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View Structure Prediction Details

Protein: Spn4-PI
Organism: Drosophila melanogaster
Length: 406 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Spn4-PI.

Description E-value Query
Range
Subject
Range
gi|481621 - gi|481621|pir||S38962 serpin - pig
370.0 [0..38] [403..1]

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Predicted Domain #1
Region A:
Residues: [1-406]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDYRLVPCGC WLLPLLGLAL FPFPPVHTAD VTMADAAHQE FARRLALFSI NVYGKLSGQK  60
   61 PGENIVFSPF SIQTCAAMAR LGAENETATQ LDQGLGLASS DPEQIAHSFH QVLAAYQDSQ 120
  121 ILRIANKIFV MDGYQLRQEF DQLLSKQFLS AAQSVDFSKN VQAAATINNW VEQRTNHLIK 180
  181 DLVPADVLNS ESRLVLVNAI HFKGTWQHQF AKHLTRPDTF HLDGERTVQV PMMSLKERFR 240
  241 YADLPALDAM ALELPYKDSD LSMLIVLPNT KTGLPALEEK LRLTTLSQIT QSLYETKVAL 300
  301 KLPRFKAEFQ VELSEVFQKL GMSRMFSDQA EFGKMLQSPE PLKVSAIIHK AFIEVNEEGT 360
  361 EAAAATVWRV MAVAAFSRKH FIANHPFAFY VKTHYDLPIF TGRYLG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 93.39794
Match: 1by7A
Description: Plasminogen activator inhibitor-2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
serine-type endopeptidase inhibitor activity 6.13717785773502 bayes_pls_golite062009
peptidase inhibitor activity 6.07523919900796 bayes_pls_golite062009
endopeptidase inhibitor activity 6.01194624525726 bayes_pls_golite062009
enzyme inhibitor activity 3.67290572457064 bayes_pls_golite062009
protease binding 2.69747551802498 bayes_pls_golite062009
enzyme regulator activity 2.47388770421699 bayes_pls_golite062009
binding 2.02049891212041 bayes_pls_golite062009
protein binding 1.90236643189719 bayes_pls_golite062009
glycosaminoglycan binding 1.61358221181146 bayes_pls_golite062009
nucleic acid binding 1.46959492426289 bayes_pls_golite062009
DNA binding 1.31854786197421 bayes_pls_golite062009
transporter activity 1.29851101299849 bayes_pls_golite062009
heparin binding 1.21540270241849 bayes_pls_golite062009
receptor activity 1.1966923866485 bayes_pls_golite062009
transmembrane receptor activity 1.14424818451335 bayes_pls_golite062009
signal transducer activity 1.12659599250323 bayes_pls_golite062009
molecular transducer activity 1.12659599250323 bayes_pls_golite062009
transmembrane transporter activity 1.07876412297114 bayes_pls_golite062009
receptor binding 1.0390886965673 bayes_pls_golite062009
polysaccharide binding 0.99559313679422 bayes_pls_golite062009
type 2 angiotensin receptor binding 0.92552398196189 bayes_pls_golite062009
collagen binding 0.307023895861541 bayes_pls_golite062009
active transmembrane transporter activity 0.262958899612658 bayes_pls_golite062009
growth factor activity 0.21183671094477 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle