YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Structure Prediction Details

Protein: EMX1
Organism: Homo sapiens
Length: 257 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



[What does the above image mean?]


[Show Ginzu Version Information]


Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for EMX1.

Description E-value Query
Range
Subject
Range
gi|119620162, gi... - gi|94536800|ref|NP_004088.2| empty spiracles homolog 1 [Homo sapiens], gi|119620162|gb|EAW99756.1| e...
2.0E-33 [1..257] [34..290]
gi|76628915 - gi|76628915|ref|XP_586475.2| PREDICTED: similar to empty spiracles homolog 1 [Bos taurus]
4.0E-33 [1..257] [1..255]
gi|182887939 - gi|182887939|gb|AAI60212.1| Empty spiracles homolog 1 (Drosophila) [synthetic construct]
EMX1_MOUSE - Homeobox protein EMX1 OS=Mus musculus GN=Emx1 PE=2 SV=2
6.0E-33 [1..257] [1..257]
gi|109473809, gi... - gi|109473809|ref|XP_001073769.1| PREDICTED: similar to empty spiracles homolog 1 [Rattus norvegicus]...
2.0E-32 [1..257] [1..257]
gi|116294310 - gi|116294310|gb|AAP79287.2| hox 7 [Saccoglossus kowalevskii]
3.0E-25 [8..228] [2..221]
HXC6A_TAKRU - Homeobox protein Hox-C6a OS=Takifugu rubripes GN=hoxc6a PE=3 SV=1
8.0E-25 [13..246] [2..227]
gi|21902136 - gi|21902136|gb|AAM78420.1| Emx3 [Scyliorhinus canicula]
1.0E-24 [1..257] [1..234]
gi|745777, gi|52... - gi|745777|prf||2016458D Hox-5 gene, gi|520614|emb|CAA84517.1| Hox-5 homeodomain protein [Branchiosto...
1.0E-24 [157..236] [4..83]
gi|4322076 - gi|4322076|gb|AAD15947.1| homeobox protein [Danio rerio]
2.0E-24 [8..219] [2..207]

Back

Predicted Domain #1
Region A:
Residues: [1-132]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFQPAAKRGF TIESLVAKDG GTGGGTGGGG AGSHLLAAAA SEEPLRPTAL NYPHPSAAEA  60
   61 AFVSGFPAAA AAGAGRSLYG GPELVFPEAM NHPALTVHPA HQLGASPLQP PHSFFGAQHR 120
  121 DPLHFYPWVL RN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [133-257]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RFFGHRFQAS DVPQDGLLLH GPFARKPKRI RTAFSPSQLL RLERAFEKNH YVVGAERKQL  60
   61 AGSLSLSETQ VKVWFQNRRT KYKRQKLEEE GPESEQKKKG SHHINRWRIA TKQANGEDID 120
  121 VTSND

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 20.0
Match: 1b72A
Description: Homeobox protein hox-b1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.67711146264366 bayes_pls_golite062009
DNA binding 4.26679916438424 bayes_pls_golite062009
nucleic acid binding 4.10991419309805 bayes_pls_golite062009
transcription factor activity 3.74788993580019 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
sequence-specific DNA binding 2.16521751467289 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.96364983538233 bayes_pls_golite062009
transcription repressor activity 1.79427849359671 bayes_pls_golite062009
transcription activator activity 1.6126228397074 bayes_pls_golite062009
transcription factor binding 1.32991027110041 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.9526286147364 bayes_pls_golite062009
protein binding 0.830419844171551 bayes_pls_golite062009
chromatin binding 0.775421813815509 bayes_pls_golite062009
transcription cofactor activity 0.71989890364863 bayes_pls_golite062009
transcription corepressor activity 0.0615820877359203 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle