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View Structure Prediction Details

Protein: XPNPEP3
Organism: Homo sapiens
Length: 507 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for XPNPEP3.

Description E-value Query
Range
Subject
Range
gi|114686551 - gi|114686551|ref|XP_515152.2| PREDICTED: hypothetical protein isoform 3 [Pan troglodytes]
0.0 [1..507] [1..507]
gi|48146909 - gi|48146909|emb|CAG33677.1| LOC63929 [Homo sapiens]
0.0 [1..507] [1..507]
XPP3_PONAB - Probable Xaa-Pro aminopeptidase 3 OS=Pongo abelii GN=XPNPEP3 PE=2 SV=1
XPP3_PONPY - Putative Xaa-Pro aminopeptidase 3 - Pongo pygmaeus (Orangutan)
0.0 [1..507] [1..507]
gi|73969474 - gi|73969474|ref|XP_538358.2| PREDICTED: similar to CG9581-PA [Canis familiaris]
0.0 [1..507] [1..507]
gi|109481041, gi... - gi|194474100|ref|NP_001124054.1| X-prolyl aminopeptidase (aminopeptidase P) 3, putative [Rattus norv...
0.0 [4..507] [4..506]
gi|67972222 - gi|67972222|dbj|BAE02453.1| unnamed protein product [Macaca fascicularis]
0.0 [24..507] [1..484]
gi|76617043 - gi|76617043|ref|XP_585578.2| PREDICTED: hypothetical protein [Bos taurus]
0.0 [19..507] [21..509]
gi|50728694 - gi|50728694|ref|XP_416240.1| PREDICTED: hypothetical protein [Gallus gallus]
0.0 [12..507] [3..502]
gi|158253582, gi... - gi|68357630|ref|XP_690722.1| PREDICTED: hypothetical protein isoform 1 [Danio rerio], gi|158253582|g...
0.0 [5..506] [3..508]

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Predicted Domain #1
Region A:
Residues: [1-65]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPWLLSAPKL VPAVANVRGL SGCMLCSQRR YSLQPVPERR IPNRYLGQPS PFTHPHLLRP  60
   61 GEVTP

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [66-507]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GLSQVEYALR RHKLMSLIQK EAQGQSGTDQ TVVVLSNPTY YMSNDIPYTF HQDNNFLYLC  60
   61 GFQEPDSILV LQSLPGKQLP SHKAILFVPR RDPSRELWDG PRSGTDGAIA LTGVDEAYTL 120
  121 EEFQHLLPKM KAETNMVWYD WMRPSHAQLH SDYMQPLTEA KAKSKNKVRG VQQLIQRLRL 180
  181 IKSPAEIERM QIAGKLTSQA FIETMFTSKA PVEEAFLYAK FEFECRARGA DILAYPPVVA 240
  241 GGNRSNTLHY VKNNQLIKDG EMVLLDGGCE SSCYVSDITR TWPVNGRFTA PQAELYEAVL 300
  301 EIQRDCLALC FPGTSLENIY SMMLTLIGQK LKDLGIMKNI KENNAFKAAR KYCPHHVGHY 360
  361 LGMDVHDTPD MPRSLPLQPG MVITIEPGIY IPEDDKDAPE KFRGLGVRIE DDVVVTQDSP 420
  421 LILSADCPKE MNDIEQICSQ AS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 93.69897
Match: 1a16A
Description: AMINOPEPTIDASE P FROM E. COLI WITH THE INHIBITOR PRO-LEU
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
peptidase activity 2.60615909541559 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 2.18503136472662 bayes_pls_golite062009
metallopeptidase activity 1.75829852010848 bayes_pls_golite062009
hydrolase activity 1.43646476372001 bayes_pls_golite062009
aminopeptidase activity 0.89399203910285 bayes_pls_golite062009
binding 0.762408229471586 bayes_pls_golite062009
exopeptidase activity 0.762255574851485 bayes_pls_golite062009
nucleic acid binding 0.352607952828331 bayes_pls_golite062009
catalytic activity 0.148551873544128 bayes_pls_golite062009
transcription regulator activity 0.0346092896934742 bayes_pls_golite062009
DNA binding 0.0315289262145955 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle