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Protein Overview: POLH_YEAST

General Information:
Name(s) found: POLH_YEAST [Swiss-Prot]
Description(s) found:
Found 2 descriptions.
SHOW ALL
  • DNA polymerase eta OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RAD30 PE=1 SV=1 [Swiss-Prot]
    • Organism: Saccharomyces cerevisiae S288c
    Length: 632 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKFTWKELI QLGSPSKAYE SSLACIAHID MNAFFAQVEQ MRCGLSKEDP VVCVQWNSII  60
   61 AVSYAARKYG ISRMDTIQEA LKKCSNLIPI HTAVFKKGED FWQYHDGCGS WVQDPAKQIS 120
  121 VEDHKVSLEP YRRESRKALK IFKSACDLVE RASIDEVFLD LGRICFNMLM FDNEYELTGD 180
  181 LKLKDALSNI REAFIGGNYD INSHLPLIPE KIKSLKFEGD VFNPEGRDLI TDWDDVILAL 240
  241 GSQVCKGIRD SIKDILGYTT SCGLSSTKNV CKLASNYKKP DAQTIVKNDC LLDFLDCGKF 300
  301 EITSFWTLGG VLGKELIDVL DLPHENSIKH IRETWPDNAG QLKEFLDAKV KQSDYDRSTS 360
  361 NIDPLKTADL AEKLFKLSRG RYGLPLSSRP VVKSMMSNKN LRGKSCNSIV DCISWLEVFC 420
  421 AELTSRIQDL EQEYNKIVIP RTVSISLKTK SYEVYRKSGP VAYKGINFQS HELLKVGIKF 480
  481 VTDLDIKGKN KSYYPLTKLS MTITNFDIID LQKTVVDMFG NQVHTFKSSA GKEDEEKTTS 540
  541 SKADEKTPKL ECCKYQVTFT DQKALQEHAD YHLALKLSEG LNGAEESSKN LSFGEKRLLF 600
  601 SRKRPNSQHT ATPQKKQVTS SKNILSFFTR KK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..33]
    [122..299]    		 PSI-BLAST 10119.0 DNA polymerase eta
    2 View Details [34..121]
    [300..388]    		 PSI-BLAST 10119.0 DNA polymerase eta
    3 View Details [389..530] PSI-BLAST 10119.0 DNA polymerase eta
    4 View Details [531..632] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • DNA-directed DNA polymerase activity
    		•  8.5725258398851 bayes_pls_golite062009
  • DNA polymerase activity
    		•  8.52309706572764 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  6.34496739872612 bayes_pls_golite062009
  • DNA primase activity
    		•  5.34779288251618 bayes_pls_golite062009
  • chromatin binding
    		•  2.18085270555452 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.74380808085854 bayes_pls_golite062009
  • DNA binding
    		•  1.69096430884207 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.57540655259696 bayes_pls_golite062009
  • binding
    		•  1.40175931463327 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.06010018021303 bayes_pls_golite062009
  • catalytic activity
    		•  1.04899053677564 bayes_pls_golite062009
  • DNA-directed RNA polymerase activity
    		•  0.83818211151495 bayes_pls_golite062009
  • RNA polymerase activity
    		•  0.83818211151495 bayes_pls_golite062009
  • transferase activity
    		•  0.784455099927681 bayes_pls_golite062009
  • exonuclease activity
    		•  0.778608024896469 bayes_pls_golite062009
  • damaged DNA binding
    		•  0.39441061793492 bayes_pls_golite062009
  • protein binding
    		•  0.354190470641287 bayes_pls_golite062009
  • 3'-5' exonuclease activity
    		•  0.0700154911930899 bayes_pls_golite062009
    2
    Term Confidence Notes
  • transcription regulator activity
    		•  3.3375695352073 bayes_pls_golite062009
  • DNA binding
    		•  3.28852346568913 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.28464324017293 bayes_pls_golite062009
  • binding
    		•  2.56809202445862 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  2.42858975345257 bayes_pls_golite062009
  • transcription factor activity
    		•  2.32991522163341 bayes_pls_golite062009
  • chromatin binding
    		•  2.32872787634324 bayes_pls_golite062009
  • transcription activator activity
    		•  1.20800295439208 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.14039305317011 bayes_pls_golite062009
  • protein binding
    		•  0.952480850696098 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.752135837564561 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.733541244206639 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.564341752288536 bayes_pls_golite062009
  • transcription factor binding
    		•  0.547857728784058 bayes_pls_golite062009
  • catalytic activity
    		•  0.263007611601737 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle