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View Structure Prediction Details

Protein: FBpp0306393, e(y...
Organism: Drosophila melanogaster
Length: 2006 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FBpp0306393, e(y....

Description E-value Query
Range
Subject
Range
gi|21391996 - gi|21391996|gb|AAM48352.1| LD10526p [Drosophila melanogaster]
667.0 [0..191] [2006..28]

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Predicted Domain #1
Region A:
Residues: [1-88]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNDLRQQQMV AATSSSGSES GTAVESAAAT STAGSAGAAG RPQSNCSANS NAKSVAASST  60
   61 SEEEQRVSST SSPAQRDQQL NADRDREQ

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [89-250]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EPEPQQQQQR EEALQHQHNQ PGHITSTTAS PPPTLPPPTT PCDDAPSTTG ASASASSASG  60
   61 EAPSAASAAG AAGGPMAATA LEVESEERDG HKIILKLSKH ANPNSNANES QPGGDERRVE 120
  121 PLRIQLPCGG AEGGLVAKQQ DAFDADASSC SSSCAEDEVA TT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [251-458]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LGQQLRNTPH IVPKLTIRAA NERRVGSVVP KLTIKLPENP AASGSNSNSG SCSAAVSGAQ  60
   61 SAMPAKNDAH LSSLSPASAS SSSASSSSSS SSSSSLAEMQ TVPKLMIKTT LAGSSCISSS 120
  121 EELPQQQQQI PKLTIKTGGG GQEHVHTVIM THDLNNAQSI PKLTIKTKSI EMIEDEQAAK 180
  181 LEQQLQPLPK LTIKNLCSPK HKVRAVLE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [459-640]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EKPPTAASKL AIPKPTPNPT PAPMTNGGES NSSSQEFCGF SDPDADIAAP ASDDVRRNSD  60
   61 DMVIDDSLSK EHDPKIFHNL PPMPASNGIA SGGSKASKAS KSAQSQHNVV DMVDLTSSPS 120
  121 PGSSPTHVPN NFTGRISPKG LLIDCLRMQT AIGCYVPEEA DSRVRPAASP NSNILLSQLT 180
  181 AP

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [641-768]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AKSFTTTTPK SKSSKYPQLT ERLMANGSGT GGGSVIAAES EAVVGPLPAA NPAQSIIESI  60
   61 EILDTPDGSP RVAYMDEDSN PMLNKHLQTI HKLAMDHGVE QRMDTQDNNN ENHLKRTNSE 120
  121 GNESPSSR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [769-902]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPPSKQRRLD NDENDQQTQN CHDPARKCSE SLQALPPSHR SRKQKHERIL NTDLEGSLFP  60
   61 PTQQQSISTP DQNGALSSEV EGEDAKAQDP LEPATPQPPP VATPAGTGKK RGRPKRIQNQ 120
  121 SSPDGGGAVT PKPG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [903-1027]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TPQEEANSAV KSRRVQLLRK RLAIDMVSVG QEQADMKAKE KESSVGVPNA RVEDGLAETL  60
   61 ESPKTRDHRP LRATRRTTTS TNTNLQPTPK STRKRQSKAS VQQSQLPPPT MAQFGSSESE 120
  121 SNNNN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #8
Region A:
Residues: [1028-1087]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NSSISFALSA QIDLTMCSSS SSTSSGAAAN QQVIGGSGSS SMLPPTTILS SSDPLPDVIF  60
   61 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #9
Region A:
Residues: [1088-1284]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QPNDFSSIMA TQQLRSSRPS SISCGSTGGS QPDCHDEDNY TSALDNSGDE TALPMPPTRG  60
   61 RGRGRRSRGG RGRGSSSVDR AVSVGGTAST TPATQPRAPR MSRGASAVAK AIAMSRPRCV 120
  121 GGLKHQPDPE RLKGLFSPSP QVFEEDTRMS ADLSNSNQSM ASLMEPPLTP QKQPDFLNNE 180
  181 ESQSSMVSNV SMMDSNQ

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #10
Region A:
Residues: [1285-1353]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GQSADAILGS ALKRPKKKKM ETCVAEDTDY SASSIAEYDW PPPKGCCPSK NRDTFMIQEQ  60
   61 VALYLGITS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #11
Region A:
Residues: [1354-1583]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FKRKYPDLPR RSVDMEERNW LQEKGLVSEK LCDLGITAVW ASDILDIMYA DFFDKYEEYK  60
   61 EYIRRKHLRE IEAKQKALGL TVGAGRGLQA RDRAMLSATK WNAYFNKSRK DERQSCMDLQ 120
  121 TFTINQPQPR TAPTCTRLER STSDLIRAVA EEANIPAPPN LLPPRDYDEA FRNSDYAYPL 180
  181 TVVPDQFSMA YRQFEPAELR AYPLDTALDK PPTDLMAQLL QAKSEAVGSD 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #12
Region A:
Residues: [1584-1726]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EIKTSAPAPK DLGQEQSAIK SVTVTAPVRR SRRSTRQQTD KVRTASSSST SSAQSVSSAS  60
   61 SGNGSSSDTE SGDESDFSST SSCSSSTGAS SGAGSEDEDG NECSSSVRLS TCGVCLRSQH 120
  121 RNARDMPEAF IRCYTCRKRV HPS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.045757
Match: 2cshA
Description: Solution structure of tandem repeat of the zf-C2H2 domains of human zinc finger protein 297B
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.70988788192472 bayes_pls_golite062009
nucleic acid binding 4.58713908116892 bayes_pls_golite062009
DNA binding 4.56219307357342 bayes_pls_golite062009
transcription activator activity 3.52873291636993 bayes_pls_golite062009
transcription factor activity 3.50954949535763 bayes_pls_golite062009
transcription repressor activity 3.27542149084008 bayes_pls_golite062009
binding 3.10743787485868 bayes_pls_golite062009
sequence-specific DNA binding 2.53101891154822 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.31369346002275 bayes_pls_golite062009
protein binding 2.05530362750351 bayes_pls_golite062009
chromatin binding 1.53640935908107 bayes_pls_golite062009
transcription factor binding 1.39608963544799 bayes_pls_golite062009
transcription corepressor activity 1.34049786451995 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.0497955246512 bayes_pls_golite062009
transcription cofactor activity 0.77874411480713 bayes_pls_golite062009
catalytic activity 0.245893663605433 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 0.10146306852499 bayes_pls_golite062009

Predicted Domain #13
Region A:
Residues: [1727-1864]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CVDMPPRMVG RVRNYNWQCA GCKCCIKCRS SQRPGKMLYC EQCDRGYHIY CLGLRTVPDG  60
   61 RWSCERCCFC MRCGATKPEG LPQVAALSQA SGGPSANGDR SKAARNKRLK WVHEYRIDHV 120
  121 TKIREHAAMF CVPCARNK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 20.30103
Match: 2ysmA
Description: No description for 2ysmA was found.

Predicted Domain #14
Region A:
Residues: [1865-2006]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PAKRQSAAGA AGAAAVTPVL EATSAQTDDS PMPSPGLTTN GGRALSPTAA LSPKAAVPVA  60
   61 SLPPVLEATT VTTNIAGTIG RRQAGNAVNI TTMQCSSSSS SNFSGNGVTE DAANVTATGT 120
  121 ATAAAGAPAA TPIGIAPPPV VA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle