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View Structure Prediction Details

Protein: COPA_BACSU
Organism: Bacillus subtilis
Length: 803 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for COPA_BACSU.

Description E-value Query
Range		 Subject
Range
gi|56419437, gi|... - gi|56419437|ref|YP_146755.1| heavy metal-transporting ATPase [Geobacillus kaustophilus HTA426], gi|5...
 786.0 [0..2] [803..1]

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Predicted Domain #1
Region A:
Residues: [1-137] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLSEQKEIAM QVSGMTCAAC AARIEKGLKR MPGVTDANVN LATETSNVIY DPAETGTAAI  60
   61 QEKIEKLGYH VVTEKAEFDI EGMTCAACAN RIEKRLNKIE GVANAPVNFA LETVTVEYNP 120
  121 KEASVSDLKE AVDKLGY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 32.39794
Match: 1p6tA
Description: Structure characterization of the water soluble region of P-type ATPase CopA from Bacillus subtilis
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
copper chaperone activity 9.82063669832995 bayes_pls_golite062009
copper-dependent protein binding 9.4886676850819 bayes_pls_golite062009
metallochaperone activity 8.74818422646376 bayes_pls_golite062009
copper ion transmembrane transporter activity 8.43432598400875 bayes_pls_golite062009
copper-exporting ATPase activity 8.28760545731379 bayes_pls_golite062009
copper-transporting ATPase activity 8.16711362928142 bayes_pls_golite062009
superoxide dismutase copper chaperone activity 7.67724993505658 bayes_pls_golite062009
transition metal ion transmembrane transporter activity 7.20908701283122 bayes_pls_golite062009
copper ion binding 5.59158284280927 bayes_pls_golite062009
metal ion transmembrane transporter activity 5.4007166857771 bayes_pls_golite062009
cation transmembrane transporter activity 4.61622753861072 bayes_pls_golite062009
ion transmembrane transporter activity 4.52484959112186 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 4.12792340516867 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 4.10264569844449 bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity 3.70964017127302 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism 3.27250923701445 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions 2.98847682261773 bayes_pls_golite062009
metal ion binding 2.69806984896689 bayes_pls_golite062009
cation binding 2.69806984896689 bayes_pls_golite062009
ion binding 2.69078950610234 bayes_pls_golite062009
transition metal ion binding 2.52520930681159 bayes_pls_golite062009
binding 2.51003439707247 bayes_pls_golite062009
transporter activity 2.43435890488191 bayes_pls_golite062009
transmembrane transporter activity 2.32163502360862 bayes_pls_golite062009
substrate-specific transporter activity 2.28845421748925 bayes_pls_golite062009
mercury ion binding 1.8822811490146 bayes_pls_golite062009
primary active transmembrane transporter activity 1.62116507842838 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 1.61680623728503 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 1.59572740343301 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 1.5925429451548 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 1.59219836319916 bayes_pls_golite062009
active transmembrane transporter activity 1.53883152283038 bayes_pls_golite062009
hydrolase activity 1.26149508477113 bayes_pls_golite062009
ATPase activity 1.12732384636594 bayes_pls_golite062009
nucleoside-triphosphatase activity 1.1123150216263 bayes_pls_golite062009
pyrophosphatase activity 1.04872000948037 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 1.03270166246194 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1.02977205960797 bayes_pls_golite062009
ATPase activity, coupled 1.02520458852568 bayes_pls_golite062009
protein binding 0.989113446856899 bayes_pls_golite062009
cation-transporting ATPase activity 0.75722873989123 bayes_pls_golite062009
catalytic activity 0.270270255835869 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [138-225] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KLKLKGEQDS EAAAKKKEER KQTARLIFSA VLSFPLLWAM VSHFTFTSFI WVPDIFLNPW  60
   61 MQFALATPVQ FLIGWPFYVG AYKALRNK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [226-803] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SANMDVLVAL GTTAAYAYSL YLTFQSIGSH GHTDGLYYET SAILLTLILL GKLFETKAKG  60
   61 RSSDAIKKLM KLQAKTATVV RDGQEQIIPI DEVLVNDIVY VKPGERIPVD GEVVEGRSAV 120
  121 DESMITGESL PVDKNPGDSV TGSTVNANGF LKIKAVNVGK DTALSHIIKI VEEAQGSKAP 180
  181 IQRLADQISG IFVPIVLGIA VLTFLIWYLW AAPGDFAEAI SKFIAVLVIA CPCALGLATP 240
  241 TSIMAGSGRA AEFGILFKGG EHLEKTHRLD TIVLDKTGTV TNGKPRLTDA IPFGRFEEKD 300
  301 LLQFAAAAET GSEHPLGEAI IAGVKDKGLE IPKLTRFEAK VGAGILAEAG GKSILVGTRK 360
  361 LMESEQVEHG ALLAQMEELE AEGKTVMLVS IDGEAAGLVA VADTIKDTSR KAVARLKELG 420
  421 LDVIMMTGDN RRTAEAIAKE AGIANIIAEV LPEQKAAEIA RLQKEGRQTA MVGDGINDAP 480
  481 ALATADIGMA IGTGTDIAME TADITLIRGD LNSIADAIRM SRLTMKNIKQ NLFWALGYNS 540
  541 LGIPIAALGF LAPWIAGAAM AFSSVSVVLN ALRLQKVK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 92.39794
Match: 1mhsA
Description: Proton ATPase
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle