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View Structure Prediction Details

Protein: EMX1
Organism: Homo sapiens
Length: 257 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for EMX1.

Description E-value Query
Range
Subject
Range
gi|119620162, gi... - gi|94536800|ref|NP_004088.2| empty spiracles homolog 1 [Homo sapiens], gi|119620162|gb|EAW99756.1| e...
2.0E-33 [1..257] [34..290]
gi|76628915 - gi|76628915|ref|XP_586475.2| PREDICTED: similar to empty spiracles homolog 1 [Bos taurus]
4.0E-33 [1..257] [1..255]
gi|182887939 - gi|182887939|gb|AAI60212.1| Empty spiracles homolog 1 (Drosophila) [synthetic construct]
EMX1_MOUSE - Homeobox protein EMX1 OS=Mus musculus GN=Emx1 PE=2 SV=2
6.0E-33 [1..257] [1..257]
gi|109473809, gi... - gi|109473809|ref|XP_001073769.1| PREDICTED: similar to empty spiracles homolog 1 [Rattus norvegicus]...
2.0E-32 [1..257] [1..257]
gi|116294310 - gi|116294310|gb|AAP79287.2| hox 7 [Saccoglossus kowalevskii]
3.0E-25 [8..228] [2..221]
HXC6A_TAKRU - Homeobox protein Hox-C6a OS=Takifugu rubripes GN=hoxc6a PE=3 SV=1
8.0E-25 [13..246] [2..227]
gi|21902136 - gi|21902136|gb|AAM78420.1| Emx3 [Scyliorhinus canicula]
1.0E-24 [1..257] [1..234]
gi|745777, gi|52... - gi|745777|prf||2016458D Hox-5 gene, gi|520614|emb|CAA84517.1| Hox-5 homeodomain protein [Branchiosto...
1.0E-24 [157..236] [4..83]
gi|4322076 - gi|4322076|gb|AAD15947.1| homeobox protein [Danio rerio]
2.0E-24 [8..219] [2..207]

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Predicted Domain #1
Region A:
Residues: [1-132]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFQPAAKRGF TIESLVAKDG GTGGGTGGGG AGSHLLAAAA SEEPLRPTAL NYPHPSAAEA  60
   61 AFVSGFPAAA AAGAGRSLYG GPELVFPEAM NHPALTVHPA HQLGASPLQP PHSFFGAQHR 120
  121 DPLHFYPWVL RN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [133-257]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RFFGHRFQAS DVPQDGLLLH GPFARKPKRI RTAFSPSQLL RLERAFEKNH YVVGAERKQL  60
   61 AGSLSLSETQ VKVWFQNRRT KYKRQKLEEE GPESEQKKKG SHHINRWRIA TKQANGEDID 120
  121 VTSND

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 20.0
Match: 1b72A
Description: Homeobox protein hox-b1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.67711146264366 bayes_pls_golite062009
DNA binding 4.26679916438424 bayes_pls_golite062009
nucleic acid binding 4.10991419309805 bayes_pls_golite062009
transcription factor activity 3.74788993580019 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
sequence-specific DNA binding 2.16521751467289 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.96364983538233 bayes_pls_golite062009
transcription repressor activity 1.79427849359671 bayes_pls_golite062009
transcription activator activity 1.6126228397074 bayes_pls_golite062009
transcription factor binding 1.32991027110041 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.9526286147364 bayes_pls_golite062009
protein binding 0.830419844171551 bayes_pls_golite062009
chromatin binding 0.775421813815509 bayes_pls_golite062009
transcription cofactor activity 0.71989890364863 bayes_pls_golite062009
transcription corepressor activity 0.0615820877359203 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle