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Protein Overview: HST4_YEAST

General Information:
Name(s) found: HST4_YEAST [Swiss-Prot]
Description(s) found:
  • NAD-dependent histone deacetylase HST4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HST4 PE=1 SV=1 [Swiss-Prot]
    • Organism: Saccharomyces cerevisiae S288c
    Length: 370 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKQKFVLPIT PPSTAEKKPQ TENRCNENLK PRRLLPQLKK SVRNRKPRLS YRPELNSVFD  60
   61 LDAYVDSTHL SKSQRHHMDR DAGFISYALN YSKRMVVVSG AGISVAAGIP DFRSSEGIFS 120
  121 TVNGGSGKDL FDYNRVYGDE SMSLKFNQLM VSLFRLSKNC QPTKFHEMLN EFARDGRLLR 180
  181 LYTQNIDGLD TQLPHLSTNV PLAKPIPSTV QLHGSIKHME CNKCLNIKPF DPELFKCDDK 240
  241 FDSRTEIIPS CPQCEEYETV RKMAGLRSTG VGKLRPRVIL YNEVHPEGDF IGEIANNDLK 300
  301 KRIDCLIIVG TSLKIPGVKN ICRQFAAKVH ANRGIVLYLN TSMPPKNVLD SLKFVDLVVL 360
  361 GDCQHVTSLL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..112]
    [157..215]
    [285..370]    		 PSI-BLAST 143.035458 AF1676, Sir2 homolog (Sir2-AF1?)
    2 View Details [113..156]
    [216..284]    		 PSI-BLAST 143.035458 AF1676, Sir2 homolog (Sir2-AF1?)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein deacetylase activity
    		•  7.35763207610992 bayes_pls_golite062009
  • histone deacetylase activity
    		•  7.26335959347303 bayes_pls_golite062009
  • NAD-dependent protein deacetylase activity
    		•  6.47581529902049 bayes_pls_golite062009
  • NAD-dependent histone deacetylase activity
    		•  6.47581529902049 bayes_pls_golite062009
  • deacetylase activity
    		•  6.37006322346047 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
    		•  3.69142507295713 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.9155913558118 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
    		•  2.82468859281133 bayes_pls_golite062009
  • DNA binding
    		•  2.43141001866996 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.41433477472968 bayes_pls_golite062009
  • transcription repressor activity
    		•  2.24657784428979 bayes_pls_golite062009
  • binding
    		•  2.06552694538163 bayes_pls_golite062009
  • histone binding
    		•  1.71445510915336 bayes_pls_golite062009
  • transcription corepressor activity
    		•  1.64212790017753 bayes_pls_golite062009
  • transcription factor activity
    		•  1.30143289828088 bayes_pls_golite062009
  • transcription factor binding
    		•  1.14766678956419 bayes_pls_golite062009
  • catalytic activity
    		•  0.739210399081789 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.54005617175343 bayes_pls_golite062009
  • NAD-dependent histone deacetylase activity (H4-K16 specific)
    		•  0.524001879800456 bayes_pls_golite062009
  • protein binding
    		•  0.475479132768057 bayes_pls_golite062009
  • tubulin deacetylase activity
    		•  0.191267552550115 bayes_pls_golite062009
  • NAD+ ADP-ribosyltransferase activity
    		•  0.0099486881187274 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.59

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle