YRC Public Data Repository - Protein Structure Prediction

Protein:	SYL_ECOLI
Organism:	Escherichia coli
Length:	860 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SYL_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|1778560 - gi\|1778560\|gb\|AAB40843.1\| leucine tRNA synthetase [Escherichia coli]	803.0	[0..1]	[860..48]
gi\|75237598 - gi\|75237598\|ref\|ZP_00721629.1\| COG0495: Leucyl-tRNA synthetase [Escherichia coli F11] gi\|26107022, gi\|... - gi\|26246623\|ref\|NP_752663.1\| leucyl-tRNA synthetase [Escherichia coli CFT073], gi\|26107022\|gb\|AAN792... gi\|227838464, gi... - gi\|227884378\|ref\|ZP_04002183.1\| leucyl-tRNA synthetase [Escherichia coli 83972], gi\|227838464\|gb\|EEJ...	802.0	[0..1]	[860..48]
gi\|117622858, gi... - gi\|117622858\|ref\|YP_851771.1\| leucyl-tRNA synthetase [Escherichia coli APEC O1], gi\|115511982\|gb\|ABJ... gi\|91209690, gi\|... - gi\|91209690\|ref\|YP_539676.1\| leucyl-tRNA synthetase [Escherichia coli UTI89], gi\|91071264\|gb\|ABE0614... gi\|226898594, gi... - gi\|237707384\|ref\|ZP_04537865.1\| leucyl-tRNA synthetase [Escherichia sp. 3_2_53FAA], gi\|226898594\|gb\|...	802.0	[0..1]	[860..48]
gi\|75511287 - gi\|75511287\|ref\|ZP_00733981.1\| COG0495: Leucyl-tRNA synthetase [Escherichia coli 53638]	798.0	[0..1]	[860..9]
gi\|30062169, gi\|... - gi\|30062169\|ref\|NP_836340.1\| leucyl-tRNA synthetase [Shigella flexneri 2a str. 2457T], gi\|30040414\|g... SYL_SHIFL - Leucine--tRNA ligase OS=Shigella flexneri GN=leuS PE=3 SV=2 gi\|56479706, gi\|... - gi\|56479706\|ref\|NP_706568.2\| leucyl-tRNA synthetase [Shigella flexneri 2a str. 301], gi\|56383257\|gb\|...	797.0	[0..1]	[860..1]
gi\|110804709, gi... - gi\|110804709\|ref\|YP_688229.1\| leucyl-tRNA synthetase [Shigella flexneri 5 str. 8401], gi\|110614257\|g...	797.0	[0..1]	[860..32]
SYL_SHIDS - Leucine--tRNA ligase OS=Shigella dysenteriae serotype 1 (strain Sd197) GN=leuS PE=3 SV=1	797.0	[0..1]	[860..1]
SYL_ECOSE - Leucine--tRNA ligase OS=Escherichia coli (strain SE11) GN=leuS PE=3 SV=1 gi\|75228099, gi\|... - gi\|75228099\|ref\|ZP_00714770.1\| COG0495: Leucyl-tRNA synthetase [Escherichia coli B7A], gi\|191168680\|...	797.0	[0..1]	[860..1]
gi\|62126881, gi\|... - gi\|62179248\|ref\|YP_215665.1\| leucyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar Cho...	796.0	[0..1]	[860..32]
gi\|83584761, gi\|... - gi\|83584761\|ref\|ZP_00923424.1\| COG0495: Leucyl-tRNA synthetase [Escherichia coli 101-1], gi\|19443988... gi\|254287512, gi... - gi\|254287512\|ref\|YP_003053260.1\| leucyl-tRNA synthetase [Escherichia coli BL21(DE3)], gi\|253976819\|g... gi\|251784144, gi... - gi\|251784144\|ref\|YP_002998448.1\| hypothetical protein B21_00600 [Escherichia coli BL21], gi\|24237641... gi\|254160724, gi... - gi\|254160724\|ref\|YP_003043832.1\| leucyl-tRNA synthetase [Escherichia coli B str. REL606], gi\|2539726...	796.0	[0..1]	[860..1]

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Predicted Domain #1

Region A:
Residues: [1-860]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQEQYRPEEI ESKVQLHWDE KRTFEVTEDE SKEKYYCLSM LPYPSGRLHM GHVRNYTIGD  60
   61 VIARYQRMLG KNVLQPIGWD AFGLPAEGAA VKNNTAPAPW TYDNIAYMKN QLKMLGFGYD 120
  121 WSRELATCTP EYYRWEQKFF TELYKKGLVY KKTSAVNWCP NDQTVLANEQ VIDGCCWRCD 180
  181 TKVERKEIPQ WFIKITAYAD ELLNDLDKLD HWPDTVKTMQ RNWIGRSEGV EITFNVNDYD 240
  241 NTLTVYTTRP DTFMGCTYLA VAAGHPLAQK AAENNPELAA FIDECRNTKV AEAEMATMEK 300
  301 KGVDTGFKAV HPLTGEEIPV WAANFVLMEY GTGAVMAVPG HDQRDYEFAS KYGLNIKPVI 360
  361 LAADGSEPDL SQQALTEKGV LFNSGEFNGL DHEAAFNAIA DKLTAMGVGE RKVNYRLRDW 420
  421 GVSRQRYWGA PIPMVTLEDG TVMPTPDDQL PVILPEDVVM DGITSPIKAD PEWAKTTVNG 480
  481 MPALRETDTF DTFMESSWYY ARYTCPQYKE GMLDSEAANY WLPVDIYIGG IEHAIMHLLY 540
  541 FRFFHKLMRD AGMVNSDEPA KQLLCQGMVL ADAFYYVGEN GERNWVSPVD AIVERDEKGR 600
  601 IVKAKDAAGH ELVYTGMSKM SKSKNNGIDP QVMVERYGAD TVRLFMMFAS PADMTLEWQE 660
  661 SGVEGANRFL KRVWKLVYEH TAKGDVAALN VDALTENQKA LRRDVHKTIA KVTDDIGRRQ 720
  721 TFNTAIAAIM ELMNKLAKAP TDGEQDRALM QEALLAVVRM LNPFTPHICF TLWQELKGEG 780
  781 DIDNAPWPVA DEKAMVEDST LVVVQVNGKV RAKITVPVDA TEEQVRERAG QEHLVAKYLD 840
  841 GVTVRKVIYV PGKLLNLVVG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1000.0
Match:	1h3nA
Description:	Leucyl-tRNA synthetase (LeuRS)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
leucine-tRNA ligase activity	7.22072912979813	bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds	6.4693800838561	bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds	6.4693800838561	bayes_pls_golite062009
aminoacyl-tRNA ligase activity	6.4443227172352	bayes_pls_golite062009
ligase activity	5.65872852832815	bayes_pls_golite062009
valine-tRNA ligase activity	2.9249205353164	bayes_pls_golite062009
catalytic activity	2.74718220535323	bayes_pls_golite062009
isoleucine-tRNA ligase activity	1.84298837861364	bayes_pls_golite062009
glutamate-tRNA ligase activity	1.69027214128932	bayes_pls_golite062009
methionine-tRNA ligase activity	1.63830426964771	bayes_pls_golite062009
tyrosine-tRNA ligase activity	1.51606758855865	bayes_pls_golite062009
tryptophan-tRNA ligase activity	1.33068350385001	bayes_pls_golite062009
cysteine-tRNA ligase activity	1.02341432978103	bayes_pls_golite062009
arginine-tRNA ligase activity	0.92755725518345	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: