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View Structure Prediction Details

Protein: drp-1
Organism: Caenorhabditis elegans
Length: 712 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for drp-1.

Description E-value Query
Range
Subject
Range
gi|28422236, gi|... - gi|28422236|gb|AAH44291.1| MGC53884 protein [Xenopus laevis], gi|148236079|ref|NP_001079557.1| simil...
659.0 [0..1] [712..1]

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Predicted Domain #1
Region A:
Residues: [1-339]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MENLIPVVNK LQDVFATLGR KEDQIQLPQI VVVGSQSAGK SSVLENLVGR DFLPRGTGIV  60
   61 TRRPLILQLN HVALDDESKR RRSNGTLLTD DWAMFEHTGS KVFTDFDAVR KEIEDETDRV 120
  121 TGVNKGISLL PISLKIYSHR VVSLSLVDLP GITKIPVGDQ PVNIEEQIRE MILLYISNPS 180
  181 SIILAVTPAN QDFATSEPIK LAREVDAGGQ RTLAVLTKLD LMDQGTDAMD VLMGKVIPVK 240
  241 LGIIGVVNRS QQNILDNKLI VDAVKDEQSF MQKKYPTLAS RNGTPYLAKR LNMLLMHHIR 300
  301 NCLPALKARV SIMNAQCQSD LVAFGEPVED KNRTLLQII

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 102.0
Match: 2akaB
Description: Structure of the nucleotide-free myosin II motor domain from Dictyostelium discoideum fused to the GTPase domain of dynamin 1 from Rattus norvegicus
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transporter activity 3.10463051760206 bayes_pls_golite062009
transmembrane transporter activity 2.95886887664984 bayes_pls_golite062009
nucleoside-triphosphatase activity 2.74389108884083 bayes_pls_golite062009
pyrophosphatase activity 2.67097555143215 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 2.65161658635465 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 2.64849912301318 bayes_pls_golite062009
active transmembrane transporter activity 2.50494515048649 bayes_pls_golite062009
primary active transmembrane transporter activity 2.39629638016861 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 2.39600931083427 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 2.36051733655256 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 2.35906629925754 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 2.35679406876731 bayes_pls_golite062009
ATPase activity 2.2625504298178 bayes_pls_golite062009
ATPase activity, coupled 2.24901251684901 bayes_pls_golite062009
binding 2.01755875920323 bayes_pls_golite062009
substrate-specific transporter activity 1.65609907941094 bayes_pls_golite062009
motor activity 1.47133910026814 bayes_pls_golite062009
protein transporter activity 1.37245678118001 bayes_pls_golite062009
hydrolase activity 1.34710139310747 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 1.3182108176243 bayes_pls_golite062009
purine nucleotide binding 0.929901285538132 bayes_pls_golite062009
nucleotide binding 0.922442819194247 bayes_pls_golite062009
purine ribonucleotide binding 0.920987930180051 bayes_pls_golite062009
ribonucleotide binding 0.920926158369519 bayes_pls_golite062009
microfilament motor activity 0.723407201613229 bayes_pls_golite062009
ion transmembrane transporter activity 0.704934361725919 bayes_pls_golite062009
cytoskeletal protein binding 0.568484017802328 bayes_pls_golite062009
actin binding 0.563996324417607 bayes_pls_golite062009
protein transmembrane transporter activity 0.46552249844591 bayes_pls_golite062009
GTPase activity 0.437665353870877 bayes_pls_golite062009
ATP binding 0.41092997612902 bayes_pls_golite062009
adenyl ribonucleotide binding 0.385813421701492 bayes_pls_golite062009
adenyl nucleotide binding 0.377870145186619 bayes_pls_golite062009
signal recognition particle binding 0.29390189699022 bayes_pls_golite062009
cation transmembrane transporter activity 0.282397764628576 bayes_pls_golite062009
DNA strand annealing activity 0.0887104483353087 bayes_pls_golite062009
protein binding 0.071010918255742 bayes_pls_golite062009
nucleic acid binding 0.0636334376764289 bayes_pls_golite062009
signal transducer activity 0.0529006651532686 bayes_pls_golite062009
molecular transducer activity 0.0529006651532686 bayes_pls_golite062009
macromolecule transmembrane transporter activity 0.00571427458217011 bayes_pls_golite062009
P-P-bond-hydrolysis-driven protein transmembrane transporter activity 0.00571427458217011 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [340-545]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TRFATAYTST IEGTARNIET TELCGGARIC YIFHDTFGRS LESVNPLENL TQLDILTAIR  60
   61 NATGPRPALF VPEVSFELLV KRQIQRLEEP SLRCVELVHE EMQRMVQHCG FTTQQEMIRF 120
  121 PRLYDKINEV VSGVLKERLK PTNELVENLV AIELAYINTK HPEFTEANLV TLLKEELLLD 180
  181 DRHGRSRNRH ASTGERAVSA HGEQQL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [546-597]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QPVPGVNGVD LNAVLQQQQQ QSQNQRASNG FLGLFGNAAA SSKTSPQEKQ SA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [598-712]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NFLPEVPETQ LGRKLTSREQ RDVAIIERLI RNYFIIVRKN IQDSVPKAIM ALLVNFVRDN  60
   61 LQSELVRQLY KPDEMDDLLA ETEDMAQRRR DTLETMKALQ QASVIISEVR ETQVW

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 28.161151
Match: PF02212.9
Description: No description for PF02212.9 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle