Protein Overview: CFTR_RAT

General Information:
Name(s) found:	CFTR_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|91982740\|ref\|NP_113694.1\| cystic fibrosis transmembrane conductance regulator [Rattus norvegicus] [NCBI NR] gi\|38322765\|gb\|AAR16315.1\| cystic fibrosis transmembrane conductance regulator, ATP-binding cassette (sub-family C, member 7) [Rattus norvegicus] [NCBI NR] gi\|149065051\|gb\|EDM15127.1\| rCG28062 [Rattus norvegicus] [NCBI NR] gi\|148887355\|sp\|P34158.3\|CFTR_RAT RecName: Full=Cystic fibrosis transmembrane conductance regulator; Short=CFTR; AltName: Full=Channel conductance-controlling ATPase; AltName: Full=cAMP-dependent chloride channel; AltName: Full=ATP-binding cassette transp [NCBI NR] Cystic fibrosis transmembrane conductance regulator OS=Rattus norvegicus GN=Cftr PE=1 SV=3 [Swiss-Prot] cystic fibrosis transmembrane conductance regulator, ATP-binding cassette (sub-family C, member 7) [Rattus norvegicus] [nrdb_11152004_Chlamydomonas] cystic fibrosis transmembrane conductance regulator [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Cystic fibrosis transmembrane conductance regulator (CFTR) (cAMP-dependent chloride channel) (ATP-binding cassette transporter sub-family C member 7) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] rCG28062 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] cystic fibrosis transmembrane conductance regulator homolog [Rattus norvegicus] [nr-271106-contam.fasta] Tax_Id=10116 Gene_Symbol=Cftr Cystic fibrosis transmembrane conductance regulator [rat-ipi-250309-contam.fasta] Cystic fibrosis transmembrane conductance regulator OS=Rattus norvegicus GN=Cftr [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	1476 amino acids
Gene Ontology:
Cellular Component:	chloride channel complex [IEA] early endosome [UNKNOWN][ISS] cytoplasmic vesicle membrane [IDA] cytoplasm [IDA] microvillus [IDA] membrane [IEA] integral to membrane [IEA] basolateral plasma membrane [IDA] endoplasmic reticulum Sec complex [UNKNOWN][IEA] apical plasma membrane [UNKNOWN][IDA]
Biological Process:	response to cytokine stimulus [IEP] response to estrogen stimulus [IEP] transmembrane transport [IEA] positive regulation of vasodilation [IDA] cholesterol biosynthetic process [UNKNOWN][IEA] vasodilation [IMP] chloride transport [IMP] response to peptide hormone stimulus [IEP] body fluid secretion [TAS] ion transport [IEA] water transport [IMP] response to drug [IEP] iodide transport [IMP] transepithelial chloride transport [IMP] cellular response to hormone stimulus [IEP] cholesterol transport [UNKNOWN][IEA] bicarbonate transport [IMP] lung development [IMP]
Molecular Function:	nucleotide binding [IEA] ATPase activity [IEA] ion channel activity [IEA] ATP binding [IEA] protein binding [UNKNOWN][IEA] channel-conductance-controlling ATPase activity [IEA] PDZ domain binding [UNKNOWN][IEA] molecular_function [ND] hydrolase activity [IEA] enzyme binding [UNKNOWN]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQKSPLEKAS FISKLFFSWT TPILRKGYRH HLELSDIYQA PSSDSADHLS EKLEREWDRE  60
   61 QASKKKPQLI HALRRCFVWR FVFYGVLLYL GEVTKAVQPV LLGRIIASYD PDNTEERSIA 120
  121 IYLGIGLCLL FIVRTLLLHP AIFGLHHIGM QMRIAMFSLI YKKTLKLSSR VLDKISIGQL 180
  181 ISLLSNNLNK FDEGLALAHF IWIAPLQVVL LMGLLWDLLQ FSAFCGLGLL IVLVIFQAIL 240
  241 GKMMVKYRDK RAAKINERLV ITSEVIDNIY SVKAYCWESA MEKIIESLRE EELKMTRRSA 300
  301 YMRFFTSSAF FFSGFFVVFL SVLPYTVING IVLRKIFTTI SFCIVLRMSV TRQFPTAVQI 360
  361 WYDSLGMIRK IQDFLQTQEY KVLEYNLMFT GLVMENVTAF WEEGFQELLE KVQLNNDDRK 420
  421 TSNGENHLSF SHLCLVGNPV LKNINLNIKK GEMLAITGST GAGKTSLLML ILGELEASEG 480
  481 IIKHSGRVSF SSQISWIMPG TIKENIIFGV SYDEYRYKSV VKACQLQEDI TKFAEQDNTV 540
  541 LGEGGVTLSG GQRARISLAR AVYKDADLYL LDSPFGYLDV LTEEQIFESC VCKLMASKTR 600
  601 ILVTSKMEQL KKADKILILH EGSSYFYGTF SELQSLRPDF SSKLMGYDTF DQFTEERRSS 660
  661 ILTETLRRFS VDDASTTWNK AKQSFRQTGE FGEKRKNSIL SSFSSVKKIS IVQKTPLSIE 720
  721 GESDDLQERR LSLVPDSEHG EAALPRSNMI TAGPTFPGRR RQSVLDLMTF TPSSVSSSLQ 780
  781 RTRASIRKIS LAPRISLKEE DIYSRRLSQD STLNITEEIN EEDLKECFFD DMVKIPTVTT 840
  841 WNTYLRYFTL HRGLFAVLIW CVLVFLVEVA ASLFVLWLLK NNPVNGGNNG TKIANTSYVV 900
  901 VITSSSFYYI FYIYVGVADT LLALSLFRGL PLVHTLITAS KILHRKMLHS ILHAPMSTFN 960
  961 KLKAGGILNR FSKDIAILDD FLPLTIFDFI QLLFIVVGAI IVVSALQPYI FLATVPGLAV1020
 1021 FILLRAYFLH TSQQLKQLES EGRSPIFTHL VTSLKGLWTL RAFRRQTYFE TLFHKALNLH1080
 1081 TANWFMYLAT LRWFQMRIDM IFVLFFIVVT FISILTTGEG EGTTGIILTL AMNIMSTLQW1140
 1141 AVNSSIDTDS LMRSVSRVFK FIDIQTEESI CTKIMKELHS EDSPNALVIK NEHVKKCDTW1200
 1201 PSGGEMVVKD LTVKYVDDGN AILENISFSI SPGQRVGLLG RTGSGKSTLL SAFLRMLNIK1260
 1261 GEIQIDGVSW NSMTLQEWRK AFGVITQKVF IFSGTFRQNL DPNGKWRDEE IWKVADQVGL1320
 1321 KSVIEQFPGQ LNFTLVDGGY VLSHGHKQLM CLARSVLSKA KIILLDEPSA NLDPITYQVI1380
 1381 RRVLRQAFAG CTVVLCEHRI EAMLDCQRFL VIEQGNVWQY ESLQALLSEK SVFQRALSSS1440
 1441 EKMKLFHGRH SSKQKPRTQI TAVKEETEEE VQETRL

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: CFTR_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: