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View Structure Prediction Details

Protein: C71AE_ARATH
Organism: Arabidopsis thaliana
Length: 497 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for C71AE_ARATH.

Description E-value Query
Range		 Subject
Range
F3PH_ARATH - Flavonoid 3'-monooxygenase OS=Arabidopsis thaliana GN=CYP75B1 PE=1 SV=1
 413.0 [0..1] [496..1]

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Predicted Domain #1
Region A:
Residues: [1-497] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEMIIISLCL ATILALLLLK QFLNRTYTAK VNLPPSPWRV PVIGNLHQLS LHPHRSLRSL  60
   61 SHRYGPLMLL HFGRVPVLVV SSSDVAHDLM KTHDLKVANR PQLKVVEKIF NGGREMVFSP 120
  121 YGEYWRQIKS VCIVNLLNKK KVQSFEKVRE EEISEMMERV EKASSDSSPL NLSELLLTLT 180
  181 SDVTSRVSLG RKYSKEESMS DFKIQMRKIT ELVGGFPVGE YIPCLAWIDK LRGVDEKAEE 240
  241 VSKAFGDLME KVLQEHLDAT DKPTLDFVDV LLSLERHERN GVQIRRSDIK FLILDMFLAG 300
  301 TETTYALLEW IMTELIRHPE CMKKLQDEIR AKATKLILYI SEEDVEDMKY LKAVVKEVLR 360
  361 LHPPLPLLVP RELSEDIKLK GYDIAAGTQV IINAWAIQRD TMTWGIDAEE FRPERHLDSL 420
  421 VDFRGTNFEF IPFGSGRRIC PGIGFAMALV EVTLANLVNR FNWRMEVQHS GDEYDLAEST 480
  481 GLDVCRKFPL IVFPSPA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 106.0
Match: 1pq2A
Description: Crystal Structure of Human Drug Metabolizing Cytochrome P450 2C8
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
monooxygenase activity 4.68917162030329 bayes_pls_golite062009
electron carrier activity 4.64931978461551 bayes_pls_golite062009
steroid hydroxylase activity 4.24330950518208 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 3.68151610133025 bayes_pls_golite062009
retinoic acid 4-hydroxylase activity 2.60901411823382 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 2.56821164444595 bayes_pls_golite062009
oxygen binding 2.18573646076314 bayes_pls_golite062009
oxidoreductase activity 2.00587035559143 bayes_pls_golite062009
flavonoid 3'-monooxygenase activity 1.71233606135238 bayes_pls_golite062009
vitamin D 25-hydroxylase activity 1.65825585934141 bayes_pls_golite062009
vitamin D3 25-hydroxylase activity 1.65825585934141 bayes_pls_golite062009
binding 1.64731849428898 bayes_pls_golite062009
retinoic acid binding 1.55035199545719 bayes_pls_golite062009
testosterone 6-beta-hydroxylase activity 1.4661447981611 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen 1.18865173999816 bayes_pls_golite062009
arachidonic acid monooxygenase activity 1.08222474610617 bayes_pls_golite062009
vitamin D 24-hydroxylase activity 0.843305965220103 bayes_pls_golite062009
catalytic activity 0.608111453189583 bayes_pls_golite062009
fatty acid (omega-1)-hydroxylase activity 0.44276157912762 bayes_pls_golite062009
demethylase activity 0.297054031559449 bayes_pls_golite062009
retinoid binding 0.111941744968536 bayes_pls_golite062009
isoprenoid binding 0.0595388458478079 bayes_pls_golite062009
25-hydroxycholecalciferol-24-hydroxylase activity 0.0181579856816677 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle