| Protein: | SIRT4 |
| Organism: | Homo sapiens |
| Length: | 314 amino acids |
| Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SIRT4.
| Description | E-value | Query Range |
Subject Range |
|
|
4.0E-98 | [1..314] | [1..314] |
|
|
2.0E-95 | [1..314] | [1..326] |
|
|
1.0E-92 | [7..313] | [89..395] |
|
|
3.0E-91 | [1..313] | [1..314] |
|
|
2.0E-87 | [21..313] | [2..294] |
|
|
2.0E-87 | [7..313] | [5..311] |
|
Region A: Residues: [1-314] |
1 11 21 31 41 51
| | | | | |
1 MKMSFALTFR SAKGRWIANP SQPCSKASIG LFVPASPPLD PEKVKELQRF ITLSKRLLVM 60
61 TGAGISTESG IPDYRSEKVG LYARTDRRPI QHGDFVRSAP IRQRYWARNF VGWPQFSSHQ 120
121 PNPAHWALST WEKLGKLYWL VTQNVDALHT KAGSRRLTEL HGCMDRVLCL DCGEQTPRGV 180
181 LQERFQVLNP TWSAEAHGLA PDGDVFLSEE QVRSFQVPTC VQCGGHLKPD VVFFGDTVNP 240
241 DKVDFVHKRV KEADSLLVVG SSLQVYSGYR FILTAWEKKL PIAILNIGPT RSDDLACLKL 300
301 NSRCGELLPL IDPC
|
| Detection Method: |  |
| Confidence: | 74.522879 |
| Match: | 1ma3A |
| Description: | AF0112, Sir2 homolog (Sir2-AF2) |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| NAD-dependent protein deacetylase activity | 5.14934829690585 | bayes_pls_golite062009 |
| NAD-dependent histone deacetylase activity | 5.14934829690585 | bayes_pls_golite062009 |
| histone deacetylase activity | 4.99253312362199 | bayes_pls_golite062009 |
| protein deacetylase activity | 4.98469537386457 | bayes_pls_golite062009 |
| NAD+ ADP-ribosyltransferase activity | 4.62921662347995 | bayes_pls_golite062009 |
| deacetylase activity | 3.9985462274265 | bayes_pls_golite062009 |
| transcription regulator activity | 2.9155913558118 | bayes_pls_golite062009 |
| DNA binding | 2.43141001866996 | bayes_pls_golite062009 |
| nucleic acid binding | 2.41433477472968 | bayes_pls_golite062009 |
| transcription repressor activity | 2.24657784428979 | bayes_pls_golite062009 |
| binding | 2.06552694538163 | bayes_pls_golite062009 |
| transcription corepressor activity | 1.64212790017753 | bayes_pls_golite062009 |
| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides | 1.38412624618353 | bayes_pls_golite062009 |
| transcription factor activity | 1.30143289828088 | bayes_pls_golite062009 |
| transcription factor binding | 1.14766678956419 | bayes_pls_golite062009 |
| histone binding | 1.08869740692996 | bayes_pls_golite062009 |
| NAD(P)+-protein-arginine ADP-ribosyltransferase activity | 0.963519974868694 | bayes_pls_golite062009 |
| catalytic activity | 0.739210399081789 | bayes_pls_golite062009 |
| substrate-specific transmembrane transporter activity | 0.62029498163975 | bayes_pls_golite062009 |
| inorganic cation transmembrane transporter activity | 0.56000396203236 | bayes_pls_golite062009 |
| transcription cofactor activity | 0.54005617175343 | bayes_pls_golite062009 |
| monovalent inorganic cation transmembrane transporter activity | 0.52020182886741 | bayes_pls_golite062009 |
| protein binding | 0.475479132768057 | bayes_pls_golite062009 |
| hydrogen ion transmembrane transporter activity | 0.47231237137431 | bayes_pls_golite062009 |
| substrate-specific transporter activity | 0.128843577740998 | bayes_pls_golite062009 |
| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds | 0.114062221123972 | bayes_pls_golite062009 |
| hydrolase activity | 0.0875567934348688 | bayes_pls_golite062009 |
