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Protein Overview: SIN3_YEAST

General Information:
Name(s) found: SIN3_YEAST [Swiss-Prot]
Description(s) found:
  • Transcriptional regulatory protein SIN3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SIN3 PE=1 SV=2 [Swiss-Prot]
    • Organism: Saccharomyces cerevisiae S288c
    Length: 1536 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQVWHNSNS QSNDVATSND ATGSNERNEK EPSLQGNKPG FVQQQQRITL PSLSALSTKE  60
   61 EDRRDSNGQQ ALTSHAAHIL GYPPPHSNAM PSIATDSALK QPHEYHPRPK SSSSSPSINA 120
  121 SLMNAGPAPL PTVGAASFSL SRFDNPLPIK APVHTEEPKS YNGLQEEEKA TQRPQDCKEV 180
  181 PAGVQPADAP DPSSNHADAN DDNNNNENSH DEDADYRPLN VKDALSYLEQ VKFQFSSRPD 240
  241 IYNLFLDIMK DFKSQAIDTP GVIERVSTLF RGYPILIQGF NTFLPQGYRI ECSSNPDDPI 300
  301 RVTTPMGTTT VNNNISPSGR GTTDAQELGS FPESDGNGVQ QPSNVPMVPS SVYQSEQNQD 360
  361 QQQSLPLLAT SSGLPSIQQP EMPAHRQIPQ SQSLVPQEDA KKNVDVEFSQ AISYVNKIKT 420
  421 RFADQPDIYK HFLEILQTYQ REQKPINEVY AQVTHLFQNA PDLLEDFKKF LPDSSASANQ 480
  481 QVQHAQQHAQ QQHEAQMHAQ AQAQAQAQAQ VEQQKQQQQF LYPASGYYGH PSNRGIPQQN 540
  541 LPPIGSFSPP TNGSTVHEAY QDQQHMQPPH FMPLPSIVQH GPNMVHQGIA NENPPLSDLR 600
  601 TSLTEQYAPS SIQHQQQHPQ SISPIANTQY GDIPVRPEID LDPSIVPVVP EPTEPIENNI 660
  661 SLNEEVTFFE KAKRYIGNKH LYTEFLKILN LYSQDILDLD DLVEKVDFYL GSNKELFTWF 720
  721 KNFVGYQEKT KCIENIVHEK HRLDLDLCEA FGPSYKRLPK SDTFMPCSGR DDMCWEVLND 780
  781 EWVGHPVWAS EDSGFIAHRK NQYEETLFKI EEERHEYDFY IESNLRTIQC LETIVNKIEN 840
  841 MTENEKANFK LPPGLGHTSM TIYKKVIRKV YDKERGFEII DALHEHPAVT APVVLKRLKQ 900
  901 KDEEWRRAQR EWNKVWRELE QKVFFKSLDH LGLTFKQADK KLLTTKQLIS EISSIKVDQT 960
  961 NKKIHWLTPK PKSQLDFDFP DKNIFYDILC LADTFITHTT AYSNPDKERL KDLLKYFISL1020
 1021 FFSISFEKIE ESLYSHKQNV SESSGSDDGS SIASRKRPYQ QEMSLLDILH RSRYQKLKRS1080
 1081 NDEDGKVPQL SEPPEEEPNT IEEEELIDEE AKNPWLTGNL VEEANSQGII QNRSIFNLFA1140
 1141 NTNIYIFFRH WTTIYERLLE IKQMNERVTK EINTRSTVTF AKDLDLLSSQ LSEMGLDFVG1200
 1201 EDAYKQVLRL SRRLINGDLE HQWFEESLRQ AYNNKAFKLY TIDKVTQSLV KHAHTLMTDA1260
 1261 KTAEIMALFV KDRNASTTSA KDQIIYRLQV RSHMSNTENM FRIEFDKRTL HVSIQYIALD1320
 1321 DLTLKEPKAD EDKWKYYVTS YALPHPTEGI PHEKLKIPFL ERLIEFGQDI DGTEVDEEFS1380
 1381 PEGISVSTLK IKIQPITYQL HIENGSYDVF TRKATNKYPT IANDNTQKGM VSQKKELISK1440
 1441 FLDCAVGLRN NLDEAQKLSM QKKWENLKDS IAKTSAGNQG IESETEKGKI TKQEQSDNLD1500
 1501 SSTASVLPAS ITTVPQDDNI ETTGNTESSD KGAKIQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..237] ORFEUS 11.5 RBP1
    2 View Details [238..321] Pfam 19.346787 Paired amphipathic helix repeat No confident structure predictions are available.
    3 View Details [322..423] deduced N/A No confident structure predictions are available.
    4 View Details [424..489] Pfam 19.69897 Paired amphipathic helix repeat No confident structure predictions are available.
    5 View Details [490..606] PSI-BLAST 172.134302 Sin3A
    6 View Details [607..732] ORFEUS 11.33 Sin3A
    7 View Details [733..1024] MSA 1.021966 View MSA. No confident structure predictions are available.
    8 View Details [1025..1368] MSA 2.019929 View MSA. No confident structure predictions are available.
    9 View Details [1369..1536] MSA 2.014993 View MSA. No confident structure predictions are available.
    10 View Details [1179..1355] deduced N/A No confident structure predictions are available.
    11 View Details [1356..1449] deduced N/A No confident structure predictions are available.
    12 View Details [1450..1536] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • protein deacetylase activity
    		•  8.92489148049718 bayes_pls_golite062009
  • histone deacetylase activity
    		•  8.77562367748348 bayes_pls_golite062009
  • deacetylase activity
    		•  7.74805102638387 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
    		•  5.99241841178307 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
    		•  4.85992273034906 bayes_pls_golite062009
  • transcription repressor activity
    		•  4.25514230798992 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.82193713323077 bayes_pls_golite062009
  • transcription corepressor activity
    		•  3.30769773581294 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.83214064778422 bayes_pls_golite062009
  • DNA binding
    		•  2.82083682611814 bayes_pls_golite062009
  • transcription factor binding
    		•  2.73494763175272 bayes_pls_golite062009
  • transcription cofactor activity
    		•  2.59356984380124 bayes_pls_golite062009
  • binding
    		•  2.59005615358803 bayes_pls_golite062009
  • protein binding
    		•  2.41769888237582 bayes_pls_golite062009
  • transcription factor activity
    		•  1.99794029160509 bayes_pls_golite062009
  • transcription activator activity
    		•  1.89949115818087 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.41949477529902 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.918453145717461 bayes_pls_golite062009
  • catalytic activity
    		•  0.30211814650972 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • protein deacetylase activity
    		•  9.15317765173842 bayes_pls_golite062009
  • histone deacetylase activity
    		•  9.00540919224423 bayes_pls_golite062009
  • deacetylase activity
    		•  7.91874136549804 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
    		•  6.08470985892139 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
    		•  4.91057345050982 bayes_pls_golite062009
  • transcription repressor activity
    		•  4.58162229232685 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.97924147512738 bayes_pls_golite062009
  • transcription corepressor activity
    		•  3.71696410617503 bayes_pls_golite062009
  • transcription factor binding
    		•  3.06004981994503 bayes_pls_golite062009
  • transcription cofactor activity
    		•  2.96293930027313 bayes_pls_golite062009
  • DNA binding
    		•  2.90699688513784 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.89854237920034 bayes_pls_golite062009
  • binding
    		•  2.65480555250736 bayes_pls_golite062009
  • protein binding
    		•  2.51615225301602 bayes_pls_golite062009
  • transcription factor activity
    		•  2.07660852403223 bayes_pls_golite062009
  • transcription activator activity
    		•  1.96507140095887 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.50631346254518 bayes_pls_golite062009
  • transcription coactivator activity
    		•  1.06494495723884 bayes_pls_golite062009
  • catalytic activity
    		•  0.289349813503192 bayes_pls_golite062009
    6
    Term Confidence Notes
  • protein deacetylase activity
    		•  8.92489148049718 bayes_pls_golite062009
  • histone deacetylase activity
    		•  8.77562367748348 bayes_pls_golite062009
  • deacetylase activity
    		•  7.74805102638387 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
    		•  5.99241841178307 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
    		•  4.85992273034906 bayes_pls_golite062009
  • transcription repressor activity
    		•  4.25514230798992 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.82193713323077 bayes_pls_golite062009
  • transcription corepressor activity
    		•  3.30769773581294 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.83214064778422 bayes_pls_golite062009
  • DNA binding
    		•  2.82083682611814 bayes_pls_golite062009
  • transcription factor binding
    		•  2.73494763175272 bayes_pls_golite062009
  • transcription cofactor activity
    		•  2.59356984380124 bayes_pls_golite062009
  • binding
    		•  2.59005615358803 bayes_pls_golite062009
  • protein binding
    		•  2.41769888237582 bayes_pls_golite062009
  • transcription factor activity
    		•  1.99794029160509 bayes_pls_golite062009
  • transcription activator activity
    		•  1.89949115818087 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.41949477529902 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.918453145717461 bayes_pls_golite062009
  • catalytic activity
    		•  0.30211814650972 bayes_pls_golite062009
    7 No functions predicted.
    8 No functions predicted.
    9 No functions predicted.
    10 No functions predicted.
    11 No functions predicted.
    12 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle