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View Structure Prediction Details

Protein: HAND2_MOUSE
Organism: Mus musculus
Length: 217 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HAND2_MOUSE.

Description E-value Query
Range
Subject
Range
gi|30231224, gi|... - gi|30231224|ref|NP_034532.2| heart and neural crest derivatives expressed transcript 2 [Mus musculus...
7.0E-46 [1..217] [1..217]
HAND2_XENLA - Heart- and neural crest derivatives-expressed protein 2 OS=Xenopus laevis GN=hand2 PE=2 SV=1
3.0E-42 [1..217] [1..210]
gi|109076191 - gi|109076191|ref|XP_001085733.1| PREDICTED: similar to heart and neural crest derivatives expressed ...
5.0E-40 [1..217] [1..186]
gi|68354996, gi|... - gi|68354996|ref|XP_694809.1| PREDICTED: similar to dHAND [Danio rerio], gi|122890476|emb|CAM13338.1|...
8.0E-40 [1..217] [1..205]
HAND2_CHICK - Heart- and neural crest derivatives-expressed protein 2 OS=Gallus gallus GN=HAND2 PE=2 SV=1
4.0E-39 [1..217] [1..216]
gi|72533403 - gi|72533403|gb|AAI01407.1| HAND2 protein [Homo sapiens]
5.0E-38 [1..217] [1..180]

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Predicted Domain #1
Region A:
Residues: [1-91]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLVGGFPHH PVVHHEGYPF AAAAAAAAAA AASRCSHEEN PYFHGWLIGH PEMSPPDYSM  60
   61 ALSYSPEYAS GAAGLDHSHY GGVPPGAGPP G

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [92-217]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LGGPRPVKRR GTANRKERRR TQSINSAFAE LRECIPNVPA DTKLSKIKTL RLATSYIAYL  60
   61 MDLLAKDDQN GEAEAFKAEI KKTDVKEEKR KKELNEILKS TVSSNDKKTK GRTGWPQHVW 120
  121 ALELKQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 18.221849
Match: 1nkpA
Description: Myc prot-oncogene protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.38658950816179 bayes_pls_golite062009
DNA binding 5.18654839258297 bayes_pls_golite062009
nucleic acid binding 5.05768805749761 bayes_pls_golite062009
transcription factor activity 4.78039531631248 bayes_pls_golite062009
transcription activator activity 3.87875547821718 bayes_pls_golite062009
binding 3.81829206350975 bayes_pls_golite062009
sequence-specific DNA binding 3.42035985454056 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.39500382187264 bayes_pls_golite062009
protein binding 2.64975291677725 bayes_pls_golite062009
transcription factor binding 2.61163564741984 bayes_pls_golite062009
transcription repressor activity 2.58751248599889 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 2.42306484786159 bayes_pls_golite062009
transcription corepressor activity 2.03674713048499 bayes_pls_golite062009
promoter binding 1.56457725225443 bayes_pls_golite062009
transcription cofactor activity 1.52770895937238 bayes_pls_golite062009
transcription coactivator activity 1.39260472877067 bayes_pls_golite062009
protein heterodimerization activity 0.53175615551166 bayes_pls_golite062009
structure-specific DNA binding 0.3655541712365 bayes_pls_golite062009
double-stranded DNA binding 0.29436315000437 bayes_pls_golite062009
protein dimerization activity 0.20674648626116 bayes_pls_golite062009

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