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Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate. An animal enzyme that is active in forming a chloride channel, the absence of which brings about cystic fibrosis. It is also involved in the functioning of other transmembrane channels. Primary active transport of a solute across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source. Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. Catalysis of facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. Catalysis of the energy-independent passage of anions across a lipid bilayer down a concentration gradient. Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the transport of a substance.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: channel-conductance-controlling ATPase activity
Acc: GO:0005260
Aspect: Molecular Function
Desc: Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate. An animal enzyme that is active in forming a chloride channel, the absence of which brings about cystic fibrosis. It is also involved in the functioning of other transmembrane channels.
Synonyms:
  • cystic-fibrosis membrane-conductance-regulating protein activity
  • cystic fibrosis transmembrane conductance regulator
  • ATP phosphohydrolase (channel-conductance-controlling)
Proteins in PDR annotated with:
   This term: 2 [Search]
   Term or descendants: 2 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0005260 - channel-conductance-controlling ATPase activity (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle