YRC Public Data Repository - Protein Structure Prediction

Protein:	shn-PD
Organism:	Drosophila melanogaster
Length:	2577 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for shn-PD.

Description	E-value	Query Range	Subject Range
gi\|109458488 - gi\|109458488\|ref\|XP_574414.2\| PREDICTED: similar to Zinc finger protein 208 [Rattus norvegicus]	1310.0	[0..1454]	[2575..265]

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Predicted Domain #1

Region A:
Residues: [1-185]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MARRKGSGRG KSTVNSRKSA LETAREKTKD EPTANTSQDN KFDNNMENAT TTTAKHYKTA  60
   61 GKQYKTNKVN NTRRATAAAA AAAAAAATTT VTTAATPTKK RTYRETATAT IVTQRSTNKA 120
  121 NIAAAIALAA ATEATASASA SATATATDAT LTASKAAATA AATTDAASGN SNSSSKPSTS 180
  181 TRDKL

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.48
Match:	1h1kI
Description:	THE BLUETONGUE VIRUS (BTV) CORE BINDS DSRNA
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [186-364]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GEVPLPTVDS NHIISNNNNN NNNNNTSNNN NNNHHSDNSI SENNYEFKSR DKASLSDSKM  60
   61 TLQQMAAVSS NQEPVAPNVA NTMSNSSIIN SQQTTVNATP ATDEAPLGDR SNISRYLHKK 120
  121 FKRLASTTEV DSWSATNGGG ALQASGDAVR TTSLSSNSSL SPPPTTPLAN GHHLMTQQQ

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [365-435]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SHQQVQQQQQ QQQTPPPSVA IHEFSANFVN SNHVNAIGHE ESIISNSGYK AAGRTRTPLA  60
   61 NSNSNTNSTS N

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4

Region A:
Residues: [436-536]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SNSNHAANAT LSPASFAQHQ QLTQPTTVSP GIPGGAAAPN PACEKSGRYV CQYCNLICAK  60
   61 PSVLEKHIRA HTNERPYPCD TCGIAFKTKS NLYKHCRSRS H

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	10.69897
Match:	1f2iG
Description:	ZIF268
Matching Structure (courtesy of the PDB):

Predicted Domain #5

Region A:
Residues: [537-708]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AARARGLEVP ADADDGLSDQ DAELSNSSSE LPSRAGSPYE EPINSPTPSP STLSAAKSAY  60
   61 IQQPPLPTYM QQLPLGSPAA GTLPPTTADN HHSATAQHRQ SIDYKPYKPK FHNASLYSCS 120
  121 SKELQQQQQQ LQIQQQQQQH QLAQQKLSIQ LPLVQQPSLA HPTLSPSTQM KM

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	19.0
Match:	1tf6A
Description:	Transcription factor IIIA, TFIIIA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transcription regulator activity	4.70988788192472	bayes_pls_golite062009
nucleic acid binding	4.58713908116892	bayes_pls_golite062009
DNA binding	4.56219307357342	bayes_pls_golite062009
transcription factor activity	3.50954949535763	bayes_pls_golite062009
transcription repressor activity	3.27542149084008	bayes_pls_golite062009
RNA polymerase II transcription factor activity	3.22082323675675	bayes_pls_golite062009
binding	3.10743787485868	bayes_pls_golite062009
transcription activator activity	2.19952417915035	bayes_pls_golite062009
chromatin binding	2.18464662431232	bayes_pls_golite062009
specific RNA polymerase II transcription factor activity	1.63161912031789	bayes_pls_golite062009
sequence-specific DNA binding	1.42975942698743	bayes_pls_golite062009
transcription factor binding	1.39608963544799	bayes_pls_golite062009
transcription corepressor activity	1.34049786451995	bayes_pls_golite062009
protein binding	1.00484935878505	bayes_pls_golite062009
transcription cofactor activity	0.77874411480713	bayes_pls_golite062009
catalytic activity	0.245893663605433	bayes_pls_golite062009

Predicted Domain #6

Region A:
Residues: [709-777]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KHHINSHQIQ LQLQQQQSLL AQQSLLAAMP PGGVYYLGQP SYYNQDTAAA IHQHALAIQQ  60
   61 FQIHLAQQQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	24.154902
Match:	1meyC
Description:	Designed zinc finger protein
Matching Structure (courtesy of the PDB):

Predicted Domain #7

Region A:
Residues: [778-886]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QQQQQQHPPL VKATPPMQQP PSLPPQQLVR ANSQISSVAT APATPTPAAN LSTFASSSGG  60
   61 KQVNVAKVQE HISKLISQNE AIVENKEILL QKKYPKQLSR SRSFNNANS

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #8

Region A:
Residues: [887-1056]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NNASQHGSNA SALHANNSQN NTNAQMPERE TKVNLAQAIF QKQQHQLQQQ QQQQITQQQQ  60
   61 QQLEQQNYYT YIQQQQECQQ QQLEPPNGVV KRNAYKPGVV MTTPVKQQQQ LPPPPSPLPM 120
  121 QTMQYRQDPA TPVTKIEQPT TAVPVMPLNL SAKPKPTLVT VPVSSLSTSS

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #9

Region A:
Residues: [1057-1246]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LAPTPTTSTN PTSSSKTAPP PAQVNNSIIK NLLLNARGLA VPIGEGDDAV YSCPICASEF  60
   61 RSADDLKLHN STYCQDASSS APMSPASSPF RSNSISLSLP ELKSHMANSK NPLSLAKLAW 120
  121 SQLKTKRSSL VLSRLSAAQT PARTSTVTAP TVTASAPAPA VATVTAPSSA PAPQIEALRF 180
  181 VDAPLPSPGP

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #10

Region A:
Residues: [1247-1466]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LLGKTPLVDY AQQSTPRKAQ DSVVITKMHE DRQFVIEAQP AKRIKTSDLV VASSSQQPTS  60
   61 FNFSFNNQNS SNSVPELQSS KEERLRRFTS SGGSMIPISE CPDLDNSPKM IRTPLLSGGS 120
  121 FQDVSVKVNN ETGSSSKERK LMALVSGSGL LGVSSGPQHF QFPPINSITA FNPLTLPPMS 180
  181 GGDKTTPVTP IPHVPGMPGP GSLTPQMPLL PPPPQQLQLP

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #11

Region A:
Residues: [1467-1673]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IPSSRGRSPN RKQPSPLLLG GGSGELKALS PFGGVQNVPS EFSRQPPTPA QRQALQWNSK  60
   61 EAPKKAPFNF LRMADNVKTT EPEVRHFNLE NVISGKQQEL PLTPLHVDTP NGNAPEETSP 120
  121 VASASASAKS KFLRPTSLPL KPGTFTPKRH HGITPTANTL PLISPETPRP SKSCVQLYLN 180
  181 GHAYTYLGLK CSTKMFYCTV NCPQPSY

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #12

Region A:
Residues: [1674-1875]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VAGMHKLSMY SVWQVCEENQ PHPLGFKLKQ VMALYDSRQR MLGNGSSTAM AGSGKLSYNL  60
   61 VASQQIVSSP STSSTSSAFY QGPLKTPPTV TIAALSEANV AAKANEEAQA KKLETSPSGQ 120
  121 PLVGGYESHE DYTYIRGRGR GRYVCSECGI RCKKPSMLKK HIRTHTDVRP FTCSHCNFSF 180
  181 KTKGNLTKHM QSKTHFKKCI EL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	60.30103
Match:	2i13A
Description:	No description for 2i13A was found.

Predicted Domain #13

Region A:
Residues: [1876-1995]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GINPGPMPPD SEFLDVDMDF DQQSSTSAGG RTSSMAGESD SDDYSDNESE SSDTDESKSR  60
   61 QKEHEAARGL LSLSMTPPIP QSVSPYPQLQ DTPLPAASPA NSIGSSGSQP KRLVCSFTSP 120
  121

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #14

Region A:
Residues: [1996-2118]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KPPFDYQKQE QYYSNPEESK PKRSVANEES APMDLTKPRG SILLISPSPV SVPAHDLPKS  60
   61 QAQQMHDVIF GTSGNESGFM KTLISVSDKV RISAEMEEQA KHEAEGEDVQ LQTYIKEHAL 120
  121 HQA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	16.522879
Match:	2cshA
Description:	Solution structure of tandem repeat of the zf-C2H2 domains of human zinc finger protein 297B
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transcription regulator activity	4.70988788192472	bayes_pls_golite062009
nucleic acid binding	4.58713908116892	bayes_pls_golite062009
DNA binding	4.56219307357342	bayes_pls_golite062009
transcription factor activity	3.50954949535763	bayes_pls_golite062009
transcription repressor activity	3.27542149084008	bayes_pls_golite062009
RNA polymerase II transcription factor activity	3.22082323675675	bayes_pls_golite062009
binding	3.10743787485868	bayes_pls_golite062009
transcription activator activity	2.19952417915035	bayes_pls_golite062009
chromatin binding	2.18464662431232	bayes_pls_golite062009
specific RNA polymerase II transcription factor activity	1.63161912031789	bayes_pls_golite062009
sequence-specific DNA binding	1.42975942698743	bayes_pls_golite062009
transcription factor binding	1.39608963544799	bayes_pls_golite062009
transcription corepressor activity	1.34049786451995	bayes_pls_golite062009
protein binding	1.00484935878505	bayes_pls_golite062009
transcription cofactor activity	0.77874411480713	bayes_pls_golite062009
catalytic activity	0.245893663605433	bayes_pls_golite062009

Predicted Domain #15

Region A:
Residues: [2119-2286]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KIKQSQFSRS YLINTLYTAA SPVMSSSSTL FTANSRPVMS VNEVPSIEVH EVKTPEAIES  60
   61 PRSAPEQAPV ILAQIAQEEN EEPNIAEPHN ANLPAAVQQP DVNEFTGVLG NPTAPPTSSV 120
  121 TATSVSTTTA APVAPSSTAN STQPAQRTVI VGEDGFKSST PTSKSGDL

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.31
Match:	2j63A
Description:	No description for 2j63A was found.

Predicted Domain #16

Region A:
Residues: [2287-2415]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QHVSYGRGVP PAPIAGDARP TCTMCSKTFQ RQHQLTLHMN IHYMERKFKC EPCSISFRTQ  60
   61 GHLQKHERSE AHKNKVMMTS TFGVPTTSNP RPFECTDCKI AFRIHGHLAK HLRSKTHVQK 120
  121 LECLQKLPF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	19.221849
Match:	1ubdC
Description:	Ying-yang 1 (yy1, zinc finger domain)
Matching Structure (courtesy of the PDB):

Predicted Domain #17

Region A:
Residues: [2416-2577]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GTYAEIERAG ISLTEIDTSD CENSLISLKL LAQKLQEKDP GKLSSYTTPS GMMQLAQDAA  60
   61 GPVSQDSASE DGFSAAIASA IASLDNDSAG NTPKRASSMS EDETVANGLN HSLKRRLPGS 120
  121 FSSTGEESDN PPESSGEKRA RSGQELPVPV AVPVAASAAA SN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	14.0
Match:	2yt9A
Description:	No description for 2yt9A was found.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: