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Protein Overview: lig-1

General Information:
Name(s) found: lig-1 / CE37480 [WormBase]
Description(s) found:
Found 16 descriptions.
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  • WBGene00002985 locus:lig-1 DNA ligase 1 status:Partially_confirmed UniProt:Q27474 protein_id:CAA98242.2 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 773 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: embryonic cleavage [IMPLink to PubMed article]
    DNA repair [IEALink to PubMed article]
    DNA replication [IEALink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed article]
    DNA recombination [IEALink to PubMed article]
    cytokinesis [IMPLink to PubMed article]
    Molecular Function: ATP binding [IEALink to PubMed article]
    DNA binding [IEALink to PubMed article]
    DNA ligase (ATP) activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFFSKAGKAA VEWAKGSKVP YKEFALTLEK IEELSGKKKV DELAQFFTKV LDFSPDDLTA  60
   61 CVYMSVNQLG PSYEGLELGV AENSLIKAVA KATGRTEGKI KEDLRAKGDL GTVAQQSRSN 120
  121 QKMLAVPKAL TVPTVFNKLT EIAKLSGTSA MNKKVDAISA LLIACQGIEA RFLVRMLAGK 180
  181 MRIGLGEQSV LSALGHAFTL SKITDQKVRG DKLDSLKDAN VKRVKTAYCE CPNYNRLIEV 240
  241 ALTEGVEALV EKCKLSPGIP LKPMLAHPTK GIDEIMRRFR NQTMTCEWKY DGERGQIHKR 300
  301 EDGQIFIYSR NQENNTTKYP DIIEKISSCI GDGVTSFIVD AEVVAIDEAG LILPFQVLST 360
  361 RKRKNATDDN GVKVVVFLFD LLYFNGEPLV RKPLRKRREL LRTNFKKIDG SFYFATSVDT 420
  421 NDTDEINSFF DEAVQNKCEG LMIKTLDTEA TYEISRRSHS WLKMKKDYVD GVGDTLDLVV 480
  481 MGAYSGVGKR TGVYGGYLLG CYNPTTEEYE SVCKIGTGFT DEDLAEQYKI LQDKKIDKSP 540
  541 SYYQFDHTLK PDDTFSPYLV FEVKCADITI SPRHKAASGL TDDGKGISLR FPRFLRIRDD 600
  601 KNSDDATSSE QVLEMYKNQE AFANQKIEKA DAVDEDDEFE EKEDEEEELN MTNVSEGSSK 660
  661 ENPVKEEIKK ETPKSVSPKK FEKKPPVKSS PVNKSPVKSS PIKKEAEKKK GPVASIFSSS 720
  721 TKKNEKDVKV ESPSPIRKKK LPSDSDESDE ETSTNKKQPA KKRSRVAIDS DSD

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..635] PSI-BLAST 161.0 Crystal Structure of Human DNA Ligase I bound to 5'-adenylated, nicked DNA
    2 View Details [636..773] FFAS03 1.77 No description for 2j63A was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ligase activity, forming phosphoric ester bonds
    		•  4.3248432594553 bayes_pls_golite062009
  • DNA ligase activity
    		•  4.32201730952065 bayes_pls_golite062009
  • DNA ligase (NAD+) activity
    		•  3.23439045843438 bayes_pls_golite062009
  • catalytic activity
    		•  2.52414801555837 bayes_pls_golite062009
  • ligase activity
    		•  1.91469215096842 bayes_pls_golite062009
  • DNA ligase (ATP) activity
    		•  1.83677193007569 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle