YRC Public Data Repository - Protein Structure Prediction

Protein:	FES_ECOLI
Organism:	Escherichia coli
Length:	374 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FES_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|81240010, gi\|... - gi\|82775862\|ref\|YP_402209.1\| enterobactin/ferric enterobactin esterase [Shigella dysenteriae Sd197],...	247.0	[0..1]	[374..1]
gi\|187430423, gi... - gi\|75177513\|ref\|ZP_00697594.1\| COG2382: Enterochelin esterase and related enzymes [Shigella boydii B...	246.0	[0..1]	[374..27]
gi\|81244441, gi\|... - gi\|82543030\|ref\|YP_406977.1\| enterobactin/ferric enterobactin esterase [Shigella boydii Sb227], gi\|8...	246.0	[0..1]	[374..1]
gi\|75189624 - gi\|75189624\|ref\|ZP_00702891.1\| COG2382: Enterochelin esterase and related enzymes [Escherichia coli ... gi\|75229530, gi\|... - gi\|75229530\|ref\|ZP_00716077.1\| COG2382: Enterochelin esterase and related enzymes [Escherichia coli ...	245.0	[0..1]	[374..27]
gi\|169755985, gi... - gi\|170021057\|ref\|YP_001726011.1\| enterobactin/ferric enterobactin esterase [Escherichia coli ATCC 87... EG10299 - enterobactin /ferrienterobactin esterase / Enterochelin esterase gi\|188495431, gi... - gi\|75514679\|ref\|ZP_00736934.1\| COG2382: Enterochelin esterase and related enzymes [Escherichia coli ... gi\|124499379, gi... - gi\|124530216\|ref\|ZP_01700965.1\| putative esterase [Escherichia coli B], gi\|124499379\|gb\|EAY46869.1\| ... EG10299 - enterobactin /ferrienterobactin esterase / Enterochelin esterase gi\|1778501 - gi\|1778501\|gb\|AAB40784.1\| enterochelin esterase [Escherichia coli]	245.0	[0..1]	[374..27]
gi\|13360082, gi\|... - gi\|15829878\|ref\|NP_308651.1\| enterochelin esterase [Escherichia coli O157:H7], gi\|13360082\|dbj\|BAB34... gi\|209777598, gi... - pir\|\|C85557 enterochelin esterase [imported] - Escherichia coli (strain O157:H7, substrain EDL933),... gi\|12513474, gi\|... - gi\|15800299\|ref\|NP_286311.1\| enterobactin/ferric enterobactin esterase [Escherichia coli O157:H7 EDL... gi\|13360082, gi\|... - gi\|15829878\|ref\|NP_308651.1\| enterobactin/ferric enterobactin esterase [Escherichia coli O157:H7 str... gi\|254591151, gi... - gi\|254791751\|ref\|YP_003076588.1\| enterobactin/ferric enterobactin esterase [Escherichia coli O157:H7...	244.0	[0..1]	[374..1]
gi\|75210785, gi\|... - gi\|75210785\|ref\|ZP_00710917.1\| COG2382: Enterochelin esterase and related enzymes [Escherichia coli ...	244.0	[0..1]	[374..27]
gi\|74311119, gi\|... - gi\|74311119\|ref\|YP_309538.1\| enterobactin/ferric enterobactin esterase [Shigella sonnei Ss046], gi\|7...	244.0	[0..1]	[374..1]
gi\|193063438, gi... - gi\|75258678\|ref\|ZP_00730085.1\| COG2382: Enterochelin esterase and related enzymes [Escherichia coli ...	244.0	[0..1]	[374..27]
gi\|75236567, gi\|... - gi\|75236567\|ref\|ZP_00720655.1\| COG2382: Enterochelin esterase and related enzymes [Escherichia coli ...	244.0	[0..1]	[374..27]

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Predicted Domain #1

Region A:
Residues: [1-374]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFEVTFWWRD PQGSEEYSTI KRVWVYITGV TDHHQNSQPQ SMQRIAGTNV WQWTTQLNAN  60
   61 WRGSYCFIPT ERDDIFSVPS PDRLELREGW RKLLPQAIAD PLNLQSWKGG RGHAVSALEM 120
  121 PQAPLQPGWD CPQAPEIPAK EIIWKSERLK KSRRVWIFTT GDATAEERPL AVLLDGEFWA 180
  181 QSMPVWPVLT SLTHRQQLPP AVYVLIDAID TTHRAHELPC NADFWLAVQQ ELLPLVKAIA 240
  241 PFSDRADRTV VAGQSFGGLS ALYAGLHWPE RFGCVLSQSG SYWWPHRGGQ QEGVLLEKLK 300
  301 AGEVSAEGLR IVLEAGIREP MIMRANQALY AQLHPIKESI FWRQVDGGHD ALCWRGGLMQ 360
  361 GLIDLWQPLF HDRS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	64.154902
Match:	2b20A
Description:	Crystal Structure of Enterochelin Esterase from Shigella flexneri Enterochelin Esterase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
metal ion transmembrane transporter activity	3.03583663985352	bayes_pls_golite062009
cation transmembrane transporter activity	2.69107354583123	bayes_pls_golite062009
ion transmembrane transporter activity	2.62711952433153	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	2.36209844169981	bayes_pls_golite062009
potassium channel activity	2.33587783174115	bayes_pls_golite062009
voltage-gated cation channel activity	2.29021580025819	bayes_pls_golite062009
voltage-gated potassium channel activity	2.27946104028706	bayes_pls_golite062009
voltage-gated ion channel activity	2.17468545761843	bayes_pls_golite062009
voltage-gated channel activity	2.16264521818432	bayes_pls_golite062009
cation channel activity	2.0689599416542	bayes_pls_golite062009
inward rectifier potassium channel activity	1.87174938328996	bayes_pls_golite062009
hydrolase activity	1.56714651547107	bayes_pls_golite062009
ion channel activity	1.52503438071938	bayes_pls_golite062009
substrate-specific channel activity	1.41760137313824	bayes_pls_golite062009
channel activity	1.40804254239252	bayes_pls_golite062009
passive transmembrane transporter activity	1.40804254239252	bayes_pls_golite062009
gated channel activity	1.36997325770358	bayes_pls_golite062009
catalytic activity	1.00030903826877	bayes_pls_golite062009
transporter activity	0.91575626181147	bayes_pls_golite062009
ligand-gated channel activity	0.87402743618004	bayes_pls_golite062009
ligand-gated ion channel activity	0.87402743618004	bayes_pls_golite062009
transmembrane transporter activity	0.79859394765741	bayes_pls_golite062009
substrate-specific transporter activity	0.54937609432488	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: