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View Structure Prediction Details

Protein: Psi-PC
Organism: Drosophila melanogaster
Length: 797 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Psi-PC.

Description E-value Query
Range
Subject
Range
gi|68365020 - gi|68365020|ref|XP_689672.1| PREDICTED: similar to KH-type splicing regulatory protein (FUSE binding...
318.0 [0..11] [689..324]

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Predicted Domain #1
Region A:
Residues: [1-112]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDFQQQGIN QSQALAQAIQ RAKQIAAKIQ PSQQGGGTAG PSPPSSGGGP GFKRINDDGD  60
   61 SGPESKRSLG SPEYANNSSN MSSGSGGGGG GGGGPGGASI TQAIAQAAAV AA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [113-296]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RLAASAGTSC EEQIRLPESV AGAFMGRSSN DTITHIQAES GVKVQVMQDQ DRVIMLRGQR  60
   61 DTVTKGREMI QNMANRAGGG QVEVLLTINM PPPGPSGYPP YQEIMIPGAK VGLVIGKGGD 120
  121 TIKQLQEKTG AKMIIIQDGP NQELIKPLRI SGEAQKIEHA KQMVLDLIAQ KDAQGQQQGG 180
  181 RGGG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 27.522879
Match: 2annA
Description: No description for 2annA was found.

Predicted Domain #3
Region A:
Residues: [297-502]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GGGGGPGMGF NNFNNGNGGE STEVFVPKIA VGVVIGKGGD MIRKIQTECG CKLQFIQGKN  60
   61 DEMGDRRCVI QGTRQQVDDA KRTIDGLIEN VMQRNGMNRN GNGGGGGPGG DSGNSNYGYG 120
  121 YGVNHAQGGR EEITFLVPAS KCGIVIGRGG ETIKLINQQS GAHTEMDRNA SNPPNEKLFK 180
  181 SKGTTDQVEA ARQMISEKIN MELNVI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 19.0
Match: 1j4wA
Description: Far upstream binding element, FBP, KH3 and KH4 domains
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 6.76415077523249 bayes_pls_golite062009
mRNA binding 5.07455187994216 bayes_pls_golite062009
4.82131641133915 bayes_pls_golite062009
nucleic acid binding 4.78650555542715 bayes_pls_golite062009
binding 3.45962790790935 bayes_pls_golite062009
transcription regulator activity 2.28364833275102 bayes_pls_golite062009
poly-pyrimidine tract binding 2.05765562493656 bayes_pls_golite062009
DNA binding 2.03207983673692 bayes_pls_golite062009
transcription repressor activity 1.87340518658135 bayes_pls_golite062009
transcription factor activity 1.30278154718684 bayes_pls_golite062009
protein binding 1.16541072642796 bayes_pls_golite062009
single-stranded RNA binding 0.981003625136521 bayes_pls_golite062009
mRNA 3'-UTR binding 0.489176583045793 bayes_pls_golite062009
transcription activator activity 0.324382863054631 bayes_pls_golite062009
structure-specific DNA binding 0.32222928997178 bayes_pls_golite062009
transcription factor binding 0.254024117548226 bayes_pls_golite062009
catalytic activity 0.113112541746059 bayes_pls_golite062009
single-stranded DNA binding 0.1069917291606 bayes_pls_golite062009
sequence-specific DNA binding 0.0321875054165348 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [503-615]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SRKPIGGGPG GGGGNSGGGQ NNSHHNQQQG GYGGQNQMQG GDPNSGAGYQ QQPWGGPYGQ  60
   61 QGWDPSGQQQ QMAMANQGGS AAGGASGGQD YSAQWIEYYK QMGCHREAEM IEQ

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [616-797]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QMKAKQAGGS SGPVQQQQPQ QQQQSQQQTG GAGAGGADYS AQWAEYYRSV GKIEEAEAIE  60
   61 KTLKNKQQNG SGGQSSTPNP SQGGSGQQQP NPAAAAAAAA AAAAAAGGYG QSMTPTQYAQ 120
  121 YSQYYAAAAA AGGQPQGAPQ PGGGQSGGPP GNYPGNYPGA GYGGYPGAPG QQQQKSHKND 180
  181 NH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 7.0
Match: 1m2vB
Description: Sec24
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle