| Protein: | E2F8 |
| Organism: | Homo sapiens |
| Length: | 867 amino acids |
| Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for E2F8.
| Description | E-value | Query Range |
Subject Range |
|
|
8.0E-66 | [1..867] | [1..867] |
|
|
7.0E-64 | [1..867] | [1..867] |
|
|
2.0E-60 | [1..867] | [1..860] |
|
|
4.0E-60 | [1..867] | [1..864] |
|
|
2.0E-59 | [1..867] | [1..877] |
|
|
1.0E-58 | [3..863] | [747..1611] |
|
|
5.0E-50 | [15..860] | [723..1569] |
|
|
5.0E-50 | [14..862] | [448..1294] |
|
Region A: Residues: [1-83] |
1 11 21 31 41 51
| | | | | |
1 MENEKENLFC EPHKRGLMKT PLKESTTANI VLAEIQPDFG PLTTPTKPKE GSQGEPWTPT 60
61 ANLKMLISAV SPEIRNRDQK RGL
|
| Detection Method: |  |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [84-228] |
1 11 21 31 41 51
| | | | | |
1 FDNRSGLPEA KDCIHEHLSG DEFEKSQPSR KEKSLGLLCH KFLARYPNYP NPAVNNDICL 60
61 DEVAEELNVE RRRIYDIVNV LESLHMVSRL AKNRYTWHGR HNLNKTLGTL KSIGEENKYA 120
121 EQIMMIKKKE YEQEFDFIKS YSIED
|
| Detection Method: | |
| Confidence: | 13.69897 |
| Match: | 1cf7A |
| Description: | Cell cycle transcription factor E2F-4 |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| transcription regulator activity | 5.55329976718261 | bayes_pls_golite062009 |
| DNA binding | 5.08959163553491 | bayes_pls_golite062009 |
| nucleic acid binding | 4.69183445184264 | bayes_pls_golite062009 |
| transcription factor activity | 4.33152142980289 | bayes_pls_golite062009 |
| binding | 3.52874320222492 | bayes_pls_golite062009 |
| sequence-specific DNA binding | 2.48053910222825 | bayes_pls_golite062009 |
| transcription activator activity | 2.37668609508629 | bayes_pls_golite062009 |
| transcription repressor activity | 2.22485867684613 | bayes_pls_golite062009 |
| RNA polymerase II transcription factor activity | 1.70025468248325 | bayes_pls_golite062009 |
| transcription factor binding | 0.85714789329232 | bayes_pls_golite062009 |
| protein binding | 0.753698599635855 | bayes_pls_golite062009 |
| specific RNA polymerase II transcription factor activity | 0.0856082199488197 | bayes_pls_golite062009 |
| specific transcriptional repressor activity | 0.0565989703351002 | bayes_pls_golite062009 |
|
Region A: Residues: [229-349] |
1 11 21 31 41 51
| | | | | |
1 HIIKSNTGPN GHPDMCFVEL PGVEFRAASV NSRKDKSLRV MSQKFVMLFL VSTPQIVSLE 60
61 VAAKILIGED HVEDLDKSKF KTKIRRLYDI ANVLSSLDLI KKVHVTEERG RKPAFKWTGP 120
121 E
|
| Detection Method: | |
| Confidence: | 2.38 |
| Match: | 1cf7A |
| Description: | Cell cycle transcription factor E2F-4 |
| Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| transcription regulator activity | 5.23858959608048 | bayes_pls_golite062009 |
| DNA binding | 4.78517210147551 | bayes_pls_golite062009 |
| nucleic acid binding | 4.41560500044233 | bayes_pls_golite062009 |
| transcription factor activity | 4.02736190679869 | bayes_pls_golite062009 |
| binding | 3.37660003833383 | bayes_pls_golite062009 |
| sequence-specific DNA binding | 2.21432668306508 | bayes_pls_golite062009 |
| transcription activator activity | 2.13702350917359 | bayes_pls_golite062009 |
| transcription repressor activity | 1.9708626903609 | bayes_pls_golite062009 |
| RNA polymerase II transcription factor activity | 1.50332889556988 | bayes_pls_golite062009 |
| transcription factor binding | 0.752335897765285 | bayes_pls_golite062009 |
| protein binding | 0.726445167461826 | bayes_pls_golite062009 |
|
Region A: Residues: [350-441] |
1 11 21 31 41 51
| | | | | |
1 ISPNTSGSSP VIHFTPSDLE VRRSSKENCA KNLFSTRGKP NFTRHPSLIK LVKSIESDRR 60
61 KINSAPSSPI KTNKAESSQN SAPFPSKMAQ LA
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [442-546] |
1 11 21 31 41 51
| | | | | |
1 AICKMQLEEQ SSESRQKVKV QLARSGPCKP VAPLDPPVNA EMELTAPSLI QPLGMVPLIP 60
61 SPLSSAVPLI LPQAPSGPSY AIYLQPTQAH QSVTPPQGLS PTVCT
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [547-634] |
1 11 21 31 41 51
| | | | | |
1 THSSKATGSK DSTDATTEKA ANDTSKASAS TRPGSLLPAP ERQGAKSRTR EPAGERGSKR 60
61 ASMLEDSGSK KKFKEDLKGL ENVSATLF
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [635-867] |
1 11 21 31 41 51
| | | | | |
1 PSGYLIPLTQ CSSLGAESIL SGKENSSALS PNHRIYSSPI AGVIPVTSSE LTAVNFPSFH 60
61 VTPLKLMVSP TSVAAVPVGN SPALASSHPV PIQNPSSAIV NFTLQHLGLI SPNVQLSASP 120
121 GSGIVPVSPR IESVNVAPEN AGTQQGRATN YDSPVPGQSQ PNGQSVAVTG AQQPVPVTPK 180
181 GSQLVAESFF RTPGGPTKPT SSSCMDFEGA NKTSLGTLFV PQRKLEVSTE DVH
|
| Detection Method: | |
Shown below is our most confident prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
