
Range
Subject
Range
gi|39591873, gi|... - gi|39591873|emb|CAE71451.1| Hypothetical protein CBG18364 [Caenorhabditis briggsae], gi|187025367|em...
gi|157775779 - gi|157775779|ref|XP_001665955.1| hypothetical protein CBG18364 [Caenorhabditis briggsae AF16]
210.0 [0..1] [264..185]

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Predicted Domain #1
Region A:
Residues: [1-68]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MCSDAYSTAE IEYKWCTSKE PNCSTAVKAD ANIELSSYKF TKICQKRTLA STSSGTYSRL  60
   61 RVSFIFDR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 34.69897
Match: 2bg9A
Description: Refined structure of the nicotinic acetylcholine receptor at 4A resolution.
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [69-264]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DSGFYFLQIF FPASLVVVLS WISFWINRDS APSRTLIGTM TVLTETHLMT GTNRRLPPVA  60
   61 YVKAVDVFLG FCYLLVILAL IEYACVAYSK KKNEDRRRRE KKTEHKPAPP TPDILHDVRL 120
  121 AECTCNAAPT SIIAVIKQSN RFCVSHSHID IVSRAAFPLV FILFNTLFWL ILLYKSKRLP 180
  181 YISEHEGDRC DAPDLH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 26.522879
Match: 1oedE
Description: Acetylcholine receptor protein, gamma chain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transporter activity 0.8634160537398 bayes_pls_golite062009
transmembrane transporter activity 0.85769987951557 bayes_pls_golite062009
channel activity 0.82494017759356 bayes_pls_golite062009
passive transmembrane transporter activity 0.82494017759356 bayes_pls_golite062009
substrate-specific transporter activity 0.699135829541381 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.69403270260693 bayes_pls_golite062009
ion transmembrane transporter activity 0.68865958955334 bayes_pls_golite062009
substrate-specific channel activity 0.67623695447613 bayes_pls_golite062009
ion channel activity 0.675765443996379 bayes_pls_golite062009
gated channel activity 0.60374435462213 bayes_pls_golite062009
ligand-gated ion channel activity 0.60262355448371 bayes_pls_golite062009
ligand-gated channel activity 0.60262355448371 bayes_pls_golite062009
cation transmembrane transporter activity 0.544647628998121 bayes_pls_golite062009
metal ion transmembrane transporter activity 0.537135922480839 bayes_pls_golite062009
cation channel activity 0.53391585932077 bayes_pls_golite062009
excitatory extracellular ligand-gated ion channel activity 0.463355765957441 bayes_pls_golite062009
extracellular ligand-gated ion channel activity 0.463355765957441 bayes_pls_golite062009
nicotinic acetylcholine-activated cation-selective channel activity 0.26375810963714 bayes_pls_golite062009
binding 0.227765742225932 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle