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Protein Overview: AP2A2_ARATH

General Information:
Name(s) found: AP2A2_ARATH [Swiss-Prot]
Description(s) found:
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  • gi|20466360|gb|AAM20497.1| alpha-adaptin C-like protein [Arabidopsis thaliana] [NCBI NR]
  • gi|15242964|ref|NP_197670.1| adaptin family protein [Arabidopsis thaliana] [NCBI NR]
  • AP-2 complex subunit alpha-2 OS=Arabidopsis thaliana GN=ALPHAC-AD PE=1 SV=1 [Swiss-Prot]
  • alpha-adaptin C-like protein [Arabidopsis thaliana]gi|15242964|ref|NP_197670.1| adaptin family protein [Arabidopsis thaliana] [nrdb_11152004_Chlamydomonas]
  • | Symbols: | adaptin family protein | chr5:7590103-7597831 REVERSE [TAIR_Arabidopsis_na_04-12-2008_con_reversed.fasta]
  • unknown protein [Arabidopsis thaliana] [nr-271106-contam.fasta]
  • alpha-adaptin C-like protein [Arabidopsis thaliana] [nr-271106-contam.fasta]
  • | Symbols: | Adaptor protein complex AP-2, alpha subunit | chr5:7590100-7597828 REVERSE LENGTH=1013 [TAIR_A_Thaliana_10_12-14-2010_reversed.fasta]
    • Organism: Arabidopsis thaliana
    Length: 1013 amino acids

    Gene Ontology:
    Cellular Component: plasma membrane [IDA]
    Biological Process: vesicle-mediated transport [IEA]
    protein transport [IEA]
    intracellular protein transport [IEA]
    Molecular Function: protein binding [IEA]
    protein transporter activity [IEA]
    binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTGMRGLSVF ISDVRNCQNK EAERLRVDKE LGNIRTCFKN EKVLTPYKKK KYVWKMLYIH  60
   61 MLGYDVDFGH MEAVSLISAP KYPEKQVGYI VTSCLLNENH DFLKLAINTV RNDIIGRNET 120
  121 FQCLALTLVG NIGGRDFAES LAPDVQKLLI SSSCRPLVRK KAALCLLRLF RKNPDAVNVD 180
  181 GWADRMAQLL DERDLGVLTS STSLLVALVS NNHEAYSSCL PKCVKILERL ARNQDVPQEY 240
  241 TYYGIPSPWL QVKAMRALQY FPTIEDPSTR KALFEVLQRI LMGTDVVKNV NKNNASHAVL 300
  301 FEALSLVMHL DAEKEMMSQC VALLGKFISV REPNIRYLGL ENMTRMLMVT DVQDIIKKHQ 360
  361 SQIITSLKDP DISIRRRALD LLYGMCDVSN AKDIVEELLQ YLSTAEFSMR EELSLKAAIL 420
  421 AEKFAPDLSW YVDVILQLID KAGDFVSDDI WFRVVQFVTN NEDLQPYAAS KAREYMDKIA 480
  481 IHETMVKVSA YILGEYGHLL ARQPGCSASE LFSILHEKLP TVSTPTIPIL LSTYAKLLMH 540
  541 AQPPDPELQK KVWAVFKKYE SCIDVEIQQR AVEYFELSKK GPAFMDVLAE MPKFPERQSS 600
  601 LIKKAENVED TADQSAIKLR AQQQPSNAIV LADPQPVNGA PPPLKVPILS GSTDPESVAR 660
  661 SLSHPNGTLS NIDPQTPSPD LLSDLLGPLA IEAPPGAVSY EQHGPVGAEG VPDEIDGSAI 720
  721 VPVEEQTNTV ELIGNIAERF HALCLKDSGV LYEDPHIQIG IKAEWRGHHG RLVLFMGNKN 780
  781 TSPLTSVQAL ILPPAHLRLD LSPVPDTIPP RAQVQSPLEV MNIRPSRDVA VLDFSYKFGT 840
  841 NVVSAKLRIP ATLNKFLQPL QLTSEEFFPQ WRAISGPPLK LQEVVRGVRP LALPEMANLF 900
  901 NSFHVTICPG LDPNPNNLVA STTFYSETTG AMLCLARIET DPADRTQLRL TVGSGDPTLT 960
  961 FELKEFIKEQ LITIPMGSRA LVPAAGPAPS PAVQPPSPAA LADDPGAMLA GLL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..636] PSI-BLAST 96.0 Adaptin alpha C subunit N-terminal fragment
    2 View Details [637..733] deduced N/A No confident structure predictions are available.
    3 View Details [734..1013] PSI-BLAST 78.522879 Crystal structure of the alpha-adaptin appendage domain, from the AP2 adaptor complex, bound to 2 peptides from Synaptojanin170

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • clathrin binding
    		•  4.70716704570713 bayes_pls_golite062009
  • protein transporter activity
    		•  4.58709163830613 bayes_pls_golite062009
  • transporter activity
    		•  2.48700774379895 bayes_pls_golite062009
  • binding
    		•  2.4389817190572 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  2.26725422172281 bayes_pls_golite062009
  • protein binding
    		•  1.63705839411934 bayes_pls_golite062009
  • protein transmembrane transporter activity
    		•  1.4515576307774 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.28481004323799 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.09652988954158 bayes_pls_golite062009
  • signal transducer activity
    		•  0.877307852212156 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.877307852212156 bayes_pls_golite062009
  • signal sequence binding
    		•  0.57106697498903 bayes_pls_golite062009
  • nuclear localization sequence binding
    		•  0.342853430440159 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.294257360897755 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.252495966234234 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.248585912061178 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  0.226380819487924 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  0.217517113570989 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  0.178770060806735 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  0.175241020572885 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  0.174922130116569 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.100181463251306 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.0635404099346928 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.0548082069333885 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.052195223119721 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.0405268469927988 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle