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Protein Overview: WNK2_ARATH

General Information:
Name(s) found: WNK2_ARATH [Swiss-Prot]
Description(s) found:
Found 14 descriptions.
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  • Serine/threonine-protein kinase WNK2 OS=Arabidopsis thaliana GN=WNK2 PE=1 SV=1 [Swiss-Prot]
    • Organism: Arabidopsis thaliana
    Length: 568 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: photoperiodism, flowering [IMP]
    protein amino acid phosphorylation [TAS]
    Molecular Function: protein kinase activity [TAS]
    kinase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNGEESFVED CSVFVEIDPS GRYGRYDEIL GKGASKTVYR AFDEYEGIEV AWNQVKLRNF  60
   61 TRNPEELEKF FREIHLLKTL NHQNIMKFYT SWVDTNNLSI NFVTELFTSG TLRQYRLRHR 120
  121 RVNIRAVKQW CKQILKGLLY LHSRSPPIIH RDLKCDNIFI NGNQGEVKIG DLGLAAILRK 180
  181 SHAVRCVGTP EFMAPEVYDE EYNELVDVYA FGMCVLEMVT FDYPYSECTH PAQIYKKVTS 240
  241 GKKPEAFYLV KDPEVREFVE KCLANVTCRL TALELLQDPF LQDDNMDGFV MRPIDYYNGY 300
  301 DETGVFLRHP LIDDPLYHDQ FESSQICEID LFANDDEDHV DISIKGKRNG DDGIFLRLRI 360
  361 SDAEGRIRNI YFPFETAIDT AWSVAVEMVS ELDITNQDVA KIAEMIDAEI AALVPDWKND 420
  421 TESSQNVNNN KNNNTAGFCG ECASNGYIQE TVSSGEKSHH NHHEFDSSED KSCSSVHGRF 480
  481 ADMWGLRESY SDDGEKQSSR KVRSGRWSEN EMRRELRWLK ARHKIQLMKM RGQTICETPI 540
  541 EISLTPGTSV SLPLLYRAIS LPVDAVDM

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..297] PSI-BLAST 56.0 Crystal structure of the kinase domain of WNK1, a kinase that causes a hereditary form of hypertension
    2 View Details [298..431] FFAS03 1.95 No description for 2v3sA was found.
    3 View Details [432..568] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.49988294224815 bayes_pls_golite062009
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • kinase activity
    		•  5.3287080791198 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.96052051118534 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • transferase activity
    		•  3.97138602499442 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  1.3898059094397 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.38496328649031 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  1.27291233344322 bayes_pls_golite062009
  • protein binding
    		•  1.22565748038754 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.499492353295369 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.48345772948903 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.37115026509016 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  0.35402045013148 bayes_pls_golite062009
  • signal transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.08504542461349 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.0556163711947139 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.00652065412910241 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle