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View Structure Prediction Details

Protein: HMX2
Organism: Homo sapiens
Length: 273 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HMX2.

Description E-value Query
Range
Subject
Range
gi|114633187 - gi|114633187|ref|XP_508091.2| PREDICTED: homeo box (H6 family) 2 [Pan troglodytes]
7.0E-34 [1..273] [1..273]
gi|109090824 - gi|109090824|ref|XP_001105231.1| PREDICTED: similar to homeo box (H6 family) 2 [Macaca mulatta]
1.0E-32 [1..273] [1..273]
gi|73998968 - gi|73998968|ref|XP_544055.2| PREDICTED: similar to Homeobox protein HMX2 (Homeobox protein Nkx-5.2) ...
6.0E-32 [1..273] [1..273]
HMX2_MOUSE - Homeobox protein HMX2 OS=Mus musculus GN=Hmx2 PE=2 SV=3
4.0E-31 [1..273] [1..273]
gi|149061281, gi... - gi|157821011|ref|NP_001099773.1| H6 family homeobox 2 [Rattus norvegicus], gi|149061281|gb|EDM11704....
4.0E-30 [1..273] [1..273]
gi|4322076 - gi|4322076|gb|AAD15947.1| homeobox protein [Danio rerio]
2.0E-29 [6..216] [2..214]
gi|76615429 - gi|76615429|ref|XP_872865.1| PREDICTED: similar to homeobox A7 [Bos taurus]
2.0E-29 [16..209] [1..190]
HXA7_HETFR - Homeobox protein Hox-A7 OS=Heterodontus francisci GN=HOXA7 PE=3 SV=1
3.0E-29 [16..217] [1..203]
gi|6918885 - gi|6918885|emb|CAA59270.1| HOX 1.1 (A7) [Homo sapiens]
3.0E-29 [16..219] [1..199]

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Predicted Domain #1
Region A:
Residues: [1-135]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGSKEDAGKG CPAAGGVSSF TIQSILGGGP SEAPREPVGW PARKRSLSVS SEEEEPDDGW  60
   61 KAPACFCPDQ HGPKEQGPKH HPPIPFPCLG TPKGSGGSGP GGLERTPFLS PSHSDFKEEK 120
  121 ERLLPAGSPS PGSER

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [136-273]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PRDGGAERQA GAAKKKTRTV FSRSQVYQLE STFDMKRYLS SSERACLASS LQLTETQVKT  60
   61 WFQNRRNKWK RQLSAELEAA NMAHASAQTL VSMPLVFRDS SLLRVPVPRS LAFPAPLYYP 120
  121 GSNLSALPLY NLYNKLDY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 26.69897
Match: 1homA
Description: DETERMINATION OF THE THREE-DIMENSIONAL STRUCTURE OF THE ANTENNAPEDIA HOMEODOMAIN FROM DROSOPHILA IN SOLUTION BY 1H NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.20302368446064 bayes_pls_golite062009
DNA binding 3.910335137985 bayes_pls_golite062009
nucleic acid binding 3.70444192553266 bayes_pls_golite062009
transcription factor activity 3.41495638905535 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
sequence-specific DNA binding 2.0896307866191 bayes_pls_golite062009
protein binding 1.88087411289001 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.72533206529661 bayes_pls_golite062009
transcription repressor activity 1.55910796763122 bayes_pls_golite062009
transcription activator activity 1.36535925881104 bayes_pls_golite062009
transcription factor binding 1.05399367242529 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.7265140277161 bayes_pls_golite062009
chromatin binding 0.572427333286789 bayes_pls_golite062009
transcription cofactor activity 0.49703800163515 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle