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View Structure Prediction Details

Protein: hst-1
Organism: Caenorhabditis elegans
Length: 715 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for hst-1.

Description E-value Query
Range
Subject
Range
gi|74181098 - gi|74181098|dbj|BAE27818.1| unnamed protein product [Mus musculus]
986.0 [0..1] [714..147]

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Predicted Domain #1
Region A:
Residues: [1-206]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAQWNRQLLD KYCKEYRVPM FSFMSSKPND QLKRIKIKGS SLWMWQNQRI QRLAVTPSII  60
   61 HRISKIGNYR QFSSSDPADW ILFETSEKFE SVLSGTVKSG YERAVVVRDK GLEDGVERII 120
  121 FGRNLTDFQV KITFLDALWW AMGNQKSFTL DRFVQVDIDD VFVGAQGTRI VEEDVRKLIS 180
  181 TQKEFRNYVQ NFTFMLGFSG SYFRNG

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [207-395]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DDLEDRGDEF LVENAEKFVW FPHMWRHNHA HEHNFTYLEA IMAQNKLFAQ NMHLPVDYPY  60
   61 AIAPQHDGVF PVHEQLFRAW RKVWNVSVTA TEEYPHFKPA TARKGFIHAG IHVLPRQTCG 120
  121 LYTHTQLFDE YPEGFDKVQK SIEGGDLFFT ILLNPISIFM THQQNYAYDR LALYTFENLF 180
  181 RFIKCWTNI

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [396-715]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KLKWQDPLTS SQLYFQKFPD ERTPLWTNPC TDPRHHAILP PSINCTKKSL PDLLIIGPQK  60
   61 TGSTALASFL SLHPNTSQNT PVPGSFEEVQ FFGGQNYLKG VEWYMSNFPS SSTVTFEKSA 120
  121 TYFDNPSAPK QAASLVPHAK IVIILQNPAQ RAYSWFQHIL AHEDPVAITA GSLEVILDSN 180
  181 STSSKKVRQR CISGGRYVHH LTKWLEHFSL QQMIFVDSDE LKMKPPTVLN SLSKWLDLPE 240
  241 FPFETYIRYS PSKGFHCRLL DGKTKCLGES KGRKYPEMPE NLRRKLDKIF SLDNSALYKF 300
  301 LRKNRLKIPT WLEESVRIRA 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 60.69897
Match: 1nstA
Description: Heparan sulfate N-deacetylase/N-sulfotransferase domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
nucleoside-triphosphatase activity 1.02433892333256 bayes_pls_golite062009
pyrophosphatase activity 0.989469851846122 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.980088098062305 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.976945962392631 bayes_pls_golite062009
binding 0.837538244475264 bayes_pls_golite062009
ATPase activity 0.508559099342241 bayes_pls_golite062009
transporter activity 0.48424022775161 bayes_pls_golite062009
transmembrane transporter activity 0.43068338046008 bayes_pls_golite062009
hydrolase activity 0.410543385742586 bayes_pls_golite062009
ATPase activity, coupled 0.366003414070823 bayes_pls_golite062009
catalytic activity 0.234613562021476 bayes_pls_golite062009
primary active transmembrane transporter activity 0.229052859670546 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 0.221848871525989 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 0.190228662787185 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 0.186067331649217 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 0.185248585258315 bayes_pls_golite062009
active transmembrane transporter activity 0.0712149467387941 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle