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View Structure Prediction Details

Protein: tbx-7
Organism: Caenorhabditis elegans
Length: 327 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for tbx-7.

Description E-value Query
Range
Subject
Range
gi|109114680 - gi|109114680|ref|XP_001106915.1| PREDICTED: similar to T-box 2 [Macaca mulatta]
331.0 [0..16] [319..305]

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Predicted Domain #1
Region A:
Residues: [1-250]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEGYGRSLF SEKHFPHDRQ LLPPFTTTMS LGSFFSFPAS SAFFDRKKDD GVIDNPNVEL  60
   61 VNRNLWSTFL ECGTEMIITK KGRRMFPLVK LKLSGLDKNS NYTIIMEMIS VDKLRYKFWN 120
  121 GNWIVAGVGE HHPLPTCFVH PQSPRSGEWW MTDGVDFKMA KLSNNPFNND GHIVLNSMHR 180
  181 YNPRFHIVRA DSSGQPILAS LKTFSFKETE FIAVTAYQND VVTKCKIDNN PFAKGFRNID 240
  241 TVRKRKMNQI 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 80.69897
Match: 1h6fA
Description: T-box protein 3, tbx3
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 3.82913410895101 bayes_pls_golite062009
DNA binding 3.66817147088612 bayes_pls_golite062009
transcription regulator activity 3.64801189357929 bayes_pls_golite062009
nucleic acid binding 3.4281783503437 bayes_pls_golite062009
transcription factor activity 3.00834358271623 bayes_pls_golite062009
sequence-specific DNA binding 2.78676291654359 bayes_pls_golite062009
protein binding 2.61625563263605 bayes_pls_golite062009
transcription activator activity 2.550621891551 bayes_pls_golite062009
DNA strand annealing activity 1.17814334604363 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.03496325074066 bayes_pls_golite062009
double-stranded DNA binding 0.90477390899557 bayes_pls_golite062009
structure-specific DNA binding 0.67715424282347 bayes_pls_golite062009
chromatin binding 0.34201146905158 bayes_pls_golite062009
transcription repressor activity 0.21694638611622 bayes_pls_golite062009
protein dimerization activity 0.0889583851427092 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [251-327]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ISTPPASEDE EPEVKRTKSE IEAVMFSDPK VPQMSLQLIS QWQEALLSTI VQIPITNQKS  60
   61 SSERKSGFGV VDLLGSS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle