| Protein: | gi|119629550, gi... |
| Organism: | Homo sapiens |
| Length: | 782 amino acids |
| Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|119629550, gi....
| Description | E-value | Query Range |
Subject Range |
|
|
0.0 | [1..782] | [31..812] |
|
|
0.0 | [1..782] | [28..809] |
|
|
0.0 | [2..771] | [95..861] |
|
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0.0 | [1..782] | [1..777] |
|
Region A: Residues: [1-94] |
1 11 21 31 41 51
| | | | | |
1 MNSAEQTVTW LITLGVLESP KKTISDPEGF LQASLKDGVV LCRLLERLLP GTIEKVYPEP 60
61 RSESECLSNI REFLRGCGAS LRLETFDAND LYQG
|
| Detection Method: |  |
| Confidence: | 18.09691 |
| Match: | 1wyrA |
| Description: | Solution structure of the CH domain of human Rho guanine nucleotide exchange factor 6 |
Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [95-153] |
1 11 21 31 41 51
| | | | | |
1 QNFNKVLSSL VTLNKVTADI GLGSDSVCAR PSSHRIKSFD SLGSQSLHTR TSKLFQGQY
|
| Detection Method: | |
| Confidence: | 0.987 |
| Match: | 1wynA |
| Description: | Solution structure of the CH domain of human calponin-2 |
Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [154-224] |
1 11 21 31 41 51
| | | | | |
1 RSLDMTDNSN NQLVVRAKFN FQQTNEDELS FSKGDVIHVT RVEEGGWWEG TLNGRTGWFP 60
61 SNYVREVKAS E
|
| Detection Method: | |
| Confidence: | 5.0 |
| Match: | 1zsgA |
| Description: | beta PIX-SH3 complexed with an atypical peptide from alpha-PAK |
Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [225-319] |
1 11 21 31 41 51
| | | | | |
1 KPVSPKSGTL KSPPKGFDTT AINKSYYNVV LQNILETENE YSKELQTVLS TYLRPLQTSE 60
61 KLSSANISYL MGNLEEICSF QQMLVQSLEE CTKLP
|
| Detection Method: | |
| Confidence: | 24.69897 |
| Match: | 1by1A |
| Description: | beta-pix |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| GTPase regulator activity | 5.11074603459714 | bayes_pls_golite062009 |
| nucleoside-triphosphatase regulator activity | 5.08847923392129 | bayes_pls_golite062009 |
| guanyl-nucleotide exchange factor activity | 4.86840565991411 | bayes_pls_golite062009 |
| small GTPase regulator activity | 4.48792387237937 | bayes_pls_golite062009 |
| enzyme regulator activity | 4.3439350617225 | bayes_pls_golite062009 |
| Rho guanyl-nucleotide exchange factor activity | 4.34078803610551 | bayes_pls_golite062009 |
| Ras guanyl-nucleotide exchange factor activity | 4.20362774065877 | bayes_pls_golite062009 |
| binding | 2.72918942472263 | bayes_pls_golite062009 |
| protein binding | 1.55620082928053 | bayes_pls_golite062009 |
| signal transducer activity | 1.38049306661118 | bayes_pls_golite062009 |
| molecular transducer activity | 1.38049306661118 | bayes_pls_golite062009 |
| GTPase activator activity | 0.752349454878473 | bayes_pls_golite062009 |
| receptor binding | 0.540147469472769 | bayes_pls_golite062009 |
| transcription regulator activity | 0.535089791137297 | bayes_pls_golite062009 |
| enzyme activator activity | 0.453716946272335 | bayes_pls_golite062009 |
| Ras GTPase activator activity | 0.451744196693003 | bayes_pls_golite062009 |
| small GTPase binding | 0.40881922277547 | bayes_pls_golite062009 |
| nucleic acid binding | 0.401233613072731 | bayes_pls_golite062009 |
| GTPase binding | 0.38955577404416 | bayes_pls_golite062009 |
| DNA binding | 0.313566245805362 | bayes_pls_golite062009 |
| cytoskeletal protein binding | 0.27856999050234 | bayes_pls_golite062009 |
| Rho GTPase activator activity | 0.211048635764309 | bayes_pls_golite062009 |
|
Region A: Residues: [320-446] |
1 11 21 31 41 51
| | | | | |
1 EAQQRVGGCF LNLMPQMKTL YLTYCANHPS AVNVLTEHSE ELGEFMETKG ASSPGILVLT 60
61 TGLSKPFMRL DKYPTLLKEL ERHMEDYHTD RQDIQKSMAA FKNLSAQCQE VRKRKELELQ 120
121 ILTEAIR
|
| Detection Method: | |
| Confidence: | 11.0 |
| Match: | 2bdfA |
| Description: | No description for 2bdfA was found. |
|
Region A: Residues: [447-564] |
1 11 21 31 41 51
| | | | | |
1 NWEGDDIKTL GNVTYMSQVL IQCAGSEEKN ERYLLLFPNV LLMLSASPRM SGFIYQGKLP 60
61 TTGMTITKLE DSENHRNAFE ISGSMIERIL VSCNNQQDLQ EWVEHLQKQT KVTSVGNP
|
| Detection Method: | |
| Confidence: | 12.522879 |
| Match: | 1v61A |
| Description: | Solution Structure of the Pleckstrin Homology Domain of alpha-Pix |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| binding | 3.29080729281876 | bayes_pls_golite062009 |
| protein binding | 2.12168271674167 | bayes_pls_golite062009 |
| GTPase regulator activity | 1.66986263418539 | bayes_pls_golite062009 |
| nucleoside-triphosphatase regulator activity | 1.64990514605397 | bayes_pls_golite062009 |
| signal transducer activity | 1.55319485371003 | bayes_pls_golite062009 |
| molecular transducer activity | 1.55319485371003 | bayes_pls_golite062009 |
| receptor signaling protein activity | 1.37575288352057 | bayes_pls_golite062009 |
| small GTPase regulator activity | 1.2550809703725 | bayes_pls_golite062009 |
| enzyme regulator activity | 1.25381967078645 | bayes_pls_golite062009 |
| profilin binding | 1.13790597338922 | bayes_pls_golite062009 |
| beta-amyloid binding | 1.05609939813042 | bayes_pls_golite062009 |
| protein domain specific binding | 0.90578029954417 | bayes_pls_golite062009 |
| transporter activity | 0.882299675921716 | bayes_pls_golite062009 |
| small GTPase binding | 0.8507658747425 | bayes_pls_golite062009 |
| GTPase binding | 0.82889812790119 | bayes_pls_golite062009 |
| guanyl-nucleotide exchange factor activity | 0.745321902095093 | bayes_pls_golite062009 |
| cytoskeletal protein binding | 0.570303292760019 | bayes_pls_golite062009 |
| receptor binding | 0.50127063593663 | bayes_pls_golite062009 |
| substrate-specific transporter activity | 0.47853225730469 | bayes_pls_golite062009 |
| receptor activity | 0.353510125274044 | bayes_pls_golite062009 |
| transcription regulator activity | 0.324566338715835 | bayes_pls_golite062009 |
| actin binding | 0.3076498786796 | bayes_pls_golite062009 |
| transmembrane receptor activity | 0.207829786337892 | bayes_pls_golite062009 |
| transmembrane receptor protein tyrosine kinase signaling protein activity | 0.13700176999256 | bayes_pls_golite062009 |
| DNA binding | 0.136435190086451 | bayes_pls_golite062009 |
| nucleic acid binding | 0.118897432176337 | bayes_pls_golite062009 |
|
Region A: Residues: [565-658] |
1 11 21 31 41 51
| | | | | |
1 TIKPHSVPSH TLPSHPVTPS SKHADSKPAP LTPAYHTLPH PSHHGTPHTT INWGPLEPPK 60
61 TPKPWSLSCL RPAPPLRPSA ALCYKEDLSK SPKT
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
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Region A: Residues: [659-782] |
1 11 21 31 41 51
| | | | | |
1 MKKLLPKRKP ERKPSDEEFA SRKSTAALEE DAQILKVIEA YCTSAKTRQT LNSTWQGTDL 60
61 MHNHVLADDD QPSLDSLGRR SSLSRLEPSD LSEDSDYDSI WTAHSYRMGS TSRKSCCSYI 120
121 SHQN
|
| Detection Method: | |
| Confidence: | 17.0 |
| Match: | 1wlpB |
| Description: | Solution Structure Of The P22Phox-P47Phox Complex |
Matching Structure (courtesy of the PDB): |
|
