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Protein Overview: nhr-66

General Information:
Name(s) found: nhr-66 / CE37723 [WormBase]
Description(s) found:
Found 14 descriptions.
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  • WBGene00003656 locus:nhr-66 status:Partially_confirmed UniProt:Q5W611 protein_id:CCD63565.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 659 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEALink to PubMed article]
    Biological Process: nematode larval development [IMPLink to PubMed article]
    positive regulation of growth rate [IMPLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed article]
    regulation of transcription, DNA-dependent [IEALink to PubMed article]
    Molecular Function: DNA binding [IEALink to PubMed article]
    transcription factor activity [IEALink to PubMed article]
    zinc ion binding [IEALink to PubMed article]
    steroid hormone receptor activity [IEALink to PubMed article]
    sequence-specific DNA binding [IEALink to PubMed article]
    steroid binding [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTPQIGLTGL GSLTSLPPEL LLQFARLDGF NLLPAVGSPA IPSSSSCSEP STSQASTVVS  60
   61 APTLPPPSPL TSLPQKPAPL MPSGHVTTVD QQNRQQHQQQ QRQQQQAQQQ NSMARKYSMD 120
  121 TIQHHTMQHP HQLQYIPNHF MTASTDVFAA MDMSQKQSSP PGIFKIVAAK NEPSSSSNSQ 180
  181 PGTPAMGDRR AVPACAICGT DSTGIHFGVD ACAACSAFFR RTVVLNKDYS CNKGGKCTVV 240
  241 KDGSAGQKCR ACRFRKCISS GMDKNSVQHR RDAIGKYSAG VKRELSPDAE FEPSAKVSTV 300
  301 SEPSTSSGPS GGFNQNVSSP AGIPRVPSTL RTTQASTCMN SACGQKSVLH ELICRQNFLT 360
  361 EQRQLFYAGC LGDWFRKPSS IENQTLSELT DFSSCMFHLW KIEPRLAADF MNRNRYLDPL 420
  421 PIVEKLKIYR NFVIMRQSVE EPYLTWRHGG LEKRWFVMPN NTYIDFNNIA KYFENGALKD 480
  481 LKLDYETTTN LFLPSFTHAM DTIGEKMKKN NITETELTIL LGLVLLDPGI YGIHESTRKF 540
  541 LKRIRDQLIH DVYMYYEDEM SHLYDPEIRM ADIFMLVAAI KIHSIKTSEN MHMLRVFDLI 600
  601 PADACFNQML DVESVNVSPD GQKDSEAEQG PSPVSVPEAA RGSYQDDDMP PVLEKNCDL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..187] MSA 11.323997 View MSA. No confident structure predictions are available.
    2 View Details [188..317] PSI-BLAST 27.0 Human Liver Receptor Homologue DNA-Binding Domain (hLRH-1 DBD) in Complex with dsDNA from the hCYP7A1 Promoter
    3 View Details [318..659] PSI-BLAST 45.522879 Crystal Structure of the RARbeta/RXRalpha Ligand Binding Domain Heterodimer in Complex with 9-cis Retinoic Acid and a Fragment of the TRAP220 Coactivator

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • binding
    		•  2.31508164334985 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.02157665604796 bayes_pls_golite062009
  • DNA binding
    		•  1.47175550190876 bayes_pls_golite062009
  • signal transducer activity
    		•  1.430912689846 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.430912689846 bayes_pls_golite062009
  • protein binding
    		•  1.34648900580465 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.29377568150934 bayes_pls_golite062009
  • receptor activity
    		•  1.17902442273252 bayes_pls_golite062009
  • ligand-dependent nuclear receptor activity
    		•  1.16718542519809 bayes_pls_golite062009
  • transcription activator activity
    		•  0.96843436755116 bayes_pls_golite062009
  • transcription factor activity
    		•  0.92060883178562 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.67007540744134 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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