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Protein Overview: MUTS_ECOBW

General Information:
Name(s) found: MUTS_ECOBW [Swiss-Prot]
Description(s) found:
Found 4 descriptions.
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  • DNA mismatch repair protein MutS OS=Escherichia coli (strain K12 / MC4100 / BW2952) GN=mutS PE=3 SV=1 [Swiss-Prot]
    • Organism: Escherichia coli BW2952
    Length: 853 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAIENFDAH TPMMQQYLRL KAQHPEILLF YRMGDFYELF YDDAKRASQL LDISLTKRGA  60
   61 SAGEPIPMAG IPYHAVENYL AKLVNQGESV AICEQIGDPA TSKGPVERKV VRIVTPGTIS 120
  121 DEALLQERQD NLLAAIWQDS KGFGYATLDI SSGRFRLSEP ADRETMAAEL QRTNPAELLY 180
  181 AEDFAEMSLI EGRRGLRRRP LWEFEIDTAR QQLNLQFGTR DLVGFGVENA PRGLCAAGCL 240
  241 LQYAKDTQRT TLPHIRSITM EREQDSIIMD AATRRNLEIT QNLAGGAENT LASVLDCTVT 300
  301 PMGSRMLKRW LHMPVRDTRV LLERQQTIGA LQDFTAGLQP VLRQVGDLER ILARLALRTA 360
  361 RPRDLARMRH AFQQLPELRA QLETVDSAPV QALREKMGEF AELRDLLERA IIDTPPVLVR 420
  421 DGGVIASGYN EELDEWRALA DGATDYLERL EVRERERTGL DTLKVGFNAV HGYYIQISRG 480
  481 QSHLAPINYM RRQTLKNAER YIIPELKEYE DKVLTSKGKA LALEKQLYEE LFDLLLPHLE 540
  541 ALQQSASALA ELDVLVNLAE RAYTLNYTCP TFIDKPGIRI TEGRHPVVEQ VLNEPFIANP 600
  601 LNLSPQRRML IITGPNMGGK STYMRQTALI ALMAYIGSYV PAQKVEIGPI DRIFTRVGAA 660
  661 DDLASGRSTF MVEMTETANI LHNATEYSLV LMDEIGRGTS TYDGLSLAWA CAENLANKIK 720
  721 ALTLFATHYF ELTQLPEKME GVANVHLDAL EHGDTIAFMH SVQDGAASKS YGLAVAALAG 780
  781 VPKEVIKRAR QKLRELESIS PNAAATQVDG TQMSLLSVPE ETSPAVEALE NLDPDSLTPR 840
  841 QALEWIYRLK SLV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..853] PSI-BLAST 1000.0 DNA repair protein MutS, domain III; DNA repair protein MutS, the C-terminal domain; DNA repair protein MutS, domain II; DNA repair protein MutS, domain I

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • mismatched DNA binding
    		•  7.6300905919597 bayes_pls_golite062009
    		• 6.67853997762091 bayes_pls_golite062009
  • guanine/thymine mispair binding
    		•  6.45283004617788 bayes_pls_golite062009
  • DNA insertion or deletion binding
    		•  6.26024791706598 bayes_pls_golite062009
  • single base insertion or deletion binding
    		•  5.15853852267378 bayes_pls_golite062009
  • dinucleotide insertion or deletion binding
    		•  4.09431251446007 bayes_pls_golite062009
  • oxidized purine DNA binding
    		•  3.84835351634579 bayes_pls_golite062009
  • oxidized DNA binding
    		•  3.84835351634579 bayes_pls_golite062009
  • single guanine insertion binding
    		•  3.84835351634579 bayes_pls_golite062009
  • DNA secondary structure binding
    		•  3.18179842526435 bayes_pls_golite062009
  • dinucleotide repeat insertion binding
    		•  3.17347240690102 bayes_pls_golite062009
  • loop DNA binding
    		•  3.13510929288157 bayes_pls_golite062009
  • mismatch repair complex binding
    		•  2.99730753457176 bayes_pls_golite062009
  • single thymine insertion binding
    		•  2.28303894489307 bayes_pls_golite062009
  • four-way junction DNA binding
    		•  2.23712359726448 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  2.16381244011837 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.13284212711072 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  2.11265775498161 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  2.11046854230259 bayes_pls_golite062009
  • double-strand/single-strand DNA junction binding
    		•  1.91034220759707 bayes_pls_golite062009
  • MutLalpha complex binding
    		•  1.83584397705627 bayes_pls_golite062009
  • hydrolase activity
    		•  1.66122526893602 bayes_pls_golite062009
  • binding
    		•  1.62320027057768 bayes_pls_golite062009
  • ATPase activity
    		•  1.53315090215319 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  1.1653223755451 bayes_pls_golite062009
  • Y-form DNA binding
    		•  1.0681332518071 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.8104901979223 bayes_pls_golite062009
  • helicase activity
    		•  0.701689608967233 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.503971340374059 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.269513772401086 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  0.146865639513637 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  0.146865639513637 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.11598665103566 bayes_pls_golite062009
  • nucleotide binding
    		•  0.114848452385726 bayes_pls_golite062009
  • DNA binding
    		•  0.111331583742205 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.10713474095071 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.0916519414118148 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.0915913646217636 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle