YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|30231224, gi\|...
Organism:	Mus musculus
Length:	217 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|30231224, gi|....

Description	E-value	Query Range	Subject Range
HAND2_RAT - Heart- and neural crest derivatives-expressed protein 2 OS=Rattus norvegicus GN=Hand2 PE=2 SV=1 gi\|109076189 - gi\|109076189\|ref\|XP_001085842.1\| PREDICTED: similar to heart and neural crest derivatives expressed ... gi\|114596892 - gi\|114596892\|ref\|XP_001156041.1\| PREDICTED: similar to dHand protein [Pan troglodytes] HAND2 - heart and neural crest derivatives expressed 2 HAND2_MOUSE - Heart- and neural crest derivatives-expressed protein 2 OS=Mus musculus GN=Hand2 PE=1 SV=3 gi\|208968475, gi... - gi\|225000970\|gb\|AAI72639.1\| Heart and neural crest derivatives expressed transcript 2 [synthetic con...	194.0	[0..1]	[217..1]
gi\|1130500 - gi\|1130500\|gb\|AAC52338.1\| dHAND	181.0	[0..1]	[217..1]
HAND2_XENLA - Heart- and neural crest derivatives-expressed protein 2 OS=Xenopus laevis GN=hand2 PE=2 SV=1	180.0	[0..1]	[217..1]
gi\|109076191 - gi\|109076191\|ref\|XP_001085733.1\| PREDICTED: similar to heart and neural crest derivatives expressed ...	175.0	[0..1]	[217..1]
gi\|68354996, gi\|... - gi\|68354996\|ref\|XP_694809.1\| PREDICTED: similar to dHAND [Danio rerio], gi\|122890476\|emb\|CAM13338.1\|...	174.0	[0..1]	[217..1]
HAND2_CHICK - Heart- and neural crest derivatives-expressed protein 2 OS=Gallus gallus GN=HAND2 PE=2 SV=1	169.0	[0..1]	[217..1]
gi\|72533403 - gi\|72533403\|gb\|AAI01407.1\| HAND2 protein [Homo sapiens]	167.0	[0..1]	[217..1]

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Predicted Domain #1

Region A:
Residues: [1-93]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLVGGFPHH PVVHHEGYPF AAAAAAAAAA AASRCSHEEN PYFHGWLIGH PEMSPPDYSM  60
   61 ALSYSPEYAS GAAGLDHSHY GGVPPGAGPP GLG

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [94-217]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GPRPVKRRGT ANRKERRRTQ SINSAFAELR ECIPNVPADT KLSKIKTLRL ATRYIAYLMD  60
   61 LLAKDDQNGE AEAFKAEIKK TDVKEEKRKK ELNEILKSTV SSNDKKTKGR TGWPQHVWAL 120
  121 ELKQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	18.221849
Match:	1nkpA
Description:	Myc prot-oncogene protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transcription regulator activity	5.38658950816179	bayes_pls_golite062009
DNA binding	5.18654839258297	bayes_pls_golite062009
nucleic acid binding	5.05768805749761	bayes_pls_golite062009
transcription factor activity	4.78039531631248	bayes_pls_golite062009
transcription activator activity	3.87875547821718	bayes_pls_golite062009
binding	3.81829206350975	bayes_pls_golite062009
sequence-specific DNA binding	3.42035985454056	bayes_pls_golite062009
RNA polymerase II transcription factor activity	3.39500382187264	bayes_pls_golite062009
protein binding	2.64975291677725	bayes_pls_golite062009
transcription factor binding	2.61163564741984	bayes_pls_golite062009
transcription repressor activity	2.58751248599889	bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding	2.42306484786159	bayes_pls_golite062009
transcription corepressor activity	2.03674713048499	bayes_pls_golite062009
promoter binding	1.56457725225443	bayes_pls_golite062009
transcription cofactor activity	1.52770895937238	bayes_pls_golite062009
transcription coactivator activity	1.39260472877067	bayes_pls_golite062009
protein heterodimerization activity	0.53175615551166	bayes_pls_golite062009
structure-specific DNA binding	0.3655541712365	bayes_pls_golite062009
double-stranded DNA binding	0.29436315000437	bayes_pls_golite062009
protein dimerization activity	0.20674648626116	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: