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Protein Overview: ACS2_YEAST

General Information:
Name(s) found: ACS2_YEAST [Swiss-Prot]
Description(s) found:
  • Acetyl-coenzyme A synthetase 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ACS2 PE=1 SV=1 [Swiss-Prot]
    • Organism: Saccharomyces cerevisiae S288c
    Length: 683 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTIKEHKVVY EAHNVKALKA PQHFYNSQPG KGYVTDMQHY QEMYQQSINE PEKFFDKMAK  60
   61 EYLHWDAPYT KVQSGSLNNG DVAWFLNGKL NASYNCVDRH AFANPDKPAL IYEADDESDN 120
  121 KIITFGELLR KVSQIAGVLK SWGVKKGDTV AIYLPMIPEA VIAMLAVARI GAIHSVVFAG 180
  181 FSAGSLKDRV VDANSKVVIT CDEGKRGGKT INTKKIVDEG LNGVDLVSRI LVFQRTGTEG 240
  241 IPMKAGRDYW WHEEAAKQRT YLPPVSCDAE DPLFLLYTSG STGSPKGVVH TTGGYLLGAA 300
  301 LTTRYVFDIH PEDVLFTAGD VGWITGHTYA LYGPLTLGTA SIIFESTPAY PDYGRYWRII 360
  361 QRHKATHFYV APTALRLIKR VGEAEIAKYD TSSLRVLGSV GEPISPDLWE WYHEKVGNKN 420
  421 CVICDTMWQT ESGSHLIAPL AGAVPTKPGS ATVPFFGINA CIIDPVTGVE LEGNDVEGVL 480
  481 AVKSPWPSMA RSVWNHHDRY MDTYLKPYPG HYFTGDGAGR DHDGYYWIRG RVDDVVNVSG 540
  541 HRLSTSEIEA SISNHENVSE AAVVGIPDEL TGQTVVAYVS LKDGYLQNNA TEGDAEHITP 600
  601 DNLRRELILQ VRGEIGPFAS PKTIILVRDL PRTRSGKIMR RVLRKVASNE AEQLGDLTTL 660
  661 ANPEVVPAII SAVENQFFSQ KKK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..79]
    [345..531]    		 PSI-BLAST 269.218487 Phenylalanine activating domain of gramicidin synthetase 1
    2 View Details [80..127]
    [280..344]
    [532..683]    		 PSI-BLAST 269.218487 Phenylalanine activating domain of gramicidin synthetase 1
    3 View Details [128..279] PSI-BLAST 269.218487 Phenylalanine activating domain of gramicidin synthetase 1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ligase activity, forming carbon-sulfur bonds
    		•  5.10123876514454 bayes_pls_golite062009
  • fatty acid ligase activity
    		•  4.83067429373059 bayes_pls_golite062009
  • long-chain fatty acid-CoA ligase activity
    		•  4.72692389032116 bayes_pls_golite062009
  • acetate-CoA ligase activity
    		•  4.48129067128523 bayes_pls_golite062009
  • acid-thiol ligase activity
    		•  4.28278725989432 bayes_pls_golite062009
  • CoA-ligase activity
    		•  4.12850865352867 bayes_pls_golite062009
  • Photinus-luciferin 4-monooxygenase (ATP-hydrolyzing) activity
    		•  2.74744781333102 bayes_pls_golite062009
  • oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)
    		•  2.74744781333102 bayes_pls_golite062009
  • luciferin monooxygenase activity
    		•  2.67396462766343 bayes_pls_golite062009
  • ligase activity
    		•  2.49556073715112 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.31193176808353 bayes_pls_golite062009
  • catalytic activity
    		•  1.83545185797733 bayes_pls_golite062009
  • binding
    		•  1.5312519256537 bayes_pls_golite062009
  • transporter activity
    		•  1.29780964436121 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.2638869228049 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.07143339827205 bayes_pls_golite062009
  • acetoacetate-CoA ligase activity
    		•  1.03788694975627 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.03753946113449 bayes_pls_golite062009
  • protein binding
    		•  0.985225190358794 bayes_pls_golite062009
  • AMP binding
    		•  0.778227294974491 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.54797726647835 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.519946577969422 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.500908589473269 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  0.464663038956639 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.398310577427897 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.251681382273558 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  0.225448500718996 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  0.216579620878492 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  0.177812048124158 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  0.174283007890308 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  0.173963339749644 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0401881910649647 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.0047964784091391 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.73

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle