YRC Public Data Repository - Protein Structure Prediction

Protein:	YBAL_ECOLI
Organism:	Escherichia coli
Length:	558 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YBAL_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|90578110, gi\|... - gi\|90578110\|ref\|ZP_01233921.1\| glutathione-regulated potassium-efflux system protein KefC [Vibrio an...	312.0	[0..7]	[554..4]
gi\|89048555, gi\|... - gi\|89075692\|ref\|ZP_01162087.1\| glutathione-regulated potassium-efflux system protein KefC [Photobact...	312.0	[0..7]	[554..4]
gi\|86144348, gi\|... - gi\|86144348\|ref\|ZP_01062680.1\| glutathione-regulated potassium-efflux system protein KefC [Vibrio sp...	311.0	[0..7]	[552..4]
gi\|84390442, gi\|... - gi\|84390442\|ref\|ZP_00991453.1\| glutathione-regulated potassium-efflux system protein KefC [Vibrio sp...	310.0	[0..7]	[552..4]
gi\|115511461, gi... - gi\|117622337\|ref\|YP_851250.1\| glutathione-regulated potassium-efflux system protein KefC [Escherichi...	308.0	[0..4]	[553..26]
gi\|28900319, gi\|... - gi\|28900319\|ref\|NP_799974.1\| putative TrkA family protein [Vibrio parahaemolyticus RIMD 2210633], gi... gi\|28808630 - gi\|28808630\|dbj\|BAC61807.1\| putative TrkA family protein [Vibrio parahaemolyticus RIMD 2210633]	303.0	[0..7]	[554..4]
KEFC_SHISS - Glutathione-regulated potassium-efflux system protein KefC OS=Shigella sonnei (strain Ss046) GN=kefC...	303.0	[0..4]	[553..2]
gi\|253976282, gi... - gi\|254286975\|ref\|YP_003052723.1\| glutathione-regulated potassium-efflux system protein [Escherichia ... gi\|251783613, gi... - gi\|251783613\|ref\|YP_002997917.1\| hypothetical protein B21_00050 [Escherichia coli BL21], gi\|24237588... gi\|253972073, gi... - gi\|254160172\|ref\|YP_003043280.1\| glutathione-regulated potassium-efflux system protein [Escherichia ... gi\|226840570, gi... - gi\|254037464\|ref\|ZP_04871541.1\| potassium:proton antiporter [Escherichia sp. 1_1_43], gi\|226840570\|g... KEFC_ECO8A - Glutathione-regulated potassium-efflux system protein KefC OS=Escherichia coli O8 (strain IAI1) GN=k... KEFC_ECOSE - Glutathione-regulated potassium-efflux system protein KefC OS=Escherichia coli (strain SE11) GN=kefC... KEFC_ECOHS - Glutathione-regulated potassium-efflux system protein KefC OS=Escherichia coli O9:H4 (strain HS) GN=... KEFC_SHIBS - Glutathione-regulated potassium-efflux system protein KefC OS=Shigella boydii serotype 4 (strain Sb2... gi\|83584908, gi\|... - gi\|83584908\|ref\|ZP_00923565.1\| COG0475: Kef-type K+ transport systems, membrane components [Escheric... KEFC_SHIB3 - Glutathione-regulated potassium-efflux system protein KefC OS=Shigella boydii serotype 18 (strain CD...	303.0	[0..4]	[553..2]
gi\|75255702, gi\|... - gi\|75255702\|ref\|ZP_00727468.1\| COG0475: Kef-type K+ transport systems, membrane components [Escheric...	303.0	[0..4]	[553..2]
gi\|59713443, gi\|... - gi\|59713443\|ref\|YP_206218.1\| glutathione-regulated potassium-efflux system protein KefC [Vibrio fisc...	303.0	[0..7]	[554..4]

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Predicted Domain #1

Region A:
Residues: [1-178]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHHATPLITT IVGGLVLAFI LGMLANKLRI SPLVGYLLAG VLAGPFTPGF VADTKLAPEL  60
   61 AELGVILLMF GVGLHFSLKD LMAVKAIAIP GAIAQIAVAT LLGMALSAVL GWSLMTGIVF 120
  121 GLCLSTASTV VLLRALEERQ LIDSQRGQIA IGWLIVEDLV MVLTLVLLPA VAGMMEQG

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [179-287]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DVGFATLAVD MGITIGKVIA FIAIMMLVGR RLVPWIMARS AATGSRELFT LSVLALALGV  60
   61 AFGAVELFDV SFALGAFFAG MVLNESELSH RAAHDTLPLR DAFAVLFFV

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [288-558]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SVGMLFDPLI LIQQPLAVLA TLAIILFGKS LAAFFLVRLF GHSQRTALTI AASLAQIGEF  60
   61 AFILAGLGMA LNLLPQAGQN LVLAGAILSI MLNPVLFALL EKYLAKTETL EEQTLEEAIE 120
  121 EEKQIPVDIC NHALLVGYGR VGSLLGEKLL ASDIPLVVIE TSRTRVDELR ERGVRAVLGN 180
  181 AANEEIMQLA HLECAKWLIL TIPNGYEAGE IVASARAKNP DIEIIARAHY DDEVAYITER 240
  241 GANQVVMGER EIARTMLELL ETPPAGEVVT G

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	12.045757
Match:	1lnqA
Description:	Potassium channel-related protein MthK
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
potassium channel activity	7.45561375804942	bayes_pls_golite062009
voltage-gated potassium channel activity	7.44058571110681	bayes_pls_golite062009
voltage-gated cation channel activity	7.3386698127529	bayes_pls_golite062009
voltage-gated ion channel activity	7.16469552587678	bayes_pls_golite062009
voltage-gated channel activity	7.14063840809955	bayes_pls_golite062009
metal ion transmembrane transporter activity	5.93188092092616	bayes_pls_golite062009
cation channel activity	5.49362429102263	bayes_pls_golite062009
cation transmembrane transporter activity	5.13805155650973	bayes_pls_golite062009
inward rectifier potassium channel activity	5.0997110076666	bayes_pls_golite062009
ion transmembrane transporter activity	5.04374327766634	bayes_pls_golite062009
ion channel activity	4.88752793243149	bayes_pls_golite062009
gated channel activity	4.87650815860853	bayes_pls_golite062009
substrate-specific channel activity	4.76774891791883	bayes_pls_golite062009
channel activity	4.7460548761362	bayes_pls_golite062009
passive transmembrane transporter activity	4.7460548761362	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	4.64120459994573	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	3.88411419181428	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	2.96809690970616	bayes_pls_golite062009
ligand-gated ion channel activity	2.94075163359893	bayes_pls_golite062009
ligand-gated channel activity	2.94075163359893	bayes_pls_golite062009
transporter activity	2.93091397928047	bayes_pls_golite062009
transmembrane transporter activity	2.82224868778929	bayes_pls_golite062009
substrate-specific transporter activity	2.79688978937497	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	2.13014428099026	bayes_pls_golite062009
potassium ion transmembrane transporter activity	1.34449386905866	bayes_pls_golite062009
active transmembrane transporter activity	0.239024094835991	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: