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View Structure Prediction Details

Protein: gi|31563344, gi|...
Organism: Homo sapiens
Length: 505 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|31563344, gi|....

Description E-value Query
Range		 Subject
Range
gi|109101202 - gi|109101202|ref|XP_001107628.1| PREDICTED: paired box gene 3 (Waardenburg syndrome 1) isoform 7 [Ma...
 1.0E-72 [1..488] [1..488]
gi|109477586, gi... - gi|109477586|ref|XP_001071787.1| PREDICTED: similar to paired box gene 7 [Rattus norvegicus], gi|109...
 4.0E-71 [1..484] [1..476]
gi|74180492 - gi|74180492|dbj|BAE34184.1| unnamed protein product [Mus musculus]
 4.0E-71 [1..484] [1..484]
gi|114583573 - gi|114583573|ref|XP_001165215.1| PREDICTED: paired box gene 3 isoform 2 [Pan troglodytes]
 8.0E-71 [1..484] [1..481]
ENSMMUT000000444... - null, null
gi|114583569 - gi|114583569|ref|XP_001165426.1| PREDICTED: paired box gene 3 isoform 7 [Pan troglodytes]
gi|72533682, gi|... - gi|72533682|gb|AAI01302.1| Paired box 3 [Homo sapiens], gi|31563342|ref|NP_852123.1| paired box 3 is...
 3.0E-70 [1..484] [1..484]

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Predicted Domain #1
Region A:
Residues: [1-189] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTLAGAVPR MMRPGPGQNY PRSGFPLEVS TPLGQGRVNQ LGGVFINGRP LPNHIRHKIV  60
   61 EMAHHGIRPC VISRQLRVSH GCVSKILCRY QETGSIRPGA IGGSKPKQVT TPDVEKKIEE 120
  121 YKRENPGMFS WEIRDKLLKD AVCDRNTVPS VSSISRILRS KFGKGEEEEA DLERKEAEES 180
  181 EKKAKHSID

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 37.0
Match: 1k78A
Description: Pax-5
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.51452285155271 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
transcription repressor activity 3.55154985983449 bayes_pls_golite062009
sequence-specific DNA binding 3.5139760613123 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.16896789933192 bayes_pls_golite062009
transcription activator activity 3.10621734076555 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
protein binding 1.88087411289001 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.73068440195944 bayes_pls_golite062009
chromatin binding 1.68956710349366 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.62096064323298 bayes_pls_golite062009
transcription corepressor activity 1.49423102874486 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
transcription coactivator activity 0.2679415219517 bayes_pls_golite062009
protein deacetylase activity 0.0943601066056998 bayes_pls_golite062009
histone deacetylase activity 0.0802156998596484 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [190-289] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GILSERASAP QSDEGSDIDS EPDLPLKRKQ RRSRTTFTAE QLEELERAFE RTHYPDIYTR  60
   61 EELAQRAKLT EARVQVWFSN RRARWRKQAG ANQLMAFNHL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 17.0
Match: 2cueA
Description: Solution structure of the homeobox domain of the human paired box protein Pax-6
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.51452285155271 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
transcription repressor activity 3.55154985983449 bayes_pls_golite062009
sequence-specific DNA binding 3.5139760613123 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.16896789933192 bayes_pls_golite062009
transcription activator activity 3.10621734076555 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
protein binding 1.88087411289001 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.73068440195944 bayes_pls_golite062009
chromatin binding 1.68956710349366 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.62096064323298 bayes_pls_golite062009
transcription corepressor activity 1.49423102874486 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
transcription coactivator activity 0.2679415219517 bayes_pls_golite062009
protein deacetylase activity 0.0943601066056998 bayes_pls_golite062009
histone deacetylase activity 0.0802156998596484 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [290-505] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IPGGFPPTAM PTLPTYQLSE TSYQPTSIPQ AVSDPSSTVH RPQPLPPSTV HQSTIPSNPD  60
   61 SSSAYCLPST RHGFSSYTDS FVPPSGPSNP MNPTIGNGLS PQVMGLLTNH GGVPHQPQTD 120
  121 YALSPLTGGL EPTTTVSASC SQRLDHMKSL DSLPTSQSYC PPTYSTTGYS MDPVTGYQYG 180
  181 QYGQSAFHYL KPDIAWFQIL LNTFDKSSGE EEDLEQ

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle